Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: A new path to thrombophilia?

Sao Paulo Medical Journal

Volumn 123, Issue 1, 2005, Pages 15-20

  Couto, Egle ^a,b   Barini, Ricardo ^a   Zaccaria, Renata ^a   Annicchino Bizzacchi, Joyce Maria ^a   Passini Jr , Renato ^a   Gonçalves Pereira, Belmiro ^a   Gama da Silva, José Carlos ^a   Pinto e Silva, João Luiz ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b NONE   (Brazil)

Author keywords

Anticardiolipin antibodies; Antiphospholipid syndrome; Methylenetetrahydrofolate reductase (NADPH2) thrombophilia; Thrombosis

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; LUPUS ANTICOAGULANT; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; PROTEIN C; PROTEIN S; PROTHROMBIN;

ADULT; ALLELE; ARTICLE; BRAZIL; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FISHER EXACT TEST; GENE FREQUENCY; GENE MUTATION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; RECURRENT ABORTION; REGRESSION ANALYSIS; SPONTANEOUS ABORTION; THROMBOPHILIA; VEIN THROMBOSIS;

EID: 17644402426     PISSN: 15163180     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-31802005000100004     Document Type: Article

References (40)

1. Regan L, Braude PR, Trembath PL. Influence of past reproductive performance on risk of spontaneous abortion. BMJ. 1989;299(6698)541-5.
2. Qureshi F, Yang Y, Jaques SM, et al. Anti-DNA antibodies cross-reacting with laminin inhibit trophoblast attachment and migration: implications for recurrent pregnancy loss in SLE patients. Am J Reprod Immunol. 2000;44(3):136-42.
3. Mecacci F, Parretti E, Cioni R, et al. Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclampsia. J Reprod Immunol. 2000;46(1):39-50.
4. Hughes GR. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. Br Med J (Clin Res Ed). 1983;287(6399):1088-9.
5. Triplett DA. Obstetrical complications associated with antiphospholipid antibodies. In: Coulam CB, Faulk WP, McIntyre JA, editors. Immunological obstetrics. London: Norton Medical Books; 1992. p. 377-403.
6. Younis JS, Ohel G, Brenner B, Haddad S, Lanir N, Ben-Ami M. The effect of thrombophylaxis on pregnancy outcome in patients with recurrent pregnancy loss associated with factor V Leiden mutation. BJOG. 2000; 107(3):415-9.
7. Lockshin MD, Qamar T, Levy RA. Anticardiolipin and related antibodies: thrombosis and fetal death. In: Scott JS, Bird HA, editors. Pregnancy, autoimmunity and connective tissue disorders. Oxford: Oxford University Press; 1990. p. 185-211.
8. MacLean MA, Cumming GP, McCall F, Walker ID, Walker JJ. The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages. Br J Obstet Gynaecol. 1994;101(2):103-6.
9. Sugi T, Katsunuma J, Izumi S, McIntyre JA, Makino T. Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses. Fertil Steril. 1999;71(6):1060-65.
10. Hossain AM, Whitman GF, Khan I. Kininogen present in rat reproductive tissues is apparently synthesized by the liver, not by the reproductive system. Am J Obstet Gynecol. 1995;173(3 Pt 1):830-4.
11. Matsubayashi H, Sugi T, Arai T, et al. Different antiphospholipid antibody specificities are found in association with early repeated pregnancy loss versus recurrent IVF-failure patients. Am J Reprod Immunol. 2001;46(5):323-9.
12. Wouters MG, Boers GH, Blom HJ, et al. Hyperhomocysteinemia: a risk factor in women, with unexplained recurrent early pregnancy loss. Fertil Steril. 1993;60(5):820-5.
13. Coumans AB, Huijgens PC, Jakobs C, et al. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum Reprod. 1999;14(1):211-4.
14. Nelen WL, Blom HJ, Steegers EA, den Heijer M, Thomas CM, Eskes TK. Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol. 2000;95(4):519-24.
15. De Stefano V, Finazzi G, Mannucci PM. Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood. 1996;87(9):3531-44.
16. Lane DA, Mannuci PM, Bauer KA, et al. Inherited thrombophilia: Part 1. Thromb Haemost. 1996;76(5):651-62.
17. Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women, with complications of pregnancy. N Engl J Med. 1999;340(1):9-13.
18. Ogasawara MS, Aoki K, Katano K, Ozki Y, Suzumori K. Factor XII but not protein C, protein S, antithrombin III, or factor XIII is a predictor of recurrent miscarriage. Fertil Steril. 2001;75(5):916-9.
19. Galstian A, Beer AE, Roberts JM, Coulam CB, Faulk WP. Immunology of preeclampsia. In: Coulam CB, Faulk WP, McIntyre JA, editors. Immunological obstetrics. London: Norton Medical Books; 1992. p. 503-15.
20. Dahlback B. The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thromb Res. 1995;77(1):1-43.
21. Dizon-Townson DS, Kinney S, Branch DW, Ward K. The factor V Leiden mutation is not a common cause of recurrent, miscarriage. J Reprod Immunol. 1997;34(3):217-23.
22. Foka ZJ, Lambropoulos AF, Saravelos H et al. Factor V leiden and prothrombin G20210A mutations, but not methylentetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod. 2000;15(2):458-62.
23. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88(10):3698-703.
24. Blumenfeld Z, Brenner B. Thrombophilia-associated pregnancy wastage. Fertil Steril. 1999;72(5):765-74.
25. Triplett DA, Barna L, Unger G. Laboratory identifications of lupus anticoagulants. In: XIVth Congress of the International Society on Thrombosis and Haemostasis. New York, New York, USA. July 4-9, 1993. New York. New York Hilton & Towers; 1993. p. 70-9.
26. a ed. NewYork: Cold Spring Harbor, Cold Spring Harbor Laboratory; 1989.
27. Ruiz AM, Kwak JY, Kwak FM, Beer AE. Impact of age on reproductive outcome in women with recurrent spontaneous abortions and infertility of immune etiology. Am J Reprod Immunol. 1996;35(4).408-14.
28. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet. 1995;346(8983):1133-4.
29. Arruda VR, von Zuben PM, Soares MC, Menezes R, Annichino-Bizzacchi JM, Costa FF. Very low incidence of Arg506-->Gin mutation in the factor V gene among the Amazonian Indians and the Brazilian black population. Thromb Haemost. 1996;75(5):860-1.
30. Rai R, Regan L, Hadley E, Dave M, Cohen H. Second-trimester pregnancy loss is associated with activated C resistance. Br J Haematol. 1996;92(2):489-90.
31. Balasch J, Reverter JC, Fábregues F, et al. First-trimester repeated abortion is not associated with activated protein C resistance. Hum Reprod. 1997;12(5):1094-7.
32. Branch DW, Silver R, Pierangeli S, van Leeuwen I, Harris EN. Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome. Obstet Gynecol. 1997;89(4):549-55.
33. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348(9032):913-6.
34. Bucciarelli P, Rosendaal FR, Tripodi A, et al. Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study. Arterioscler Thromb Vasc Biol. 1999;19(4):1026-33.
35. Dulícek P, Chrobák L, Kalousek I, Pesavová L, Pecka M, Stránsky P. Is factor V Leiden a risk factor for fetal loss? Acta Medica (Hradec Kralove). 1999;42(3):93-6.
36. Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review Placenta. 1999;20(7):519-29.
37. Murphy RP, Donoghue C, Nallen RJ, et al. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphism in pregnancy. Arterioscler Thromb Vasc Biol. 2000;20(1):266-70.
38. Lissak A, Sharon A, Fruchter O, Kassel A, Sanderovitz J, Abramovici H. Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss. Am J Obstet Gynecol. 1999;181(1):126-30.
39. Phillips MD. Interrelated risk factors for venous thromboembolism. Circulation. 1997;95(7):1749-51.
40. Topping J, Quenby S, Farquharson R, Malia R, Greaves M. Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome. Hum Reprod. 1999;14(1):224-8.