Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 28, Issue 3, 2008, Pages 276-280

  Zuo, Shi ^a,b   Luo, Jian ^a   Liu, Minfeng ^a   Xu, Lining ^a   Dong, Jingqing ^a   Guo, Wei ^a   Zou, Shengquan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUIZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Antisense; Apoptosis; Cholangiocarcinma; DNA methyltransferase 1; DNA methyltransferase 36

Indexed keywords

DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B;

ANIMAL; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; BILIARY TRACT TUMOR; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL PROLIFERATION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BILIARY TRACT NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION;

EID: 45749083796     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-008-0310-7     Document Type: Article

References (20)

1. Das P M, Singal R. DNA methylation and cancer. J Clin Oncol, 2004,22(22):4632
2. Egger G, Liang G, Aparicio A et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature, 2004,429(6990):457
3. Ballestar E, Esteller M. The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis, 2002,23(7):1103
4. Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci, 2004,61(19-20):2571
5. Tang Q B, Sun H W, Zou S Q. 5-aza-2-deoxycytidine inhibits the growth of bile duct cancer cell line in vivo and in vitro. Chin J Gen Surg, 2004,19(5):295
6. Tang Q B, Sun H W, Zou S Q. Effects of 5-aza-2-deoxycytidine on the growth and apoptosis of bile duct cancer cell line. J Huazhong Univ Sci Tech (Health Sci), 2004;33(1):34
7. Vertino P M, Yen R W, Gao J et al. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA(cytosine-5)-methyltransferase. Mol Cell Biol, 1996,16(8):4555
8. Lu R, Fang J Y, Zhu H Y et al. Effect of recombinant DNA methylferase 1 plasmid on the expression of tumor associated gene in human colon cancer cell line. Chin J Dig, 2004,24(2):67
9. Rhee I, Bachman K E, Park B H et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature, 2002,416(6880):552
10. Leu Y W, Rahmatpanah F, Shi H et al. Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Cancer Res, 2003,63(19):6110
11. Xu X L, Yu J, Zhang H Y. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis, 2004,10(23):3441
12. Curtis C D, Goggins M. DNA methylation analysis in human cancer. Methods Mol Med, 2004,103:123
13. Tozawa T, Tamura G, Honda T et al. Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients. Cancer Sci, 2004,95(9):736
14. Lind G E, Thorstensen L, Lovig T et al. A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer, 2004,3:28.
15. Mizuno S, Chijiwa T, Okamura T et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood, 2001,97(5):1172
16. Robertson K D, Uzvolgyi E, Liang G et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res, 1999,27(11):2291
17. Robert M F, Morin S, Beaulieu N et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet, 2003,33(1):61
18. Fang J Y, Yang L, Zhu H Y et al. 5-Aza-2′-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines. Chin Med J (Engl), 2004,117(1):99
19. Brown R, Plumb J A. Demethylation of DNA by decitabine in cancer chemotherapy. Expert Rev Anticancer Ther, 2004,4(4):501
20. Daskalakis M, Nguyen T T, Nguyen C et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood, 2002,100(8):2957