Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: Insights on normal metabolism of HDL and LDL gained from the NP-C mutation

Journal of Lipid Research

Volumn 38, Issue 12, 1997, Pages 2422-2435

  Shamburek, Robert D ^c   Pentchev, Peter G ^c   Zech, Loren A ^c   Blanchette Mackie, Joan ^c   Carstea, Eugene D ^c   VandenBroek, Julie M ^a   Cooper, Patricia S ^a   Neufeld, Edward B ^c   Phair, Robert D ^b   Brewer Jr , H Bryan ^c   Brady, Roscoe O ^c   Schwartz, Charles C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BioInformatics Services   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Bile; Cholesterol metabolism; Intracellular transport; Kinetic model; Lipoprotein

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CHROMOSOME 18Q; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LIPOPROTEIN METABOLISM; LYSOSOME; NIEMANN PICK DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ADULT; BILE; CHOLESTEROL; CHOLESTEROL ESTERS; FIBROBLASTS; HISTOCYTOCHEMISTRY; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALE; MEVALONIC ACID; MUTATION; NIEMANN-PICK DISEASES;

EID: 15644375176     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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