Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation

Archives of Toxicology

Volumn 78, Issue 8, 2004, Pages 460-466

  Hayashi, Morimichi ^a,b   Ohnota, Hideki ^a   Tamura, Toru ^a   Kuroda, Junji ^a   Shibata, Nobuo ^a   Akahane, Masuo ^a   Moriwaki, Hisataka ^b   Machida, Noboru ^c   Mitsumori, Kunitoshi ^c  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Chemoprevention; Liver carcinogenesis; Rat; Thyroid hormone; Thyromimetic

Indexed keywords

DIETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; KAT 681; MALONIC ACID DERIVATIVE; N (2 FLUORENYL)ACETAMIDE; N [4 [3 [(4 FLUOROPHENYL)HYDROXYMETHYL] 4 HYDROXYPHENOXYL] 2,5 DIMETHYLPHENYL]MALONAMIC ACID SODIUM; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; ENZYME ACTIVITY; LIVER CELL CARCINOMA; LIVER RESECTION; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

2-ACETYLAMINOFLUORENE; ANIMALS; APOPTOSIS; BODY WEIGHT; CARCINOGENS; CELL PROLIFERATION; DIETHYLNITROSAMINE; EATING; GLUTATHIONE TRANSFERASE; HEPATECTOMY; HEPATOCYTES; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MALONATES; ORGAN SIZE; PHENYL ETHERS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344; THYROID GLAND;

EID: 4544332173     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0561-4     Document Type: Article

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