In vitro characterization of the enzymes involved in the metabolism of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound

Archives of Pharmacal Research

Volumn 31, Issue 6, 2008, Pages 764-770

  Lee, Sang Kyu ^a   Kim, Ju Hyun ^b   Seo, Young Min ^b   Kim, Hye Chun Hwa ^b   Kang, Mi Jeong ^b   Jeong, Hye Gwang ^c   Lee, Eung Seok ^b   Jeong, Tae Cheon ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Yeungnam University   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Carbonyl reductase; FPP 3; In vitro; LC ESI MS; Metabolism; Phase I

Indexed keywords

1 FURAN 2 YL 3 PYRIDIN 2 YL PROPENONE; 1-FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE; 11BETA HYDROXYSTEROID DEHYDROGENASE; ALCOHOL DEHYDROGENASE; ANTIINFLAMMATORY AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; FURAN DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROPANE; PYRIDINE DERIVATIVE;

ANIMAL; ARTICLE; BIOTRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; KINETICS; LIVER; LIVER MICROSOME; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOTRANSFORMATION; ENZYME INHIBITORS; FURANS; KINETICS; LIVER; MALE; MICROSOMES, LIVER; NADP; PROPANE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 45749127459     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1224-3     Document Type: Article

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