The ion targets of arrhythmias induced by ouabain and aconitine in guinea pig and rat ventricular myocytes

Yaoxue Xuebao

Volumn 39, Issue 5, 2004, Pages 328-332

  Gong, Dong Mei ^a   Shan, Hong Li ^a   Zhou, Yu Hong ^a   Dong, De Li ^a   Yang, Bao Feng ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

Aconitine; APD; Arrhythmia; Calcium current; Ouabain; Outward potassium current

Indexed keywords

ACONITINE; OUABAIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE MODEL; GUINEA PIG; HEART ARRHYTHMIA; HEART VENTRICLE; ION CHANNEL; MUSCLE CELL; NONHUMAN; PATCH CLAMP; RAT;

ACONITINE; ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; CALCIUM CHANNELS, L-TYPE; CELL SEPARATION; FEMALE; GUINEA PIGS; HEART VENTRICLES; MALE; MYOCYTES, CARDIAC; OUABAIN; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, WISTAR;

EID: 4544363646     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Furukawa Y, Xue YX, Chiba S, et al. Effects of zatebradine on ouabain-, two-stage coronary ligation- and epinephrine-induced ventricular tachyarrhythmias [J]. Eur J Pharmacol, 1996,300(3):203-210.
2. Nakamura M, Xue Y, Eto K, et al. Antiarrhythmic effects of optical isomers of disopyramide on canine ventricular arrhythmias [J]. J Cardiovasc Pharmacol, 1996,27(3):368-375.
3. + current in guinea pig ventricular myocytes [J]. Acta Pharmacol Sin, 1998,19(3):269-272.
4. Du GY, Ye WH, Lu F, et al. Effects of 6, 7-dimethoxycoumarin on experimental arrhythmia [J]. Acta Pharmacol Sin, 1993,14(11):16-18.
5. Wang J, Feng J, Nattel S. Class III antiarrhythmic drug action in experimental atrial fibrillation: differences in reverse use dependence and effectiveness between d-sotalol and the new antiarrhythmic drug ambassilide [J]. Circulation, 1994,90(4):2032-2040.
6. + current in guinea pig cardiac myocytes [J]. Am J Physiol Heart Circ Physiol, 2000,279(1):130-138.
7. Xiang JZ. Pharmacology [M]. Beijing: Science Publishing House, 2002.238-253.
8. + channels, toxicity and antinociceptive properties [J]. Eur J Pharmacol, 1997,337(2-3):165-174.
9. Su DF, Miu CY, Wang YM. Development of Pharmacology [M]. Beijing: People's Medical Publishing House, 2001.126-130.
10. k, and HERG channels of cardiac myocytes [J]. Acta Pharmacol Sin, 2001,22(2):125-131.
11. Ca contributes to rate-dependent changes of action potentials in human ventricular myocytes [J]. Am J Physiol, 1999,276:98-106.
12. + currents in mammalian ventricular myocytes [J]. Acta Pharmacol Sin, 1999,20(11):961-969.
13. Yang BF, Xu CQ, Li YR, et al. Inhibitory effect of artemisinin on cloned inward rectifier potassium channels [J]. Chin J Pharmacol Toxicol, 1999,13(4):245-248.
14. Yeih DF, Chiang FT, Huang SK. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone [J]. Heart, 2000,84(4):8.
15. Yang BF, Shan HL, Zhou YH, et al. Construction of a new model for screening antiarrhythmic drugs [J]. Chin Pharmacol Bull, 2003,19(2):217-221.