K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling

Journal of Dermatological Science

Volumn 51, Issue 2, 2008, Pages 89-102

  Youm, Jong Kyung ^a,c   Jo, Hae ^b   Hong, Jeong Hee ^b   Shin, Dong Min ^b   Kwon, Mi Jung ^c   Jeong, Se Kyoo ^a,c   Park, Byeong Deog ^c   Choi, Eung Ho ^d   Lee, Seung Hun ^a,e  

^a Yonsei University   (South Korea)

^b Oral Science Research Center   (South Korea)

^c NeoPharm Co Ltd   (South Korea)

^d Yonsei University Wonju College of Medicine   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

Author keywords

Ca2+ signaling; Fibroblast proliferation; Skin anti aging; Sphingosine kinase; Sphingosine 1 phosphate

Indexed keywords

CALCIUM; CYTOKERATIN 5; DECANE; DIHYDROXYSPHINGOSINE; DIMETHYLSPHINGOSINE; ENZYME ACTIVATOR; FILAGGRIN; FURA 2; INVOLUCRIN; K6PC 5; LORICRIN; N (1,3 DIHYDROXYISOPROPYL) 2 HEXYL 3 OXODECANAMIDE; PROCOLLAGEN; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; SPHINGOSINE KINASE; THAPSIGARGIN;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN SYNTHESIS; CUTANEOUS PARAMETERS; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; FIBROBLAST; FLUORESCENCE; GENETIC TRANSFECTION; HAIRLESS MOUSE; HUMAN; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN DISEASE; SKINFOLD;

AGING; AMIDES; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; FIBROBLASTS; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED HRS; MODELS, ANIMAL; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROCOLLAGEN; SKIN; SPHINGOSINE;

EID: 45449086652     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2008.03.002     Document Type: Article

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