Synthesis and antispasmodic activity evaluation of bis-(papaverine) analogues

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 3, 2004, Pages 316-321

  Kaur, Jaskiran ^a   Ghosh, Narendra Nath ^b   Chandra, Ramesh ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Antispasmodic activity; Dimer; Papaverine; Piperazine; Tetrahydropapaverine; Urea

Indexed keywords

CYANIC ACID DERIVATIVE; HETEROCYCLIC COMPOUND; N,N BIS[2 CARBAMOYL 1 (3,4 DIMETHOXYBENZYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINYL]PIPERAZINE; PAPAVERINE DERIVATIVE; PIPERAZINE DERIVATIVE; SPASMOLYTIC AGENT; TETRAHYDROPAPAVERINE; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; N,N' BIS (2 CARBAMOYL 1 (3,4 DIMETHOXYBENZYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINYL)PIPERAZINE; N,N'-BIS-(2-CARBAMOYL-1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINYL)PIPERAZINE; PAPAVERINE; TETRAHYDROISOQUINOLINE DERIVATIVE;

AMPLIFIER; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FORCE TRANSDUCER; ILEUM CONTRACTION; NONHUMAN; SMOOTH MUSCLE RELAXATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; GUINEA PIG; IC 50; ILEUM; IN VITRO STUDY; MUSCLE CONTRACTION; SMOOTH MUSCLE; SYNTHESIS;

ANIMALS; GUINEA PIGS; ILEUM; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PAPAVERINE; PARASYMPATHOLYTICS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 4544385539     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.316     Document Type: Article

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