Combinatorial synthesis using nucleic acid-based (NAB(TM)) scaffold: Parallel solid-phase synthesis of nucleotide libraries

Tetrahedron Letters

Volumn 41, Issue 4, 2000, Pages 441-445

  Zhou, Wenqiang ^a   Roland, Arlène ^a   Jin, Yi ^a   Iyer, Radhakrishnan P ^a  

^a Origenix Technologies Inc   (Canada)

Author keywords

Combinatorial chemistry; Nucleic acid analogues; Nucleotides; Phosphoramidites

Indexed keywords

NUCLEOTIDE;

ARTICLE; CHEMICAL STRUCTURE; STRUCTURE ANALYSIS; SYNTHESIS; TECHNIQUE;

EID: 0034700839     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02089-4     Document Type: Article

References (10)

1. For selected publications on the combinatorial approach to drug discovery, see: (a) Geysen, H.; Meloen, R. H.; Barteling, S. J. Proc. Natl. Acad. Sci. USA, 1984, 81, 3998-4002; (b) Jung, G.; Beck-Sickinger, A. G. Angew. Chem., Intl. Ed. Engl. 1992, 31, 367-383; (c) Pavia, M. R.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387-396; (d) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385-1401; (e) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
2. For selected publications on the combinatorial approach to drug discovery, see: (a) Geysen, H.; Meloen, R. H.; Barteling, S. J. Proc. Natl. Acad. Sci. USA, 1984, 81, 3998-4002; (b) Jung, G.; Beck-Sickinger, A. G. Angew. Chem., Intl. Ed. Engl. 1992, 31, 367-383; (c) Pavia, M. R.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387-396; (d) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385-1401; (e) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
3. For selected publications on the combinatorial approach to drug discovery, see: (a) Geysen, H.; Meloen, R. H.; Barteling, S. J. Proc. Natl. Acad. Sci. USA, 1984, 81, 3998-4002; (b) Jung, G.; Beck-Sickinger, A. G. Angew. Chem., Intl. Ed. Engl. 1992, 31, 367-383; (c) Pavia, M. R.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387-396; (d) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385-1401; (e) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
4. For selected publications on the combinatorial approach to drug discovery, see: (a) Geysen, H.; Meloen, R. H.; Barteling, S. J. Proc. Natl. Acad. Sci. USA, 1984, 81, 3998-4002; (b) Jung, G.; Beck-Sickinger, A. G. Angew. Chem., Intl. Ed. Engl. 1992, 31, 367-383; (c) Pavia, M. R.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387-396; (d) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385-1401; (e) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
5. For selected publications on the combinatorial approach to drug discovery, see: (a) Geysen, H.; Meloen, R. H.; Barteling, S. J. Proc. Natl. Acad. Sci. USA, 1984, 81, 3998-4002; (b) Jung, G.; Beck-Sickinger, A. G. Angew. Chem., Intl. Ed. Engl. 1992, 31, 367-383; (c) Pavia, M. R.; Sawyer, T. K.; Moos, W. H. Bioorg. Med. Chem. Lett. 1993, 3, 387-396; (d) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385-1401; (e) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
6. For a recent review of nucleic acid-based compounds and their applications, see: Verma, S.; Eckstein, F. Annu. Rev. Biochem. 1998, 67, 99-134.
7. Beaucage, S. L.; Caruthers, M. H. Tetrahedron Lett. 1981, 22, 1859-1862.
8. For a review of phosphoramidite chemistry, see: Iyer, R. P., Beaucage, S. L. In Comprehensive Natural Products Chemistry Vol. 7: DNA and Aspects of Molecular Biology; Kool, E. T., Ed. Oligonucleotide synthesis. Elsevier Science: London, 1999; pp. 105-152.
9. Barone, A. D.; Tang, J.-Y.; Caruthers, M. H. Nucl. Acids Res. 1984, 12, 4051-4061.
10. Iyer, R. P.; Egan, W.; Regan, J. B.; Beaucage, S. L. J. Am. Chem. Soc. 1990, 112, 1253-1254.