Comparative scintigraphic assessment of the intragastric distribution and residence of cholestyramine, Carbopol 934P and sucralfate

International Journal of Pharmaceutics

Volumn 212, Issue 1, 2001, Pages 55-62

  Jackson, S J ^a,b   Bush, D ^a   Perkins, A C ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

Author keywords

Carbopol 934P; Cholestyramine; Gamma scintigraphy; Gastric residence; Ion exchange resin; Sucralfate

Indexed keywords

CARBOMER; COLESTYRAMINE; DUOLITE; SUCRALFATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG DISTRIBUTION; DRUG RETENTION; FEMALE; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; ION EXCHANGE; ISOTOPE LABELING; MALE; MEAN RESIDENCE TIME; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH ANTRUM; STOMACH EMPTYING; STOMACH FUNDUS; STOMACH MUCOSA; STOMACH SCINTISCANNING;

ADULT; CHOLESTYRAMINE; CROSS-OVER STUDIES; FEMALE; GASTRIC EMPTYING; HUMANS; MALE; MIDDLE AGED; POLYVINYLS; STOMACH; SUCRALFATE; TECHNETIUM;

EID: 0035808271     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00600-1     Document Type: Article

References (26)

1. In-vitro and in-vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal-tract using polyglycerol esters of fatty-acids and a poly(acrylic acid) derivative
2. Formulation and characterisation of a buccoadhesive erodible tablet for the treatment of oral lesions
3. Ion exchange resin delivery systems
4. Intragastric distribution of ion-exchange resins: A drug delivery system for the topical treatment of the gastric mucosa
5. In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems
6. Precorneal clearance of mucoadhesive microspheres from the rabbit eye
7. A comparison of the gastric retention of a sucralfate gel and a sucralfate suspension
8. Gl transit of potential bioadhesive formulations in man - A scintigraphic study
9. Drug-delivery by ion-exchange. 7. Release of acidic drugs from anionic-exchange resinate complexes
10. In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa
11. Effect of resin surface charge on gastric mucoadhesion and residence of cholestyramine
12. In vitro binding of drugs to colestipol hydrochloride
13. Sucralfate as a bioadhesive gastric intestinal retention system-preliminary evaluation
14. Use of Dowex-X2 ion exchange resin for preparation of sustained release diclofenac delivery system. 1. Preparation and release studies
15. Formulation parameters affecting the preparation and properties of microencapsulated ion-exchange resins containing theophylline
16. Detection of gastroduodenal ulcers using Tc-99m-labeled sucralfate
17. Effect of ion exchange resins on the drug release from matrix tablets
18. Effect of dose size, food and surface coating on the gastric residence and distribution of an ion exchange resin
19. Factors affecting in-vitro gastric mucoadhesion. 1. Test conditions and instrumental parameters
20. Gastric scintigraphy with labelled sucralfate compared with endoscopy and biopsy
21. Gastric retention of sucralfate gel and suspension in upper gastrointestinal-diseases
22. Radiolabelled sucralfate: A review of clinical efficacy
23. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery
24. An in-vitro method for buccal adhesion studies: Importance of instrument variables
25. Selective adherence of a sucralfate-tetracycline complex to gastric ulcers-implications for the treatment of Helicobacter-pylori