The Pharmacogenetics of Morphine-Induced Analgesia: A Case Report

Journal of Pain and Symptom Management

Volumn 36, Issue 1, 2008, Pages

  Bianchi, Mauro ^a   Fornasari, Diego ^a   Antonini, Ruth Adele ^a   Beretta Piccoli, Benedetta Terziroli ^b   Nava, Sistiana ^b   Neuenschwander, Hans ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b Hospice Ticino   (Switzerland)

^c ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE;

ADULT; ALLELE; ANALGESIA; ANAMNESIS; BONE METASTASIS; CANCER PAIN; CASE REPORT; DRUG DOSE ESCALATION; FEMALE; HUMAN; LETTER; LUNG CARCINOMA; PHARMACOGENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; VISUAL ANALOG SCALE;

ANALGESICS, OPIOID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENETIC SCREENING; HUMANS; MIDDLE AGED; MORPHINE; PAIN; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 45849116286     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2008.02.002     Document Type: Letter

References (16)

1. Expert Working Group of the Research Network of the European Association for the Palliative Care. Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br J Cancer 84 (2001) 587-593
2. Riley J., Ross J.R., Rutter D., et al. No pain relief from morphine? Individual variation in sensitivity to morphine and the need to switch to an alternative opioid in cancer patients. Support Care Cancer 14 (2006) 56-64
3. Stamer U.M., and Stüber F. The pharmacogenetics of analgesia. Expert Opin Pharmacother 8 (2007) 2235-2245
4. Befort K., Filliol D., Decaillot F.M., et al. A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signalling. J Biol Chem 276 (2001) 3130-3137
5. de Wildt S.N., Kearns G.L., Leeder J.S., and van der Anker J.N. Glucuronidation in humans: pharmacogenetic and developmental aspects. Clin Pharmacokinet 36 (1999) 439-452
6. Holthe M., Rakvag T.N., Klepstad P., et al. Sequence variation in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. Pharmacogenomics J 3 (2003) 17-26
7. Thompson S.J., Koszdin K., and Bernards C.M. Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein. Anesthesiology 92 (2000) 1392-1399
8. Brinkmann U., Roots I., and Eichelmann M. Pharmacogenetics of the human drug-transporter gene MDR-1: impact of polymorphisms on pharmacotherapy. Drug Discov Today 6 (2001) 835-839
9. Mercadante S., Fulfaro F., Casaccio A., and Barresi L. Investigation of an opioid response categorization in advanced cancer patients. J Pain Symptom Manage 18 (1999) 347-352
10. Reyes-Gibby C.C., Shete S., Rakvag T., et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 130 (2007) 25-30
11. Hirota T., Ieiri I., Tarane H., et al. Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy. Drug Metab Dispos 31 (2003) 677-680
12. Duguay Y., Baar C., Skorpen F., and Guillemette C. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 75 (2004) 223-233
13. Wang D., Johnson A.D., Papp A.C., et al. Mulitdrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics 15 (2005) 693-704
14. Breda M., Bianchi M., Ripamonti C., et al. Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration. Int J Clin Pharm Res 12 (1991) 93-97
15. Gourlay G.K. Advances in opioid pharmacology. Support Care Cancer 13 (2005) 153-159
16. Lötsch J., Skarke C., Liefhold J., and Geisslinger G. Genetic predictors of the clinical response to opioid analgesics. Clinical utility and future perspectives. Clin Pharmacokinet 43 (2004) 983-1013