Mutation of a putative amphipathic α-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signalling

Molecular Pharmacology

Volumn 53, Issue 3, 1998, Pages 451-458

  Carlson, Steve A ^a   Chatterjee, Tapan K ^a   Murphy, Kenneth P ^a   Fisher, Rory A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APAFANT; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE; CELL STRAIN BHK; MUTATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0031956894     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.3.451     Document Type: Article

References (40)

1. Amatruda TT, Gerard NP, Gerard C, and Simon MI (1993) Specific interactions of chemoattractant factor receptors with G proteins. J Biol Chem 268:10139-10144.
2. Bastien Y and Mazer BD (1994) Detection of the human platelet-activating factor receptor mRNA in human B lymphocytes by polymerase chain reaction on reverse transcripts (RT-PCR). Biochem Biophys Res Commun 202:1373-1379.
3. Battye KM, Parkinson TJ, Jenner LJ, Evans G, O'Neill C, and Lamming GE (1993) Potential synergism between platelet-activating factor and ALPHA-1-recombinant interferon in promoting luteal maintenance in cycling ewes. J Reprod Fertil 97:21-26.
4. Behrens TW and Goodwin JS (1990) Control of human T cell proliferation by platelet-activating factor, Int J Immunopharmacol 12:175-184.
5. Bito H, Honda Z, Nakamura M, and Shimizu T (1994) Cloning, expression and tissue distribution of rat platelet-activating factor receptor cDNA. Eur J Biochem 221: 211-218.
6. q/11 by the M3 muscarinic acetylcholine receptor. J Biol Chem 270:17741-17748.
7. Bluml K, Mutschler E, and Wess J (1994) Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein-coupling. Proc Natl Acad Sci USA 91:7980-7984.
8. Braquet P, Touqui L, Shen TY, and Vargaftig BB (1987) Perspectives in platelet-activating factor research. Pharmacol Rev 39:97-145.
9. Carlson SA, Chatterjee TK, and Fisher RA (1996a) The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins: studies using intracellular domain minigenes and receptor chimeras. J Biol Chem 271:23146-23153.
10. Carlson SA, Chatterjee TK, and Fisher RA (1996b) Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. Recept Signal Transd 6:111-120.
11. Cotecchia S, Exum S, Caron MG, and Lefkowitz RJ (1990) Regions of the alpha-1 adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity to biological function. Proc Natl Acad Sci USA 87:2896-2900.
12. 15N assignments and secondary structure. Biochemistry 32:6032-6040.
13. Hattori M, Adachi H, Tsujimoto M, Arai H, and Inoue K (1994) Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor (acetylhydrolase). Nature (Lond) 370:216-218.
14. Henderson HE, Ma Y, Liu MS, Clarke-Lewis I, Maeder DL, Kastelein JJ, Brunzell JD, and Hayden MR (1993) Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region. J Lipid Res 34:1593-1602.
15. Honda Z, Nakamura M, Miki I, Minami M, Watanabe T, Seyama Y, Okado H, Toh H, Ito K, Miyamoto T, and Shimizu T (1991) Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature (Lond) 349:342-346.
16. Honda Z, Takano T, Gotoh Y, Nishida E, Ito K, and Shimizu T (1994) Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J Biol Chem 269: 2307-2315.
17. Hwang S-B, Lam M-H, and Pong S-S (1986) Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. J Biol Chem 261:532-537.
18. Ishii S, Nagase T, Tashiro F, Ikuta K, Sato S, Waga I, Kume K, Miyazaki J, and Shimizu T (1997) Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J 16:133-142.
19. Jones MK, Anantharamaiah GM, and Segrest JP (1992) Computer programs to identify and classify amphipathic alpha helical domains. J Lipid Res 33:287-296.
20. Kato K, Clark GD, Bazan NG, and Zorumski CF (1994) Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation. Nature (Lond) 367:175-179.
21. Kim FJ, Moore EE, Moore FA, Biffl WL, Fontes B, and Banerjee A (1995) Reperfused gut elaborates PAF that chemoattracts and prime neutrophils. J Surg Res 58:636-640.
22. Lee S, Aoki R, Oishi O, Aoyagi H, and Yamasaki N (1992) Effect of amphipathic peptides with different alpha-helical contents on liposome function. Biochim Biophys Acta 1103:157-162.
23. Li SC, Goto NK, Williams KA, and Deber CM (1996) Alpha-helical, but not beta-sheet, propensity of proline is determined by peptide environment. Proc Natl Acad Sci USA 93:6676-6681.
24. Liu J, Conklin BR, Blin N, Yun J, and Wess J (1995) Identification of a receptor/G protein contact site critical for signaling specificity and G protein activation. Proc Natl Acad Sci USA 92:11642-11646.
25. Liu J and Wess J (1996) Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family. J Biol Chem 271:8772-8778.
26. Miwa M, Miyaka T, Yananaka T, Sugatani J, Suzuki Y, Sakata S, Araki Y, and Matsumoto M (1988) Characterization of platelet-activating factor (PAF) acetylhydrolase: correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J Clin Invest 82:1983-1991.
27. Murayama T and Ui M (1985) Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. J Biol Chem 260:7226-7233.
28. Nakamura M, Honda Z, Izumi T, Sakanaka, C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M, and Shimizu T (1991) Molecular cloning and expression of platelet-activating factor from human leukocytes. J Biol Chem 266:20400-20405.
29. Namba T, Sugimoto Y, Negishi M, Irie A, Ushikubi F, Kakizuka A, Ito S, Ichikawa A, and Narumiya S (1993) Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature (Lond) 365:166-170.
30. Nourshargh S, Larkin SW, Das A, and Williams, TJ (1995) Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor. Blood 85:2553-2558.
31. Nussenzveig DR, Thaw C, and Gershengorn MC (1994) Inhibition of inositol second messenger formation by intracellular loop one of a human calcitonin receptor. J Biol Chem 269:28123-28129.
32. Parent J-L, Le Gouille C, de Brum-Fernandes AJ, Rola-Pleszzczynski M, and Stankova J (1996) Mutations of two adjacent amino acids generate inactive and constitutively activated forms of the human platelet-activating factor receptor. J Biol Chem 271:7949-7955.
33. Resnick MB, Colgan SP, Pafkos CA, Delp-Archer C, McGuirk D, Weller PF, and Madara JL (1995) Human eosinophils migrate across an intestinal epithelium in response to platelet-activating factor. Gastroenterology 108:409-416.
34. Samama P, Cotecchia S, Costa T, and Lefkowitz RJ (1993) A mutation-induced activated state of the beta 2-adrenergic receptor: extending the ternary complex model. J Biol Chem 268:4625-4636.
35. Sauer UH, San DP, and Matthews BW (1992) Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J Biol Chem 267:2393-2399.
36. Strader CD, Dixon RA, Cheung AH, Candelore MR, Blake AD, and Sigal IS (1987) Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity. J Biol Chem 262:16439-16443.
37. Sukumar M and Higashijima T (1992) G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide. J Biol Chem 267:21421-21424.
38. Takano T, Honda Z, Sakanaka C, Izumi T, Kameyama K, Haga K, Haga T, Kurokaws K, and Shimizu T (1994) Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. J Biol Chem 269: 22453-2245.
39. Voss T, Wallner E, Czernilofsky AP, and Freissmuth M (1993) Amphipathic alpha-helical structure does not predict the ability of receptor-derived synthetic peptides to interact with guanine nucleotide-binding regulatory proteins. J Biol Chem 268:4637-4642.
40. Wang H, Jaquette J, Collison K, and Segaloff DL (1993) Positive charges in a putative amphiphilic helix in the carboxyl-terminal region of the third intracellular loop of the leuteinizing hormone/chorionic gonadotropin receptor are not required for hormone-stimulated cAMP production but are necessary for expression of the receptor at the plasma membrane. Mol Endocrinol 7:1437-1444.