Effects of RP58866 on transmembrane K+ currents in mammalian ventricular myocytes

Acta Pharmacologica Sinica

Volumn 20, Issue 11, 1999, Pages 961-969

  Yang, Bao Feng ^a   Li, Gui Rong ^b   Xu, Chang Qing ^a   Nattel, Stanley ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Anti arrhythmia agents; Arrhythmia; Benzopyrans; Cultured cells; Inhibitory concentration 50; Ion channels; Myocardium; Patch clamp techniques; Potassium channels; RP58866

Indexed keywords

AMIODARONE; DOFETILIDE; POTASSIUM CHANNEL; SOTALOL; TERIKALANT;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; GUINEA PIG; HEART MUSCLE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT;

EID: 0032762935     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Spnelli W, Hoffrnan BF. Mechanisms of terination of reentrant atrial arrhythmias by class I and class III anti-arrhythmic agents. Circ Res 1989; 65: 1665-79.
2. Wang ZG, Feng JL, Nattel S. Class III anti-arrhythmic drug action in experimental atrial fibrillation; differences in reverse use dependence and effectiveness between d-sotalol and the new anti-arrhythmic drug ambassilide. Circulation 1994; 90: 2032-40.
3. Colastsky TJ, Follmer CH, Starmer CF. Channel specificity in anti-arrhythmic drug action: mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation 1990; 82: 2235-42.
4. Balser JR, Bennett PB, Roden DM. Time-dependent outward current in guinea pig ventricular myocytes: gating kinetics of the delayed rectifier. J Gen Physiol 1990; 96: 835-63.
5. + current: differential sensitivity to block by class III anti-arrhythmic agents. J Gen Physiol 1990; 96: 195-215.
6. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegel PKS. Isoproterenol antagonizes prolongation of refractory period by the class III anti-arrhythmic agent E-4031 in guinea pig myocytes. Circ Res 1991; 68: 77-81.
7. + current by dofetilide. Circ Res 1993; 72: 75-83.
8. Gwilt M, Arrowsmith JE, Blackburn KJ, Burges RA, Cross PE, Dalrymple HW, et al. UK-68, 798: a novel, potent and highly selective class III anti-arrhythmic agent which blocks potassium channels in cardiac cells. J Pharmacol Exp Ther 1991; 256: 318-24.
9. kl blockade; a new anti-arrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate. Circulation 1993; 87: 1979-89.
10. + current in heart cells. (abstract) Circulation 1989; 80 (Suppl II): II -607.
11. Ca, contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am J Physiol 1999; 276: H98-H106.
12. Hiraoka M, Kawano S. Calcium-sensitive and insensitive transient outward current in rabbit ventricular myocytes. J Physiol (Lond) 1989; 410: 187-212.
13. Balser JR, Bennett PB, Hondeghem LB, Roden DM. Suppression of time-dependent outward current in guinea pig ventricular myocytes: Actions of guinidine and amiodarone. Circ Res 1991; 69: 519-29.
14. Josephson IR, Sanchez-Chapula J, Brown AM. Early outward current in rat single ventricular cells. Circ Res 1984; 54: 157-62.
15. + dependence. J Physiol (Lond) 1991; 435: 395-420.
16. Colatsky TJ, Follmer CH. K-channel blockers and activators in cardiac arrhythmias. Cardiovasc Drug Dev 1989; 7: 199-209.