Pycnogenol® prevents haemolytic injury in G6PD deficient human erythrocytes

Phytotherapy Research

Volumn 17, Issue 6, 2003, Pages 671-674

  Sharma, S C ^a   Sharma, S ^a   Gulati, O P ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Horphag Research   (Switzerland)

Author keywords

Bioflavonoids; Free radicals; G6PD deficient erythrocytes; Haemolysis; Pinus pinaster; Pycnogenol ; Quinine; t BHP

Indexed keywords

FREE RADICAL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEMOGLOBIN; PEROXIDE; PINUS PINASTER EXTRACT; PLANT EXTRACT; PYCNOGENOL; QUININE; SCAVENGER; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; DIAGNOSTIC AGENT; FLAVONOID; PYCNOGENOLS;

ARTICLE; BARK; CELL DAMAGE; CELL PROTECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HUMAN; HUMAN CELL; MALE; OPTICAL DENSITY; OXIDATIVE STRESS; SPECTROPHOTOMETRY; X CHROMOSOME LINKED DISORDER; BLOOD; DRUG EFFECT; GLYCOGEN STORAGE DISEASE TYPE 1; PHYTOTHERAPY; PINE;

CINCHONA PUBESCENS; PINUS PINASTER;

ERYTHROCYTES; FLAVONOIDS; GLYCOGEN STORAGE DISEASE TYPE I; HEMOLYSIS; HUMANS; PHYTOTHERAPY; PINUS; PLANT BARK; PLANT EXTRACTS; QUININE; TERT-BUTYLHYDROPEROXIDE;

EID: 0037787758     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1334     Document Type: Article

References (43)

1. Beutler E, Lisker R, Kuhl W. 1990. Molecular biology of G6PD variants. Biomed Biochim Acta 49: S236-S241.
2. Beutler E. 1994. G6PD deficiency. Blood 84: 3613-3636.
3. Bozzi A, Parisi M, Strom R. 1996. Erythrocyte glutathione determination in the diagnosis of glucose-6-phosphate dehydrogenase deficiency. Biochem Mol Biol Int 40: 561-569.
4. Brzezinska-Slebodzinska E. 2001. Erythrocyte osmotic fragility test as the measure of defence against free radicals in rabbits of different age. Vet Hung 49: 413-419.
5. Chen MJ, Sorette MP, Chiu DT, Clark MR. 1991. Prehemolytic effects of hydrogen peroxide and t-butylhydroperoxide on selected red cell properties. Biochim Biophys Acta 1066: 193-200.
6. Chiu D, Lubin B, Shohet S. 1982a. Peroxidative reactions in red cell biology. In Free Radicals in Biology, Pryor W (ed.). New York: Academic Press; 5: 115-160.
7. Chiu D, Vichinsky E, Yee M et al. 1982b. Peroxidation, vitamin E, and sickle-cell anemia. Ann N Y Acad Sci 393: 323-335.
8. Cho KJ, Yun CH, Yoon DY et al. 2000. Effect of bioflavonoids extracted from the bark of pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide stimulated RAW 264.7. Toxicol Appl Pharmacol 168: 64-71.
9. Clemens MR, Einsele H, Waller HD. 1983. Oxidant damage of normal and glucose 6-phosphate dehydrogenase (G6PD)-deficient red blood cells is enhanced by iron-EDTA complex. Biochem Int 7: 281-290.
10. Cruz-Silva MM, Madeira VM, Almeida LM, Custodio JB. 2002. Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis. Toxicol In Vitro 15: 615-622.
11. Cybulska B, Bolard J, Seksek O et al. 1995. Identification of the structural elements of amphotericin B and other polyene macrolide antibiotics of the hepteane group influencing the ionic selectivity of the permeability pathways formed in the red cell membrane. Biochim Biophys Acta 1240: 167-178.
12. Elstner FE, Kleber E. 1990. Radical scavenger properties of leucocyanidin. In Flavonoids in Biology and Medicine III: Current Issues in Flavonoid Research, Das NP (ed.). Singapore: Natl Univ of Singapore Press; 227-235.
13. Grinstein S, Foskett JK. 1990. Ionic mechanisms of cell volume regulation in leukocytes. Annu Rev Physiol 52: 399-414.
14. Hochstein P. 1988. Perspectives on hydrogen peroxide and drug-induced hemolytic anemia in glucose-6-phosphate Dehydrogenase deficiency. Free Radic Biol Med 5: 387-392.
15. Hoffman JF. 1992. On red blood cells, hemolysis and resealed ghosts. Adv Exp Med Biol 326: 1-15.
16. Ingrosso D, Cimmino A, D'Angelo S et al. 2002. Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes: role of oxidative stress. Eur J Biochem 269: 2032-2039.
17. Iwai K, Hirono A, Matsuoka H et al. 2001. Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia. Hum Genet 108: 445-449.
18. Jackson JK, Winternit CI, Burt HM, 1996. Mechanism of hemolysis of human erythrocytes exposed to monosodium urate monohydrate crystals. Preliminary characterization of membrane pores. Biochim Biophys Acta 128: 45-52.
19. Jain SK, Palmer M. 1996. Effect of glucose-6-phosphate dehydrogenase deficiency on reduced and oxidized glutathione and lipid peroxide levels in the blood of African-Americans. Clin Chim Acta 253: 181-183.
20. Knopik-Skrocka A, Bielawski J. 2002. The mechanism of the hemolytic activity of polyene antibiotics. Cell Mol Biol Lett 7: 31-48.
21. Koster JF, Slee RG. 1983. Lipid peroxidation of human erythrocyte ghosts induced by organic hydroperoxides. Biochim Biophys Acta 752: 233-239.
22. Kuriyama H, Kitamura K, Nabata H. 1995. Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev 47: 387-573.
23. Lee GR, Bithell TC, Forester J et al. 1993. Glucose-6-phosphate dehydrogenase deficiency and related deficiencies involving the pentose phosphate pathway and glutathione metabolism. In Wintrobe's Clinical Hematology 1, Lee GR (ed.). Philadelphia, PA: Lea & Fibiger; 1006-1016.
24. Liu TZ, Lin TF, Hung IJ et al. 1994. Enhanced susceptibility of erythrocytes deficient in glucose-6-phosphate dehydrogenase to alloxan/glutathione-induced decrease in red cell deformability. Life Sci 55: PL 55-60.
25. Lotitio SB, Fraga CG. 1998. (+)-Catechin prevents human plasma oxidation. Free Radic Biol Med 24: 435-441.
26. Luzzatto L, Mehta A, Meloni T, 1995. Haemoglobinuria and haptoglobin in G6PD deficiency. Br J Haematol 91: 511-512.
27. Miki M, Tamai H, Mino M et al. 1987. Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by alpha-tocopherol. Arch Biochem Biophys 258: 373-380.
28. 2(+)-ATPase. Biochem Biophys 278: 416-424.
29. Oppenheim A, Jury CL, Rund D et al. 1993. G6PD Mediterranean accounts for the high prevalence of G6PD deficiency in Kurdish Jews. Hum Genet 91: 293-294.
30. Neto EC, Portal L, Ferreira LF. 1999. G6PD deficiency in an unselected Brazilian population. Southeast Asian J Trop Med Public Health 30 (suppl 2): 87.
31. Packer L, Rimbach G, Virgili F. 1999. Antioxidant activity and biologic properties of a procyanidin-Rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27: 704-724.
32. Puppo A, Halliwell B. 1988. Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent? Biochem J 249: 185-190.
33. Rohn TT, Hinds TR, Vincenzi FF. 1993. Inhibition of the Ca pump of intact red blood cells by t-butyl hydroperoxide: importance of glutathione peroxidase. Biochim Biophys Acta 1153: 67-76.
34. Sharma SC, Gulati OP. 1988. Erythrocyte stabilizing effect of a new flavonoid Bencianol. Br J Pharmacol 93: 209 [abstract].
35. Sharma SC. 1992. Protection of human erythrocytes by lazaroids. Br J Pharmacol 106: 114 [abstract].
36. Sharma SC, Sharma S, Gulati OP. 2001. Pycnogenol, an antioxidant with French connection and ability for erythrocyte Protection. Irish J Med Sci 170: 106-107.
37. Sharma SC, Sharma S, Gulati OP. 2002. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res (in publication).
38. + channel blocker (quinine) on the dopamine decrease induced by selective D3 agonist (7-OH-DPAT) in the rat striatum. Nihon Shinkei Seishin Yakurigaku Zasshi 21: 145-156.
39. Sukumar S, Colah R, Mohanty D. 2002. G6PD gene mutations in India producing drug-induced haemolytic anaemia. Br J Haematol 116: 671-672.
40. Tavazzi B, Amorini AM, Fazzina G et al. 2001. Oxidative stress induces impairment of human erythrocyte energy metabolism through the Oxygen radical-mediated direct activation of AMP-deaminase. J Biol Chem 276: 48083-48092.
41. van der Zee J, Dubbelman TM, van Steveninck J. 1985. Peroxide-induced membrane damage in human erythrocytes. Biochim Biophys Acta 818: 38-44.
42. Virgili F, Kobuchi H, Packer L. 1998. Procyanidins extracted from Pinus maritima (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine Raw 264.7 macrophages. Free Rad Biol Med 24: 1120-1129.
43. Yamamoto Y, Niki E, Kamiya Y et al. 1986. Free radical chain oxidation and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E. J Nutr Sci Vitaminol (Tokyo) 32: 475-479.