A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates

Pharmacotherapy

Volumn 23, Issue 5, 2003, Pages 585-591

  DiCenzo, Robert ^a,b,c   Forrest, Alan ^b   Slish, Judianne C ^b   Cole, Carol ^a   Guillet, Ronnie ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ALGORITHM; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; BIRTH WEIGHT; CLINICAL TRIAL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSIMETRY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; GESTATIONAL AGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; NEWBORN; NEWBORN INTENSIVE CARE; OPEN STUDY; POPULATION MODEL; PRESCRIPTION; PROSPECTIVE STUDY; SEPSIS;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BAYES THEOREM; BIRTH WEIGHT; DRUG ADMINISTRATION SCHEDULE; GENTAMICINS; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LINEAR MODELS; MODELS, BIOLOGICAL; PROSPECTIVE STUDIES; SEPSIS;

EID: 0037693941     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.23.5.585.32196     Document Type: Article

References (24)

1. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Once- versus twice-daily gentamicin dosing in neonates ≥ 34 weeks' gestation: cost-effectiveness analyses. Pediatrics 1999;103:594-8.
2. Lundergan FS, Glasscock GF, Kim EH, Cohen RS. Once-daily gentamicin dosing in newborn infants. Pediatrics 1999;103:1228-34.
3. Hayani KC, Hatzopoulos FK, Frank AL, et al. Pharmacokinetics of once-daily dosing of gentamicin in neonates. J Pediatr 1997;131:76-80.
4. Langlass TM, Mickle TR. Standard gentamicin dosage regimen in neonates. Am J Health-Syst Pharm 1999;56:440-3.
5. Skopnik H, Heimann G. Once daily aminoglycoside dosing in full term neonates. Pediatr Infect Dis J 1995;14:71-2.
6. de Alba Romero C, Castillo EG, Secades CM, Lopez JR, Lopez LA, Valiente PS. Once daily gentamicin dosing in neonates. Pediatr Infect Dis J 1998;17:1169-71.
7. Rocha MJ, Almeida AM, Afonso E, et al. The kinetic profile of gentamicin in premature neonates. J Pharm Pharmacol 2000;52:1091-7.
8. Glover ML, Shaffer CL, Rubino CM, et al. A multicenter evaluation of gentamicin therapy in the neonatal intensive care unit. Pharmacotherapy 2001;21(1):7-10.
9. Murphy JE, Austin ML, Frye RF. Evaluation of gentamicin pharmacokinetics and dosing protocols in 195 neonates. Am J Health-Syst Pharm 1998;55:2280-8.
10. Guillet R, Cole C, Slish J, DiCenzo R. Gentamicin dosing in neonates as a function of gestational age and birth weight. Presented at the annual meeting of the Pediatric Academic Society, Baltimore, MD, April 28-May 1, 2001.
11. D'Argenio DZ, Schumitzky A. A program package for simulation and parameter estimation in pharmacokinetic systems. Comp Programs Biomed 1979;9:115-34.
12. D'Argenio DZ, Schumitzky A. ADAPT 11 users guide, release 4: biomedical simulations resource. Los Angeles: University of Southern California, 1997.
13. Akaike H. A Bayesian extension of the minimum AIC procedure of autoregressive model fitting. Biometrika 1979;66:237-42.
14. Steimer JL, Mallet A, Golmard JL, Boisvieux JF. Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model. Drug Metab Rev 1984;15:265-92.
15. de Cos MA, Gomez-Ullate J, Gomez F, Armijo JA. Time course of trough serum gentamicin concentration in preterm and term neonates. Clin Pharmacokinet 1992;23(5):391-401.
16. Semchuk W, Shevchuk YM, Sankaran K, Wallace SM. Prospective, randomized controlled evaluation of a gentamicin loading dose in neonates. Biol Neonate 1995;67:13-20.
17. Hoff DS, Jensen PD. Pediatric pharmacotherapy. In: Mueller BA, Bertch KE, Dunsworth TS, et al, eds. Pharmacotherapy selfassessment program, 4th ed. Book 9: pediatrics nephrology module. Kansas City, MO: American College of Clinical Pharmacy, 2002:1-23.
18. Noone P, Parsons TMC, Rattison JR, et al. Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. BMJ 1974;1:477-81.
19. Moore RD, Smith CR, Lietman PS. Association of aminoglycoside plasma levels with therapeutic outcome of gram-negative pneumonia. Am J Med 1984;77:657-62.
20. Solomkin JS, Dellinger EP, Christou NV, et al. Results of a multicenter trial comparing imipenem/cilastatin to tobramycin/dindamycin for intra-abdominal infections. Ann Surg 1990;212:581-91.
21. Dahlgran JG, Anderson ET, Hewitt WL. Gentamicin blood levels: a guide to nephrotoxicity. Antimicrob Agents Chemother 1975;8:58-62.
22. Mawer GE, Ahmad R, Dobbs SM, et al. Prescribing aids for gentamicin. Br J Clin Pharmacol 1974;1:45-50.
23. Zaske DE, Bootman JL, Solem LB, et al. Increased burn patient survival with individualized dosages of gentamicin. Surgery 1982;91:142-9.
24. Zaske DE. Aminoglycosides. In: Evans WE, Schentag JJ, Jusko WJ, eds. Applied pharmacokinetics: principles of therapeutic drug monitoring, 3rd ed. Spokane, WA: Applied Therapeutics, 1992:14-1-14-47.