Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury

Brain Injury

Volumn 22, Issue 7-8, 2008, Pages 611-615

  Weiner, Myron F ^a,b   Vega, Gloria L ^a   Diaz Arrastia, Ramon ^b   Moore, Carol ^b   Madden, Christopher ^b   Hudak, Anne ^b   Lutjohann, Dieter ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

24 S hydroxycholesterol; Closed head injury; Oxysterols

Indexed keywords

24 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL DERIVATIVE; LATHOSTEROL; OXYSTEROL; PROPOFOL;

ADOLESCENT; ADULT; AGE; ANASTOMOSIS; ANESTHESIA INDUCTION; ARTICLE; AXONAL INJURY; BLOOD ANALYSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CRANIOTOMY; FEMALE; GLASGOW COMA SCALE; HEAD INJURY; HOSPITAL ADMISSION; HUMAN; INJURY SEVERITY; INTENSIVE CARE UNIT; INTRACRANIAL HYPERTENSION; MALE; RATING SCALE; RESPIRATORY TRACT INTUBATION;

EID: 45849100113     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.1080/02699050802196037     Document Type: Article

References (24)

1. Franz, G., Beer, R., Kampfl, A., Engelhardt, K., Schmutzhard, E., Ulmer, H. and Deisenhammer, F. (2003) Amyloid beta 1-42 and tau in cerebrospinal fluid after severe traumatic brain injury. Neurology, 60, pp. 1457-1461.
2. Zemlan, FP, Rosenberg, WS, Puebbe, PA, Campbell, TA, Dean, GE, Weiner, NE, Cohen, JA, Rudick, RA and Woo, D. (1999) Quarification of axonal damage in traumatic brain injury: Affinity purification and characterization of cerebrospinal fluid tau proteins. Journal of Neurochemistry, 72, pp. 741-750.
3. Zemlan, FP, Jauch, EC, Muchahey, JJ, Gabbita, SP, Rosenberg, WS, Speciale, SG and Zuccarello, M. (2002) C-tau biomarker of neuronal damage in severe brain injured patients; association with elevated intracranil pressure and clinical outcome. Brain Research, 947, pp. 131-139.
4. Gabbita, SP, Scheff, SW, Menard, RM, Roberts, K., Fugaccia, I. and Zemlan, FP (2005) Cleaved-tau: A biomarker of neuronal damage after traumatic brain injury. Journal of Neurotrauma, 22, pp. 83-94.
5. Ringger, NC, O'Steen, BE, Brabjam, JG, Silver, X., Pineda, J., Wang, KK, Hayes, RL and Papa, L. (2004) A novel marker for traumatic brain injury: CSF alpha II-spectrin breakdown product levels. Journal of Neurotrauma, 21, pp. 1443-1456.
6. Kleindienst, A., Hesse, F., Bullock, MR and Buchfelder, M. (2007) The neurotrophic protein S100B: Value as a marker of brain damage and possible therapeutic implications. Progress in Brain Research, 161, pp. 317-325.
7. Hardemark, HG, Ericcson, N., Kotwica, Z., Rundstrom, G., Mendel-Hartvig, I., Olsson, Y., Pahlman, S. and Persson, L. (1989) S-100 protein and neuron-specific enolase in CSF after experimental trauma or focal ischemic brain damage. Journal of Neurosurgery, 71, pp. 727-731.
8. Berger, RP, Adelson, PD, Pierce, MC, Dulani, T., Cassidy, LD and Kochanek, PM (2005) Serum neuron-specific enolase, S10-0B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. Journal of Neurosurgery, 103, pp. 61-68.
9. Weiss, N., Sanchez-Pena, P., Roche, S., Beaudeux, JL, Colonne, C., Coriat, P. and Puybasset, L. (2006) Prognosis value of plasma S100B protein levels after subarachnoid anueurysmal hemorrhage. Anesthesiology, 104, pp. 658-666.
10. Dietschy, JM and Turley, SD (2004) Cholesterol metabolism in the central nervous system during early development and in the mature animal. Journal of Lipid Research, 45, pp. 1375-1397.
11. Bjorkhem, I. and Meaney, S. (2004) Brain cholesterol: Long secret life behind a barrier. Arterosclerosis, Thrombosis and Vascular Biology, 24, pp. 806-815.
12. Bjorkhem, I., Lutjohann, D., Diczfalusy, U., Stahle, L., Ahlborg, G. and Wahren, J. (1998) Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in circulation. Journal of Lipid Research, 39, pp. 1594-1600.
13. Lund, EG, Guileyardo, JM and Russell, DW (1999) CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proceedings of the National Academy of Sciences (USA), 96, pp. 7238-7243.
14. Lutjohann, D., Breuer, G. and Ahlborg, I. (1996) Siden Å, Diczfalusy U, Bjorkem I. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proceedings of the National Academy of Sciences (USA), 93, pp. 9799-9804.
15. Bretillon, L., Lutjohann, D., Ståhle, L., Widhe, T., Bindl, L., Eggertsen, G., Diczfalusy, U. and Bjorkhem, I. (2000) Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. Journal of Lipid Research, 41, pp. 840-845.
16. Teasdale, G. and Jennett, B. (1974) Assessment of coma and impaired consciousness. A practical scale. Lancet, 2, pp. 81-84.
17. Osler, T., Baker, SP and Long, W. (1997) A modification of the Injury Severity Score that both improves accuracy and simplifies scoring. Journal of Trauma, 43, pp. 922-925.
18. Vega, GL, Weiner, MF, Lipton, AM, von Bergmann, K., Lutjohann, D., Moore, C. and Svetlik, D. (2003) Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Archives of Neurology, 60, pp. 510-515.
19. Lutjohann, D., Bjorkem, I., Beil, UF and von Bergmann, K. (1995) Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: Effect of sitostanol treatment. Journal of Lipid Research, 36, pp. 1763-1773.
20. Lutjohann, D., Papassotiropoulos, A., Bjorkem, I., Locatelli, S., Bagli, M., Oehring, RD, Schlegel, U., Jessen, F., Rao, ML, von Bergmann, K. and Heun, R. (2000) Plasma 24S-hydroxycholesterol (cerebrosterol) in increased in Alzheimer and vascular demented patients. Journal of Lipid Research, 41, pp. 195-198.
21. Vega, GL, Weiner, MF, Kolsch, H., von Bergmann, K., Heun, R., Lutjohann, D., Nguyen, A. and Moore, C. (2004) The effects of gender and CYP 246 and apoE polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. Current Alzheimers Research, 1, pp. 71-77.
22. Holdenreider, S., Lutjohann, D., Geiger, S., von Bergmann, K., Stieber, P. and Hamman, GF (2004) Does brain-specific 24S-hydroxycholesterol in plasma indicate disruption of the blood-brain barrier in patients with ischemeic stroke?. Neuroscience Letters, 368, pp. 201-204.
23. Dunham, CM, Fealk, MH and Sever 3rd, WE (2003) Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Critical Care, 7, pp. 413-414.
24. Bakalar, B., Hyspler, R., Pachl, J. and Zadak, Z. (2003) Changes in cholesterol and its precursors during the first days after major trauma. Wiener Klinische Wochenschrift, 115, p. 9.