New nucleoside-based polymeric supports for the solid phase synthesis of ribose-modified nucleoside analogues

Synlett

Volumn , Issue 11, 2004, Pages 1975-1979

  De Napoli, Lorenzo ^a   Di Fabio, Giovanni ^a   D'Onofrio, Jennifer ^a   Montesarchio, Daniela ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Combinatorial chemistry; Mitsunobu reaction; Nucleosides; Nucleotides; Solid phase synthesis

Indexed keywords

DEOXYURIDINE DERIVATIVE; NUCLEIC ACID; NUCLEIC ACID BASE; OLIGONUCLEOTIDE; POLYMER; PURINE; PURINE NUCLEOSIDE DERIVATIVE; RIBOSE;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITSUNOBU REACTION; OXIDATION KINETICS; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; SOLID STATE; SYNTHESIS;

EID: 4544244942     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-830864     Document Type: Article

References (19)

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13. 4OH, 60°C, 18 h.
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15. In the synthesis of short oligomers 17-20, better crudes were obtained if the oxidation of the support was carried out before the coupling with the phosphoramidite building block.
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17. 4OH, 60°C, 18 h.
18. 4OH, 60°C, 18 h.
19. 2O): δ = 2.20, 1.92.