Enterotoxins, enteric nerves, and intestinal secretion

Current Gastroenterology Reports

Volumn 6, Issue 3, 2004, Pages 177-180

  Farthing, Michael J G ^a   Casburn Jones, Anna ^b   Banks, Matthew R ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIARRHEAL AGENT; ARGININE; CALMODULIN INHIBITOR; CHOLERA TOXIN; ENTEROTOXIN; ESCHERICHIA COLI ENTEROTOXIN; HEXAMETHONIUM; IGMESINE; LIDOCAINE; N(G) NITROARGININE METHYL ESTER; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE INHIBITOR; SEROTONIN; SEROTONIN ANTAGONIST; SUBSTANCE P ANTAGONIST; TETRODOTOXIN; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; ZALDERIDE MALEATE; NITRIC OXIDE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

AUTOREGULATION; CAUSE OF DEATH; DEHYDRATION; DIARRHEA; DRUG TARGETING; ENTEROCHROMAFFIN CELL; ESCHERICHIA COLI; HUMAN; INTESTINE INNERVATION; INTESTINE SECRETION; NERVE STIMULATION; NERVOUS SYSTEM FUNCTION; NOTE; TOXIN SYNTHESIS; TRAVELLER DIARRHEA; VIBRIO CHOLERAE; INNERVATION; INTESTINE; INTESTINE MUCOSA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SECRETION;

CHOLERA TOXIN; ENTERIC NERVOUS SYSTEM; ENTEROTOXINS; HUMANS; INTESTINAL MUCOSA; INTESTINES; NITRIC OXIDE; SUBSTANCE P; VASOACTIVE INTESTINAL PEPTIDE;

EID: 4544315318     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-004-0001-x     Document Type: Note

References (36)

1. Farthing MJG: Dehydration and rehydration in children. In Hydration Throughout Life. Edited by Arnaud MJ. Paris: John Libbey Eurotext; 1998:159-173.
2. Rao MC: Molecular mechanisms of bacterial toxins. In Enteric Infection. Edited by Farthing MJG, Keusch GT. London: Chapman and Hall; 1989:87-104.
3. Field M, Fao MC, Chang EB: Intestinal electrolyte transport and diarrhoeal disease. N Engl J Med 1989, 321: 879-883.
4. Field M, Rao MC, Chang EB: Intestinal electrolyte transport and diarrheal disease. N Eng J Med 1989, 321: 800-806.
5. Rao MC: Toxins which activate guanylate cyclase: heat-stable enterotoxins. In Microbial Toxins and Diarrhoeal Disease. Ciba Foundation Symposium 112. Edited by Evered D, Whelan J, London: Pitman; 1985:74-93.
6. Hubel KA: Intestinal nerves and ion transport: stimuli, reflexes and responses. Am J Physiol 1985, 248: G261-G271.
7. Jodal M: Neuronal influence on intestinal transport. J Intern Med 1990, 228: 125-132.
8. Cooke HJ: Neurotransmitters in neuronal reflexes regulating intestinal secretion. Ann N Y Acad Sci 2000, 915: 77-80.
9. Pothoulakis C: The role of neuroenteric hormones in intestinal infectious diseases. Curr Opin Gastroenterol 2000, 16: 536-540.
10. Zhang M, Zeng CO-Y, Morris AP, Estes MK: A functional NS94 enterotoxin peptide secreted from rotavirus-infected cells. J Virol 2000, 74: 11663-11670.
11. Mohan KVK, Dermody TS, Atreya CD: Mutations selected in rotavirus enterotoxin NSP4 depend on the context of its expressionl. Virology 2000, 275: 125-132.
12. Morris AP, Estes MK: Microbes and microbial toxins: Paradigms for microbial-mucosal interactions. VIII. Pathological consequences of rotavirus infection and its enterotoxin. Am J Physiol 2001, 281: G303-G310.
13. Farthing MJG: Enterotoxins and the enteric nervous system: a fatal attraction. Int J Med Microbiol 2000, 290: 85-90.
14. Jodal M: Neuronal influence on intestinal transport. J Intern Med 1990, 228: 125-132.
15. Cassuto J, Fahrenkrug J, Jodal M, et al.: Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxinb. Gut 1981, 22: 958-963.
16. Turvill JL, Connor P, Farthing MJG: The inhibition of cholera toxin-induced 5-HT release by the 5-HT3 receptor antagonist, granisetron, in the rat. Br J Pharmacol 2000, 130: 1031-1036.
17. Mourad FH, O'Donnell LJD, Dias JA, et al.: Role of 5-hydroxytryptamine type 3 receptors in rat intestinal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxins. Gut 1995, 37: 340-345.
18. Beubler E, Horina G: 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology 1990, 99: 83-89.
19. Buchheit KH: Inhibition of cholera toxin-induced intestinal secretion by the 5-HT3 receptor antagonist ICS 205-930. Arch Pharmacol 1989, 339: 704-705.
20. Ehere AJ, Hinterleitner TA, Petritsch W, et al.: Effect of 5-hydroxytryptamine antagonists on cholera toxin-induced secretion in the human jejunum. Eur J Clin Invest 1994, 24: 664-668.
21. Bearcroft CP, Andre E, Farthing MJG: In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: a segmental perfusion. Aliment Pharm Ther 1997, 11: 1109-1114.
22. Turvill JL, Farthing MJG: Effect of granisetron on cholera toxin-induced enteric secretion. Lancet 1997, 349: 1293.
23. Turvill JL, Farthing MJG: Selective 5-hydroxytryptamine type 4 (5-HT4) antagonist inhibits cholera toxin (CT) but not E. coli heat labile toxin (LT)-induced secretion [abstract]. Gastroenterology 1996, 110: A368.
24. Turvill JL, Connor P, Farthing MJG: Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Gastroenterology 2000, 119: 1037-1044.
25. Mourad FH, Nassar C: Effect of vasoactive intestinal peptide (VIP) antagonism on rat jejunal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxins. Gut 2000, 47: 382-386.
26. Banks MR, Farthing MJG, Robberecht P, Burleigh DE: Anti-secretory actions of a novel vasoactive intestinal polypeptide receptor antagonist [abstract]. Gastroenterology 2002, 122: A-254.
27. Turvill JL, Kasapidis P, Farthing MJG: The sigma ligand, igmesine, inhibits cholera toxin and Escherichia coli enterotoxin induced jejunal secretion in the rat. Gut 1999, 45: 564-569.
28. Mourad F, Turvill J, Farthing MJG: The role of nitric oxide in intestinal water and electrolyte transport. Gut 1999, 44: 143-147.
29. Mourad FH, O'Donnell LJD, Andre EA, et al.: L-arginine, nitric oxide and intestinal secretion: studies in rat jejunum in vivo. Gut 1996, 39: 539-544.
30. Turvill JL, Mourad FH, Farthing MJG: Proabsorptive and prosecretory roles for nitric oxide in cholera toxin induced secretion. Gut 1999, 44: 33-39.
31. Rolfe V, Levin RJ: Enterotoxin Escherichia coli STA activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum. J Physiol 1994, 475: 531-537.
32. Mourad FH, Barada KA, Abdel-Malak N, et al.: Interplay between nitric oxide and vasoactive intestinal polypeptide in inducing fluid secretion in rat jejunum. J Physiol 2003, 550: 863-871.
33. Lundgren O, Peregrin AT, Persson K, et al.: Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea. Science 2000, 287: 491-495.
34. Banks MR, Casburn-Jones AC, Farthing MJG: Cholera toxin (CT), Escherichia coli heat labile (LT) and heat stable toxin (STA) have an indirect effect on distal intestinal fluid transport in the rat small intestine [abstract]. Gut 2002 50(Suppl 2): A 69.
35. Casburn-Jones AC, Barnett SC, Fitzgerald UF, Farthing MJG: Cholera toxin (CT) Escherichia coli heat labile toxin (LT) and heat stable toxin (STA) have a direct effect on the neuronal-like PC12 cell line [abstract]. Gut 2002 50(Suppl 2): A26.
36. Ma T, Thiagarajah JR, Yang H, et al.: Thiazilinone CFTR inhibitor identified by high throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 2002, 110: 1651-1658.