Quantitative structure-pharmacokinetic parameters relationships (QSPKR) analysis of antimicrobial agents in humans using simulated annealing k-nearest-neighbor and partial least-square analysis methods

Journal of Pharmaceutical Sciences

Volumn 93, Issue 10, 2004, Pages 2535-2544

  Ng, Chee ^a   Xiao, Yunde ^b   Putnam, Wendy ^a   Lum, Bert ^a   Tropsha, Alexander ^b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

k nearest neighbor; Partial least square; QSPKR

Indexed keywords

AMIKACIN; AMOXICILLIN; AMPICILLIN; ANTIINFECTIVE AGENT; AZLOCILLIN; CARBENICILLIN; CEFALOTIN; CEFAMANDOLE; CEFAPIRIN; CEFAZOLIN; CEFMENOXIME; CEFMETAZOLE; CEFODIZIME; CEFONICID; CEFOPERAZONE; CEFORANIDE; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFSULODIN; CEFTAZIDIME; CEFTIZOXIME; CEFTRIAXONE; CEFUROXIME; GENTAMICIN; MECILLINAM; MEZLOCILLIN; NETILMICIN; TOBRAMYCIN; UNINDEXED DRUG;

ANALYTICAL ERROR; ARTICLE; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MATHEMATICAL MODEL; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE; STEADY STATE;

EID: 4844227862     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20117     Document Type: Article

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