Relationship between methylenetetrahydrofolate reductase polymorphism and homocysteine levels in women with recurrent pregnancy loss: A nutrigenetic perspective;Relación entre los polimorfismos de la metilen-tetrahidrofolato- reductasa y los niveles de homocisteína en mujeres con pérdida gestacional recurrente: Perspectiva desde la nutrigenética

Nutricion Hospitalaria

Volumn 23, Issue 3, 2008, Pages 277-282

  Cardona, H ^a   Cardona Maya, W ^a   Gomez J G ^a   Castaneda S ^a   Gomez J M ^a   Bedoya, G ^a   Alvarez L ^a   Torres, J D ^a   Tobon L I ^a   Cadavid J, Ángela ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Homocysteine; MTHFR; Nutrition; Recurrent pregnancy loss

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; RECURRENT DISEASE; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; ADULT; FEMALE; HOMOCYSTEINE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION; NUTRIGENOMICS; POLYMORPHISM, GENETIC; PREGNANCY;

EID: 45849088400     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Stirrat GM. Recurrent miscarriage. Lancet 1990; 336 (8716):673-675.
2. Regan LM, Mollica JS, Rezaie AR, Esmon CT. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C J Biol Chem 1997; 272(42):26279-26284.
3. Kutteh WH, Wester R, Kutteh CC. Multiples of the median: an alternative method for reporting antiphospholipid antibodies in women with recurrent pregnancy loss. Obstet Gynecol 1994; 84(5):811-815.
4. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995; 346(8987):1395-1398.
5. Nelen WL, Bulten J, Steegers EA, Blom HJ, Hanselaar AG, Eskes TK. Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss. Hum Reprod 2000; 15(4):954-960.
6. Aubard Y, Genet D, Eyraud JL, Clavere P, Tubiana-Mathieu N, Philippe HJ. Impact of screening on breast cancer detection. Retrospective comparative study of two periods ten years apart. Eur J Gynaecol Oncol 2002; 23(1):37-41.
7. Holmes ZR, Regan L, Chilcott I, Cohen H. The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss. Br J Haematol 1999; 105(1):98-101.
8. Foka ZJ, Lambropoulos AF, Saravelos H, Karas GB, Karavida A, Agorastos T y cols. Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod 2000; 15(2):458-462.
9. Unfried G, Griesmacher A, Weismuller W, Nagele F, Huber JC, Tempfer CB. The C677T polymorphism of the methylenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage. Obstet Gynecol 2002; 99(4):614-619.
10. Wouters MG, Boers GH, Blom HJ, Trijbels FJ, Thomas CM, Borm GF y cols. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60(5):820-825.
11. Coumans AB, Huijgens PC, Jakobs C, Schats R, De Vries JI, Van Pampus MG y cols. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum Reprod 1999; 14(1):211-214.
12. Zighetti ML, Chantarangkul V, Tripodi A, Mannucci PM, Cattaneo M. Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography. Haematologica 2002; 87(1):89-94.
13. Ausbel FM, Brent R, Kingston RE, Moore DD, Serdman JG, Smith JA, Struhl, K. Current Protocols in Molecular Biology. 1-3. John Wiley and Sons Inc, USA; 1996.
14. Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C y cols. Coexistence of hereditary homocystinuria and factor V Leiden - effect on thrombosis. N Engl J Med 1996; 334(12):763-768.
15. Pepe G, Camacho Vanegas O, Giusti B, Brunelli T, Marcucci R, Attanasio M y cols. Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase. Am J Hum Genet 1998; 63(3):917-920.
16. Hegele RA, Tully C, Young TK, Connelly PW. V677 mutation of methylenetetrahydrofolate reductases and cardiovascular disease in Canadian Inuit. Lancet 1997; 349(9060):1221-1222.
17. Córdoba-Porras A, Sánchez-Quesada JL, González- Sastre F, Ordóñez-Llanos J, Blanco-Vaca F. Susceptibility of plasma low- and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinemia. J Mol Med 1996; 74(12):771-776.
18. Camacho Vanegas O, Giusti B, Restrepo Fernández CM, Abbate R, Pepe G. Frequency of factor V (FV) Leiden and C677T methylenetetrahydrofolate reductase (MTHFR) mutations in Colombians. Thromb Haemost 1998; 79(4):883-884.
19. Torres J, Cardona H, Álvarez L, Cardona-Maya W, Castañeda SA, Quintero-Rivera F y cols. Inherited Thrombophilia in a Group of patients with Deep Vein Thrombosis. American Journal of Hematology 2006; 81:933-937.
20. Couto E, Barini R, Zaccaria R, Annicchino-Bizzacchi JM, Passini Junior R, Pereira BG y cols. Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia? Sao Paulo Med J 2005; 123(1):15-20.
21. Otero A, Pou-Ferrari R, Pons E, Lens D, E. DL, Dellepiane M y cols. Trombofilia y pérdida recurrente de embarazo. Rev Med Uruguay 2004; 20:106-113.
22. Lee RM, Brown MA, Ward K, Nelson L, Branch DW, Silver RM. Homocysteine levels in women with antiphospholipid syndrome and normal fertile controls. J Reprod Immunol 2004; 63(1):23-30.
23. Córdoba A, Arbeláez L, Castañeda S. Concentración plasmática de homocisteína en ayunas en individuos sanos de la ciudad de Medellín. Acta Med Colomb 2002; 27:196-197.
24. Gropper S, Smith J, Groff J. Advanced Nutrition and Human Metabolism; Thomson Wadsworth Publishing, USA; 2005.
25. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R y cols. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 1994; 91(14):6369-6373.
26. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996; 27(3):517-527.
27. Cortese C, Motti C. MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr 2001; 4(2B):493-497.
28. Ubbink JB, Vermaak WJ, Van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994; 124(10):1927-1933.
29. 6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 1993; 57(1):47-53.
30. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C -> T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002; 288(16):2023-2031.
31. Scott JM. Homocysteine and cardiovascular risk. Am J Clin Nutr 2000; 72(2):333-334.
32. 12, Pantothenic Acid, Biotin and Choline. En: Food and Nutrition Borrad. Washington DC; 1998. pp. 196-305.
33. Cortés F, Mellado C, Hertrampf E, Alliende A, Castillo S. Frecuencia de los defectos de cierre del tubo neural en las maternidades públicas de Santiago durante el año 1999. Rev Med Chile 2001; 129:277-284.
34. Nitsche F, Alliende MA, Santos JL, Pérez F, Santa María L, Hertrampf E, Cortés F. Frecuencia del polimorfismo C677T de la 5, 10-metilentetrahidrofolato reductasa (MTHFR) en mujeres chilenas madres de afectados con espina bífida y en controles normales. Rev Med Chile 2003; 131(12):1399-1404.