Molecular basis of G6PD deficiency: Current status and its perspective

Acta Medica Iranica

Volumn 46, Issue 3, 2008, Pages 167-182

  Noori Daloii, Mohammad Reza ^a   Daneshpajooh, M ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Favism; Glucose 6 phosphate dehydrogenase; Hemolysis; Senescence

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PRIMAQUINE;

AGING; CELL GROWTH; CLINICAL FEATURE; CPG ISLAND; ENZYME DEFICIENCY; EXON; FAVISM; GENE MUTATION; GENETIC POLYMORPHISM; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HEMOLYTIC ANEMIA; HETEROZYGOTE DETECTION; HUMAN; HYPERBILIRUBINEMIA; IRAN; LONGEVITY; MALARIA; NEOPLASM; NONHUMAN; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; REVIEW; SENESCENCE; VIRUS INFECTION; X CHROMOSOME;

EID: 45849095191     PISSN: 00446025     EISSN: 00446025     Source Type: Journal    
DOI: None     Document Type: Review

References (119)

1. Beutler E. The hemolytic effect of primaquine and related compounds: a review. Blood. 1959 Feb; 14(2):103-139.
2. Pauling L, Itano HA, Singer SJ, et al. Sickle cell anemia a molecular disease. Science. 1949 Nov 25;110(2865):543-548.
3. Luzzatto L. Glucose 6-phosphate dehydrogenase deficiency: from genotype to phenotype. Haematologica. 2006 Oct; 91(10):1303-1306.
4. Noori-Daloii MR, Hajebrahimi Z, Najafi L, Mesbah-Namin SA, Mowjoodi A, Mohammad Ganji S, Yekaninejad MS, Sanati MH. A comprehensive study on the major mutations in glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in the coastal provinces of Caspian Sea in the north of Iran. Clin Biochem. 2007 Jun; 40(9-10):699-704.
5. Mesbah Namin S.A, Sanati M.H, Noori Daloii M.R. Spread of the glucose-6-phosphate dehydrogenase variant (G6PD Mediterranean) in one of the coastal provinces of Caspian sea in Iran. J. Sci. I. R. Iran. 2000; 11(4)
6. Mesbah-Namin SA, Sanati MH, Mowjoodi A, Mason PJ, Vulliamy TJ, Noori-Daloii MR. Three major glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in Mazandaran state of Iran. Br J Haematol. 2002 Jun; 117(3):763-764.
7. Noori-Daloii MR, Hajebrahimi Z, Najafi L, et al. Molecular identification of the most prevalent mutation of glucose-6-phosphate dehydrogenase (G6PD) gene in deficient patients in Gilan province. J. Sci. I. R. Iran. 2003; 14(4), 327-331
8. Noori-Daloii MR, Najafi L, Mohammad Ganji S, Hajebrahimi Z, Sanati MH. Molecular identification of mutations in G6PD gene in patients with favism in Iran. J Physiol Biochem. 2004 Dec; 60(4):273-277.
9. Noori-Daloii MR, Yousefi A, Ganji SM, et al. Molecular identification of the most prevalent mutation of glucose-6-phosphate dehydrogenase gene in deficient patients in Sistan and Balochestan province of Iran. J. Sci. I. R. Iran. 2005; 16(4), 321-325
10. Noori-Daloii MR., Soltanian S, Ganji SM, et al. Molecular identification of the most prevalent mutation of glucose-6-phosphate dehydrogenase gene in deficient patients in Sistan and Balochestan province of Iran. J. Sci. I. R. Iran. 2006; 17(2); 103-106.
11. Noori-Daloii MR, Hejazi SH, Yousefi A, et al. Identification of mutations in G6PD gene in patients in Hormozgan province of Iran. J. Sci. I. R. Iran. 2006; 17(4), 313-316
12. Karimi M, Martinez di Montemuros F, Danielli MG, Farjadian S, Afrasiabi A, Fiorelli G, Cappellini MD. Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Fars province of Iran. Haematologica. 2003 Mar; 88(3):346-347.
13. Rahimi Z, Vaisi-Raygani A, Nagel RL, Muniz A. Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Kurdish population of Western Iran. Blood Cells Mol Dis. 2006 Sep-Oct; 37(2):91-94.
14. Gibbs WN, Gray R, Lowry M. Glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Jamaica. Br J Haematol. 1979 Oct; 43(2):263-274.
15. Niazi GA, Adeyokunnu A, Westwood B, Beutler E. Neonatal jaundice in Saudi newborns with G6PD Aures. Ann Trop Paediatr. 1996 Mar; 16(1):33-37.
16. Kaplan M, Hammerman C, Vreman HJ, Stevenson DK, Beutler E. Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes. J Pediatr. 2001 Jul; 139(1):137-140.
17. Corchia C, Balata A, Meloni GF, Meloni T. Favism in a female newborn infant whose mother ingested fava beans before delivery. J Pediatr. 1995 Nov; 127(5):807-808.
18. Bizzarro MJ, Colson E, Ehrenkranz RA. Differential diagnosis and management of anemia in the newborn. Pediatr Clin North Am. 2004 Aug; 51(4):1087-1107.
19. Kaplan M, Vreman HJ, Hammerman C, Leiter C, Abramov A, Stevenson DK. Contribution of haemolysis to jaundice in Sephardic Jewish glucose-6-phosphate dehydrogenase deficient neonates. Br J Haematol. 1996 Jun; 93(4):822-827.
20. Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin North Am. 2004 Aug; 51(4):843-861.
21. Salati LM, Amir-Ahmady B. Dietary regulation of expression of glucose-6-phosphate dehydrogenase. Annu Rev Nutr. 2001;21:121-140.
22. Sharma SC, Sharma S, Gulati OP. Pycnogenol prevents haemolytic injury in G6PD deficient human erythrocytes. Phytother Res. 2003 Jun; 17(6):671-674.
23. Mehta A, Mason PJ, Vulliamy TJ. Glucose-6-phosphate dehydrogenase deficiency. Baillieres Best Pract Res Clin Haematol. 2000 Mar; 13(1):21-38.
24. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704-712.
25. th ed. Philadelphia: Churchill Livingstone, 2000; 57-60.
26. Yoshida A. Glucose 6-phosphate dehydrogenase of human erythrocytes. I. Purification and characterization of normal (B+) enzyme. J Biol Chem. 1966 Nov 10; 241(21):4966-4976.
27. Jalloh A, Tantular IS, Pusarawati S, Kawilarang AP, Kerong H, Lin K, Ferreira MU, Matsuoka H, Arai M, Kita K, Kawamoto F. Rapid epidemiologic assessment of glucose-6-phosphate dehydrogenase deficiency in malaria-endemic areas in Southeast Asia using a novel diagnostic kit. Trop Med Int Health. 2004 May; 9(5):615-623.
28. Oblender M. Index of suspicion. Case 3. Kernicterus in a baby girl homozygous for glucose-6-phosphate dehydrogenase deficiency. Pediatr Rev. 1993 May; 14(5):191, 193.
29. Beutler E: The red cell: A tiny dynamo, in Wintrobe MM (ed): Blood Pure and Eloquent, New York, NY, McGraw-Hill.l980; p 141
30. Dern RJ, Beutler E, Alving AS. The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character. J Lab Clin Med. 1954 Aug; 44(2):171-176.
31. Iwai K, Matsuoka H, Kawamoto F, et al. A rapid single-step screening method for glucose-6-phosphate dehydrogenase deficiency in field applications. Japanese Journal of Tropical Medicine and Hygiene. 2003;31, 93-97.
32. American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep; 108(3):776-789.
33. Heintz B, Bock TA, Kierdorf H, Maurin N. Haemolytic crisis after acetaminophen in glucose-(6)-phosphate dehydrogenase deficiency. Klin Wochenschr. 1989 Oct 17;67(20):1068.
34. Szeinberg A, Sheba C, Hirshorn N, et al. Studies on erythrocytes in cases with past history of favism and drug-induced acute hemolytic anemia. Blood. 1957; 12, 603.
35. Meloni T, Forteleoni G, Ena F, Meloni GF. Glucose-6-phosphate dehydrogenase deficiency and bacterial infections in northern Sardinia. J Pediatr. 1991 Jun; 118(6):909-911.
36. Ronquist G, Theodorsson E. Inherited, nonspherocytic haemolysis due to deficiency of glucose-6-phosphate dehydrogenase. Scand J Clin Lab Invest. 2007;67(1):105-111.
37. Yoshida A. Hemolytic anemia and G6PD deficiency. Science. 1973 Feb 9;179(73):532-537.
38. Rattazzi MC, Corash LM, van Zanen GE, Jaffé ER, Piomelli S. G6PD deficiency and chronic hemolysis: four new mutants - relationships between clinical syndrome and enzyme kinetics. Blood. 1971 Aug; 38(2):205-218.
39. De Flora A, Morelli A, Giuliano F. Human erythrocyte glucose 6-phosphate dehydrogenase. Content of bound coenzyme. Biochem Biophys Res Commun. 1974 Jul 10;59(1):406-413.
40. Morelli A, Benatti U, Giuliano F, De Flora A. Human erythrocyte glucose 6-phosphate dehydrogenase. Evidence for competitive binding of NADP and NADPH. Biochem Biophys Res Commun. 1976 May 17;70(2):600-606.
41. Kirkman HN, Hendrickson EM. Glucose 6-phosphate dehydrogenase from human erythrocytes. II. Subactive states of the enzyme from normal persons. J Biol Chem. 1962 Jul; 237:2371-2376
42. Canepa L, Ferraris AM, Miglino M, Gaetani GF. Bound and unbound pyridine dinucleotides in normal and glucose-6-phosphate dehydrogenase-deficient erythrocytes. Biochim Biophys Acta. 1991 May 24;1074(1):101-104.
43. Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN. Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan; 73(1):334-339.
44. Pandolfi PP, Sonati F, Rivi R, Mason P, Grosveld F, Luzzatto L. T Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995 Nov 1;14(21):5209-5215.
45. Mason PJ. New insights into G6PD deficiency. Br J Haematol. 1996 Sep; 94(4):585-591.
46. Ruwende C, Hill A. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med. 1998 Jul; 76(8):581-588.
47. Persico MG, Viglietto G, Martini G, Toniolo D, Paonessa G, Moscatelli C, Dono R, Vulliamy T, Luzzatto L, D'Urso M. Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5′ non-coding region. Nucleic Acids Res. 1986 Mar 25;14(6):2511-2522.
48. Persico MG, Viglietto G, Martini G, et al. Analysis of the primary structure of human G 6 PD deduced from the cDNA sequence, in Yoshida A, Beutler E (eds): Glucose-6-Phosphate Dehydrogenase, Orlando, FL, Academic.1986; p 503.
49. Toniolo D, Persico MG, Battistuzzi G, Luzzatto L. Partial purification and characterization of the messenger RNA for human glucose-6-phosphate dehydrogenase. Mol Biol Med. 1984 Apr; 2(2):89-103.
50. Takizawa T, Huang IY, Ikuta T, Yoshida A. Human glucose-6-phosphate dehydrogenase: primary structure and cDNA cloning. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4157-4161.
51. Martini G, Toniolo D, Vulliamy T, Luzzatto L, Dono R, Viglietto G, Paonessa G, D'Urso M, Persico MG. Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase. EMBO J. 1986 Aug;5(8):1849-55.
52. Toniolo D, Filippi M, Dono R, Lettieri T, Martini G. The CpG island in the 5' region of the G6PD gene of man and mouse. Gene. 1991 Jun 30;102(2):197-203.
53. Philippe M, Larondelle Y, Lemaigre F, Mariamé B, Delhez H, Mason P, Luzzatto L, Rousseau GG. Promoter function of the human glucose-6-phosphate dehydrogenase gene depends on two GC boxes that are cell specifically controlled. Eur J Biochem. 1994 Dec 1;226(2):377-384.
54. Rank KB, Harris PK, Ginsberg LC, Stapleton SR. Isolation and sequence of a rat glucose-6-phosphate dehydrogenase promoter. Biochim Biophys Acta. 1994 Jan 18;1217(1):90-92.
55. Hodge DL, Charron T, Stabile LP, Klautky SA, Salati LM. Structural characterization and tissue-specific expression of the mouse glucose-6-phosphate dehydrogenase gene. DNA Cell Biol. 1998 Mar;17(3):283-291.
56. Franzè A, Ferrante MI, Fusco F, Santoro A, Sanzari E, Martini G, Ursini MV. Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter. FEBS Lett. 1998 Oct 23;437(3):313-318.
57. Ho YS, Howard AJ, Crapo JD. Cloning and sequence of a cDNA encoding rat glucose-6-phosphate dehydrogenase. Nucleic Acids Res. 1988 Aug 11;16(15):7746.
58. Glock GE, McLean P. Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissues and tumours. Biochem J. 1954 Jan;56(1):171-175.
59. Grigor MR, Gain KR. The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats. Biochem J. 1983 Nov 15;216(2):515-518.
60. Xu W, Westwood B, Bartsocas CS, Malcorra-Azpiazu JJ, Indrák K, Beutler E. Glucose-6 phosphate dehydrogenase mutations and haplotypes in various ethnic groups. Blood. 1995 Jan 1;85(1):257-263.
61. Nagel RL, Roth EF Jr. Malaria and red cell genetic defects. Blood. 1989 Sep; 74(4):1213-1221.
62. Greene LS: G6PD deficiency as protection against falcipurum malaria: An epidemiologic critique of population and experimental studies. Yearbook Phys Anthropol. 1993; 17:153.
63. Motulsky AG, Campbell-Kraut JM. Population genetics of glucose-6-phosphate dehydrogenase deficiency of the red cell, in Blumberg BS (ed): Proceedings of the Conference on Genetic Polymorphisms and Geographic Variations in Disease, New York, NY, Grune & Stratton, 1961, p 159
64. Rakitzis ET, Papandreou FT: Ascorbate-induced generation of free radical species in normal and glucose-6- phosphate dehydrogenase-deficient erythrocytes. Biochem SOC Trans1989; 17:371
65. Rakitzis ET: Test for glucose-6-phosphate dehydrogenase deficiency. Lancet 1964;2, 1182.
66. Beutler E, Blume KG, Kaplan JC, Löhr GW, Ramot B, Valentine WN. International Committee for Standardization in Haematology: recommended screening test for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Br J Haematol. 1979 Nov;43(3):465-467.
67. Beutler E, Dern RJ, Alving AS. The hemolytic effect of primaquine. IV. The relationship of cell age to hemolysis. J Lab Clin Med. 1954 Sep;44(3):439-442.
68. Piomelli S, Corash LM, Davenport DD, Miraglia J, Amorosi EL. In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency. J Clin Invest. 1968 Apr; 47(4):940-948.
69. Beutler E. Isolation of the aged. Blood Cells. 1988;14(1):1-5.
70. Gulati S, Singh S, Narang A, Bhakoo ON. Exchange transfusion with G-6-PD deficient donor blood causes exaggeration of neonatal hyperbilirubinemia. Indian Pediatr. 1989 May; 26(5):499-501.
71. Beutler E, Yeh M, Fairbanks VF. The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker. Proc Natl Acad Sci U S A. 1962 Jan 15;48:9-16.
72. Beutler E, Baluda MC. The separation of glucose-6-phosphate dehydrogenase-deficient erythrocytes from the blood of heterozygotes for glucose-6-phosphate dehydrogenase deficiency. Lancet. 1964 Jan 25;1(7326):189-192.
73. Beutler E, Dern RJ, Baluda MC: A new technique for the ascertainment of heterozygotes for G-6-PD deficiency. Proceedings of the Ninth Congress of the European Society of Haematology, Lisbon, Portugal, Karger.1963; p 675
74. Beutler E, Baluda MC. Methemoglobin reduction. Studies of the interaction between cell populations and of the role of methylene blue. Blood. 1963 Sep; 22:323-333.
75. Fairbanks VF, Lampe LT. A tetrazolium-linked cytochemical method for estimation of glucose-6-phosphate dehydrogenase activity in individual erythrocytes: applications in the study of heterozygotes for glucose-6-phosphate dehydrogenase deficiency. Blood. 1968 May; 31(5):589-603.
76. Vogels IM, Van Noorden CJ, Wolf BH, Saelman DE, Tromp A, Schutgens RB, Weening RS. Cytochemical determination of heterozygous glucose-6-phosphate dehydrogenase deficiency in erythrocytes. Br J Haematol. 1986 Jun; 63(2):402-405.
77. Toniolo D, Martini G, Migeon BR, Dono R. Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA. EMBO J. 1988 Feb; 7(2):401-406.
78. Battistuzzi G, D'Urso M, Toniolo D, Persico GM, Luzzatto L. Tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3′ end of the gene. Proc Natl Acad Sci U S A. 1985 Mar; 82(5):1465-1469.
79. Curnutte JT, Hopkins PJ, Kuhl W, Beutler E. Studying X inactivation. Lancet. 1992 Mar 21;339(8795):749.
80. Fairbanks VF, Nepo AG, Beutler E, Dickson ER, Honig G. Glucose-6-phosphate dehydrogenase variants: reexamination of G6PD Chicago and Cornell and a new variant (G6PD Pea Ridge) resembling G6PD Chicago. Blood. 1980 Feb; 55(2):216-220.
81. Hirono A, Beutler E. Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-). Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3951-3954.
82. Kurdi-Haidar B, Mason PJ, Berrebi A, Ankra-Badu G, al-Ali A, Oppenheim A, Luzzatto L. Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East. Am J Hum Genet. 1990 Dec; 47(6):1013-1019.
83. Chang JG, Chiou SS, Perng LI, Chen TC, Liu TC, Lee LS, Chen PH, Tang TK. Molecular characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency by natural and amplification created restriction sites: five mutations account for most G6PD deficiency cases in Taiwan. Blood. 1992 Aug 15;80(4):1079-1082.
84. Hsia YE, Miyakawa F, Baltazar J, Ching NS, Yuen J, Westwood B, Beutler E. Frequency of glucose-6-phosphate dehydrogenase (G6PD) mutations in Chinese, Filipinos, and Laotians from Hawaii. Hum Genet. 1993 Nov; 92(5):470-476.
85. Beutler E, Kuhl W, Fox M, Tabsh K, Crandall BF. Prenatal diagnosis of glucose-6-phosphatedehydrogenase deficiency. Acta Haematol. 1992;87(1-2):103- 104.
86. Hermiston ML, Mentzer WC. A practical approach to the evaluation of the anemic child. Pediatr Clin North Am. 2002 Oct; 49(5):877-891.
87. Glucose-6-phosphate dehydrogenase deficiency. Accessed online July 20, 2005,at:http://www.thedoctorslounge.et/clinlounge/diseases/hematology/g6pd.htm
88. Sharma SC, Sharma S, Gulati OP. Pycnogenol prevents haemolytic injury in G6PD deficient human erythrocytes. Phytother Res. 2003 Jun; 17(6):671-674.
89. Babior BM. NADPH oxidase: an update. Blood. 1999 Mar 1;93(5):1464-1476.
90. Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, Lambeth JD. Cell transformation by the superoxide-generating oxidase Mox1. Nature. 1999 Sep 2;401(6748):79-82.
91. Sadowski IJ, Wright JA, Israels LG. A permeabilized cell system for studying regulation of aryl hydrocarbon hydroxylase: NADPH as rate limiting factor in benzo(a)pyrene metabolism. Int J Biochem. 1985;17(9):1023-1025.
92. Imlay JA, Linn S. DNA damage and oxygen radical toxicity. Science. 1988 Jun 3;240(4857):1302-1309.
93. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26; 420(6917): 860-867.
94. Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med. 2002 Nov;8(11):1211-1217.
95. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature. 1996 Mar 14;380(6570):168-171.
96. Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest. 2003 Jan; 111(2):163-169.
97. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000 Nov 9;408(6809):239-247.
98. Schwartz AG, Pashko LL. Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004 Apr; 3(2):171-187.
99. Tian WN, Braunstein LD, Pang J, Stuhlmeier KM, Xi QC, Tian X, Stanton RC. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem. 1998 Apr 24;273(17):10609-10617.
100. Raineri R, Levy HR. On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase. Biochemistry. 1970 May 26; 9(11):2233-2243.
101. Ho HY, Cheng ML, Lu FJ, Chou YH, Stern A, Liang CM, Chiu DT. Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med. 2000 Jul 15;29(2):156-169.
102. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet. 1998 Jun; 19(2):171-174.
103. Cheng ML, Ho HY, Wu YH, Chiu DT. Glucose-6-phosphate dehydrogenase- deficient cells show an increased propensity for oxidant-induced senescence. Free Radic Biol Med. 2004 Mar 1;36(5):580-591.
104. Cheng ML, Ho HY, Liang CM, Chou YH, Stern A, Lu FJ, Chiu DT. Cellular glucose-6-phosphate dehydrogenase (G6PD) status modulates the effects of nitric oxide (NO) on human foreskin fibroblasts. FEBS Lett. 2000 Jun 23;475(3):257-262.
105. Filosa S, Fico A, Paglialunga F, Balestrieri M, Crooke A, Verde P, Abrescia P, Bautista JM, Martini G. Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress. Biochem J. 2003 Mar 15; 370 (Pt 3): 935-943.
106. Paglialunga F, Fico A, Iaccarino I, Notaro R, Luzzatto L, Martini G, Filosa S. G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch. Blood. 2004 Nov 15;104(10):3148-3152.
107. Longo L, Vanegas OC, Patel M, Rosti V, Li H, Waka J, Merghoub T, Pandolfi PP, Notaro R, Manova K, Luzzatto L. Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J. 2002 Aug 15;21(16):4229-4239.
108. Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP. Inhibition of influenza infection by glutathione. Free Radic Biol Med. 2003 Apr 1;34(7):928-936.
109. Beck MA, Levander OA, Handy J. Selenium deficiency and viral infection. J Nutr. 2003 May; 133(5 Suppl 1):1463S-1467S.
110. Sulis E. G.-6-P.D. deficiency and cancer. Lancet. 1972 May 27;1(7761):1185.
111. Kuo W, Lin J, Tang TK. Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer. 2000 Mar 15;85(6):857-864.
112. Forteleoni G, Argiolas L, Farris A, Ferraris AM, Gaetani GF, Meloni T. G6PD deficiency and breast cancer. Tumori. 1988 Dec 31;74(6):665-667.
113. Pisano M, Cocco P, Cherchi R, Onnis R, Cherchi P. Glucose-6-phosphate dehydrogenase deficiency and lung cancer: a hospital based case-control study. Tumori. 1991 Feb 28;77(1):12-15.
114. Cocco P, Todde P, Fornera S, Manca MB, Manca P, Sias AR. Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency. Blood. 1998 Jan 15;91(2):706-709.
115. Cheng AJ, Chiu DT, See LC, Liao CT, Chen IH, Chang JT. Poor prognosis in nasopharyngeal cancer patients with low glucose-6-phosphate-dehydrogenase activity. Jpn J Cancer Res. 2001 May; 92(5): 576-581.
116. Wan GH, Tsai SC, Chiu DT. Decreased blood activity of glucose-6-phosphate dehydrogenase associates with increased risk for diabetes mellitus. Endocrine. 2002 Nov; 19(2):191-195.
117. Assaf AA, Tabbara KF, el-Hazmi MA. Cataracts in glucose-6-phosphate dehydrogenase deficiency. Ophthalmic Paediatr Genet. 1993 Jun; 14(2): 81-86.
118. Tsai KJ, Hung IJ, Chow CK, Stern A, Chao SS, Chiu DT. Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphatedehydrogenase-deficient granulocytes. FEBS Lett. 1998 Oct 9;436(3):411-414.
119. Ho HY, Cheng ML, Chiu DT. G6PD - an old bottle with new wine. Chang Gung Med J. 2005 Sep; 28(9):606-612.