7-Bromoindirubin-3′-oxime uncovers a serine protease-mediated paradigm of necrotic cell death

Biochemical Pharmacology

Volumn 76, Issue 1, 2008, Pages 39-52

  Ribas, Judit ^a   Yuste, Víctor J ^d   Garrofé Ochoa, Xènia ^a   Meijer, Laurent ^c   Esquerda, Josep E ^b   Boix, Jacint ^a  

^a Universitat de Lleida Facultat de Medicina Sabadell   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

^c CNRS   (France)

^d Institut de Neurociències   (Spain)

Author keywords

AIF; Cell death; Indirubin; Mitochondria; Proteases

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; 5 BROMOINDIRUBIN 3' OXIME; 7 BROMOINDIRUBIN 3' OXIME; APOPTOSIS INDUCING FACTOR; CALPAIN; CASPASE; CASPASE INHIBITOR; CATHEPSIN; OXIME DERIVATIVE; PROTEIN BAK; PROTEIN BAX; Q VD OPH; SERINE PROTEINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CELL POPULATION; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DNA DEGRADATION; DNA INTEGRATION; DOSE RESPONSE; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

EID: 45449102255     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.03.023     Document Type: Article

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