Developmental toxicity of D-002 (a mixture of aliphatic primary alcohols) in rats and rabbits

Journal of Applied Toxicology

Volumn 18, Issue 5, 1998, Pages 313-316

  Rodríguez, María D ^a   Gámez, Rafael ^a   Sánchez, Maribel ^a   García, Haydee ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

Developmental toxicity; Policosanol; Rabbit; Rat

Indexed keywords

ALCOHOL DERIVATIVE; ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; D 002; PROPOLIS; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG SAFETY; EMBRYOTOXICITY; FEMALE; FETOTOXICITY; FETUS; FETUS DEATH; FETUS MALFORMATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT; SKELETON MALFORMATION; TERATOGENICITY;

ANIMALS; FATTY ALCOHOLS; FEMALE; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TERATOGENS;

EID: 0031684255     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(1998090)18:5<313::AID-JAT513>3.0.CO;2-8     Document Type: Article

References (12)

1. D. Carbajal, V. Molina, S. Valdés, L. Arruzazabala and R. Más, Anti-ulcer activity of higher primary alcohols of beeswax. J. Pharm. Pharmacol. 47, 731-733 (1995).
2. D. Carbajal, V. Molina, S. Valdés, L. Arruzazabala and R. Más, Possible mechanism cytoprotective of D-002 J. Pharm. Pharmacol. 48, 858-860 (1996).
3. D. Carbajal, V. Molina, S. Valdés, L. Arruzazabala, R. Más and J. Magraner, Anti-inflammatory activity of D-002: an active product isolated from beeswax. Prostagland. Leukotriene. Essent. Fatty Acids (in press).
4. I. Rodeiro, C. Alemán, R. Más, M. Noa, F. Briñis and C. Hernández, Toxicología aguda oral del D-002 en ratas Sprague-Dawley. Rev. CENIC Cienc. Biol 26, 34-36 (1995).
5. I. Rodeiro, unpublished work, Estudios de Toxicidad aguda del D-002 en roedores y no roedores (1996).
6. I. Rodeiro, C. Alemán, M. Noa, R. Menéndez, R. Más, C. Hernández and M. Garcia, Preclinical oral toxicology in rats of D-002, a natural drug with antiulcer effects. Drug Chem. Toxicol. 21, 151-162 (1998).
7. R. Kopf, D. Lorenz and E. Salewski, Procedure for staining Implantation sites of fresh rat uteri. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmacol. 247, 121-135 (1964).
8. J. L. Stuckhart and S. M. Poppe, Fresh visceral examination of rat and rabbit foetuses used in teratogenicity testing. Teratogen. Carcinogen. Mutagen. 4, 181-188 (1984).
9. A. B. Dawson, A note on the staining of the skeleton of cleared specimens with alizarin red S. Stain. Technol. 1, 123-124 (1926).
10. A. K. Palmer, Spontaneous malformations of the New Zealand White rabbit: the background to safety evaluation test. Lab. Anim. 2, 195-206 (1968).
11. K. S. Khera, Common foetal aberrations and their teratologic significance: a review. Fundam. Appl. Toxicol. 1, 13-18 (1981).
12. J. Manson and T. Kang, Test methods for assessing female reproductive and developmental toxicology. In Principles and Methods of Toxicology, ed. by A. W. Hayes, pp 311-359. Raven Press, New York (1989).