Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors

Journal of the Royal Society Interface

Volumn 5, Issue 25, 2008, Pages 929-939

  Augst, Alexander ^a,e   Marolt, Darja ^a,d   Freed, Lisa E ^a   Vepari, Charu ^b   Meinel, Lorenz ^a,b,f   Farley, Michelle ^a   Fajardo, Robert ^c   Patel, Nipun ^c   Gray, Martha ^a   Kaplan, David L ^b   Vunjak Novakovic, Gordana ^a,d  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b Tufts University   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Mail Code 8904 ^*  (United States)

^e HARVARD UNIVERSITY   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bioreactor; Chondrogenesis; Osteochondral composite; Osteogenesis; Silk scaffold

Indexed keywords

BIOCONVERSION; BIOREACTORS; BIOTECHNOLOGY; BONE; CARBON FIBER REINFORCED PLASTICS; CARTILAGE; CELL CULTURE; CELLS; CHEMICAL REACTORS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC RADIOGRAPHY; INDUSTRIAL CHEMICALS; LIGAMENTS; MAGNETIC FIELDS; MAGNETIC RESONANCE IMAGING; MAGNETISM; MEDICAL IMAGING; RESONANCE; SCAFFOLDS; SILK; TISSUE; TOMOGRAPHY;

BONE CONSTRUCTS; BONE FORMATION; BONE MARROW (BM); BONE-LIKE TISSUE; CULTURE MEDIUM; EARLY STAGES; ENGINEERED CARTILAGE; HUMAN MESENCHYMAL STEM CELLS (HMSC); IN-VITRO; MAGNETIC (CE); MECHANICAL ASSAYS; MICRO-COMPUTERIZED TOMOGRAPHY (MICRO-CT); OSTEOCHONDRAL; OSTEOGENIC MEDIUM; REGULATORY FACTOR (IRF); TISSUE CONSTRUCTS; TISSUE FORMATION;

TISSUE ENGINEERING;

BONE MORPHOGENETIC PROTEIN 2; CALCIUM; GLYCEROL 2 PHOSPHATE; INSULIN; REGULATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BIOREACTOR; BONE DEVELOPMENT; BONE MARROW BIOPSY; BONE MINERALIZATION; CELL ISOLATION; CHONDROGENESIS; COMPOSITE MATERIAL; COMPUTER ASSISTED TOMOGRAPHY; CULTURE MEDIUM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL TRANSPLANTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; REGULATORY MECHANISM; ROTATING BIOREACTOR; SILK; SILK SCAFFOLD; TISSUE ENGINEERING;

BIOTECHNOLOGY; CELLS; CHEMICAL REACTORS; CHEMICALS; COMPOSITES; MAGNETIC FIELDS; MAGNETIC PROPERTIES; RADIOGRAPHY; RESONANCE; SCAFFOLDS; SILK; TISSUE;

EID: 45849093211     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2007.1302     Document Type: Article

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