Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations

Metabolism: Clinical and Experimental

Volumn 53, Issue 10, 2004, Pages 1309-1314

  Lin, Yuguang ^a   Rudrum, Mike ^a   Van Der Wielen, Reggy P J ^a   Trautwein, Elke A ^a   McNeill, Gerald ^b   Sierksma, Aafje ^a   Meijer, Gert W ^b  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b Loders Croklaan   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; HEXACOSANOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OCTACOSANOL; POLICOSANOL; TRIACYLGLYCEROL;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD CELL COUNT; BLOOD CHEMISTRY; BLOOD EXAMINATION; CACAO; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT FAILURE; TREATMENT OUTCOME; WHEAT GERM;

ADOLESCENT; ADULT; AGED; ANTICHOLESTEREMIC AGENTS; BILIRUBIN; CHOLESTEROL; DIET; DIETARY FATS; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FATTY ALCOHOLS; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; MIDDLE AGED; TRITICUM;

EID: 4544224336     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.05.006     Document Type: Article

References (30)

1. Arruzazabala M.L., Noa M., Menendez R., et al. Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia. Braz J Med Biol Res. 33:2000;835-840
2. Rodriguez-Echenique C., Mesa R., Mas R., et al. Effects of policosanol chronically administered in male monkeys (Macaca arctoides). Food Chem Toxicol. 32:1994;565-575
3. Janikula M. Policosanol A new treatment for cardiovascular disease? Altern Med Rev. 7:2002;203-217
4. Aleman C., Rodeiro I., Noa M., et al. One-year dog toxicity study of D-002, a mixture of aliphatic alcohols. J Appl Toxicol. 21:2001;179-184
5. Rodriguez M.D., Gamez R., Sanchez M., et al. Developmental toxicity of D-002 (a mixture of aliphatic primary alcohols) in rats and rabbits. J Appl Toxicol. 18:1998;313-316
6. Wang Y.W., Jones P.J., Pischel I., et al. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids. 38:2003;165-170
7. Arruzazabala M.L., Molina V., Mas R., et al. Antiplatelet effects of policosanol (20 and 40 mg/day) in healthy volunteers and dyslipidaemic patients. Clin Exp Pharmacol Physiol. 29:2002;891-897
8. Pons P., Rodriguez M., Robaina C., et al. Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. Int J Clin Pharmacol Res. 14:1994;27-33
9. Castano G., Fernandez L., Mas R., et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int J Clin Pharmacol Res. 22:2002;55-66
10. Arruzazabala M.L., Carbajal D., Mas R., et al. Cholesterol-lowering effects of policosanol in rabbits. Biol Res. 27:1994;205-208
11. Menendez R., Arruzazabala L., Mas R., et al. Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet. Br J Nutr. 77:1997;923-932
12. Ortensi G., Gladstein J., Valli H., et al. A comparative study of policosanol versus simvastatin in elderly patients with hypercholesterolemia. Curr Therapeut Res. 58:1997;390-401
13. Castano G., Mas R., Fernandez L., et al. Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolaemia. Drugs Aging. 20:2003;153-163
14. Menendez R., Fernandez S.I., Del Rio A., et al. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res. 27:1994;199-203
15. McCarty M.F. Policosanol safely down-regulates HMG-CoA reductase - Potential as a component of the Esselstyn regimen. Med Hypoth. 59:2002;268-279
16. Yatcilla M. Policosanols, cholesterol solution or controversial problem? Nutraceuticals World April. 2002;28-34
17. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:1972;499-502
18. Feunekes G.I., Van Staveren W.A., de Vries J.H., et al. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. Am J Clin Nutr. 58:1993;489-496
19. Weststrate J.A., Meijer G.W. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 52:1998;334-343
20. Aleman C.L., Puig M.N., Elias E.C., et al. Carcinogenicity of policosanol in mice an 18-month study. Food Chem Toxicol. 33:1995;573-578
21. Rodeiro I., Aleman C., Noa M., et al. Preclinical oral toxicology in rats of D-002, a natural drug with antiulcer effects. Drug Chem Toxicol. 21:1998;151-162
22. Gouni-Berthold I., Berthold H.K. Policosanol Clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J. 143:2002;356-365
23. Alcocer L., Fernandez L., Campos E., et al. A comparative study of policosanol versus acipimox in patients with type II hypercholesterolemia. Int J Tissue React. 21:1999;85-92
24. Batista J., Stusser R., Saez F., et al. Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. A 14-month pilot study. Int J Clin Pharmacol Ther. 34:1996;134-137
25. Canetti M., Moreira M., Mas R., et al. A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. Int J Clin Pharmacol Res. 15:1995;159-165
26. Castano G., Mas R., Arruzazabala M.L., et al. Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. Int J Clin Pharmacol Res. 19:1999;105-116
27. Arruzazabala M.D., Carbajal D., Mas R., et al. Effects of D-003, a new compound purified from sugarcane wax, on platelet aggregation in healthy volunteers - A randomised, double-blind clinical study. Clin Drug Invest. 23:2003;107-118
28. Cabrera L., Rivero B., Magraner J., et al. Stability studies of tablets containing 5 mg of policosanol. Boll Chim Farm. 142:2003;277-284
29. Mas R. Policosanol. Drugs Future. 25:2000;569-586
30. Menendez R., Amor A.M., Rodeiro I., et al. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Arch Med Res. 32:2001;8-12