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• Iloeje UH, Yang HI, Su J, et al.: Predicting liver cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006, 130:678-686. This important population-based prospective study indicates that a high serum HBV DNA level in HBV carriers aged 30 to 65 years increases the risk of progression to cirrhosis after more than 10 years of follow-up.
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• Iloeje UH, Yang HI, Su J, et al.: Predicting liver cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006, 130:678-686. This important population-based prospective study indicates that a high serum HBV DNA level in HBV carriers aged 30 to 65 years increases the risk of progression to cirrhosis after more than 10 years of follow-up.
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•• Chen CJ, Yang HI, Su J, et al.: Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006, 295:65-73. This landmark REVEAL-HBV study documents that the higher the serum HBV DNA level at entry, the higher the risk of HCC over time in HBV carriers older than 30 years.
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•• Chen CJ, Yang HI, Su J, et al.: Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006, 295:65-73. This landmark REVEAL-HBV study documents that the higher the serum HBV DNA level at entry, the higher the risk of HCC over time in HBV carriers older than 30 years.
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• Iloeje UH, Yang HI, Jen CL, et al.: Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus Study Group: Risk and predictors of mortality associated with chronic hepatitis B infection. Clin Gastroenterol Hepatol 2007, 5:921-931. This study indicates that chronic HBV infection is associated with excess mortality risk and that this risk is strongly correlated with high serum HBV DNA levels.
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• Iloeje UH, Yang HI, Jen CL, et al.: Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus Study Group: Risk and predictors of mortality associated with chronic hepatitis B infection. Clin Gastroenterol Hepatol 2007, 5:921-931. This study indicates that chronic HBV infection is associated with excess mortality risk and that this risk is strongly correlated with high serum HBV DNA levels.
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Hepatitis B viral genotypes: Clinical relevance and molecular characteristics
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Kao JH: Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002, 17:643-650.
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•, An excellent review of the epidemiology of HBV genotypes and their implications on the natural history of HBV infection
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• Kao JH, Chen DS: HBV genotypes: epidemiology and implications regarding natural history. Curr Hepat Rep 2006, 5:5-13. An excellent review of the epidemiology of HBV genotypes and their implications on the natural history of HBV infection.
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•, A comprehensive review of the implications of HBV genotypes on the treatment of chronic HBV infection
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• Liu CJ, Kao JH, Chen DS: Therapeutic implications of hepatitis B virus genotypes. Liver Int 2005, 25:1097-1107. A comprehensive review of the implications of HBV genotypes on the treatment of chronic HBV infection.
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HBsAg seroclearance in asymptomatic carriers of high endemic areas: Appreciably high rates during a long-term follow-up
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Chu CM, Liaw YF: HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology 2007, 45:1187-1192.
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Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C
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Kao JH, Chen PJ, Lai MY, Chen DS: Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C. J Clin Microbiol 2002, 40:4068-4071.
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Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection
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Kao JH, Chen PJ, Lai MY, Chen DS: Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection. J Med Virol 2002, 68:216-220.
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Huang LR, Wu HL, Chen PJ, Chen DS: An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection. Proc Natl Acad Sci U S A 2006, 103:17862-17867.
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•• Ni YH, Chang MH, Chen PJ, et al.: Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007, 132:2340-2345. The first study to demonstrate the time sequences of viremia and ALT profiles from the immune tolerance phase to the immune clearance phase in child HBV carriers.
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•• Ni YH, Chang MH, Chen PJ, et al.: Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007, 132:2340-2345. The first study to demonstrate the time sequences of viremia and ALT profiles from the immune tolerance phase to the immune clearance phase in child HBV carriers.
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84984535989
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• Liu CJ, Chen PJ, Lai MY, et al.: Viral factors correlate with hepatitis B e antigen seroconverson in patients with chronic hepatitis B. Liver Int 2006, 26:949-955. An important study showing the viremia profile and serial changes of precore/core promoter sequences before and after HBeAg seroconversion in adult HBV carriers.
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• Liu CJ, Chen PJ, Lai MY, et al.: Viral factors correlate with hepatitis B e antigen seroconverson in patients with chronic hepatitis B. Liver Int 2006, 26:949-955. An important study showing the viremia profile and serial changes of precore/core promoter sequences before and after HBeAg seroconversion in adult HBV carriers.
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28
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34247478067
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• Andreani T, Serfaty L, Mohand D, et al.: Chronic hepatitis B virus carriers in the immunotolerant phase of infection: histologic findings and outcome. Clin Gastroenterol Hepatol 2007, 5:636-641. An important study confirming that adult HBV carriers in the immune tolerance phase have minimal histologic change and that liver biopsy is probably not necessary in this population.
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• Andreani T, Serfaty L, Mohand D, et al.: Chronic hepatitis B virus carriers in the immunotolerant phase of infection: histologic findings and outcome. Clin Gastroenterol Hepatol 2007, 5:636-641. An important study confirming that adult HBV carriers in the immune tolerance phase have minimal histologic change and that liver biopsy is probably not necessary in this population.
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•• Hui CK, Leung N, Yuen ST, et al.: Hong Kong Liver Fibrosis Study Group: Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology 2007, 46:395-401. The first study to demonstrate that disease progression in adult HBV carriers who remain in the immune tolerance phase is minimal.
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•• Hui CK, Leung N, Yuen ST, et al.: Hong Kong Liver Fibrosis Study Group: Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology 2007, 46:395-401. The first study to demonstrate that disease progression in adult HBV carriers who remain in the immune tolerance phase is minimal.
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30
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0036079898
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Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C
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Chu CJ, Hussain M, Lok AS: Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002, 122:1756-1762.
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Chu, C.J.1
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31
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Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers
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Kao JH, Chen PJ, Lai MY, Chen DS: Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol 2004, 72:363-369.
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• Yuen MF, Wong DK, Zheng BJ, et al.: Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion. J Viral Hepat 2007, 14:269-275. An interesting study showing that HBV genotype B and C patients have different T-helper cell responses in the immune clearance phase.
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• Yuen MF, Wong DK, Zheng BJ, et al.: Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion. J Viral Hepat 2007, 14:269-275. An interesting study showing that HBV genotype B and C patients have different T-helper cell responses in the immune clearance phase.
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33
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• Lin CL, Liao LY, Liu CJ, et al.: Hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum alanine aminotransferase levels. Hepatology 2007, 45:1193-1198. The first study to provide a biologic basis for the observation that HBV carriers with high-normal ALT levels at entry have a higher risk of disease progression than do those with low-normal ALT levels during follow-up.
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• Lin CL, Liao LY, Liu CJ, et al.: Hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum alanine aminotransferase levels. Hepatology 2007, 45:1193-1198. The first study to provide a biologic basis for the observation that HBV carriers with high-normal ALT levels at entry have a higher risk of disease progression than do those with low-normal ALT levels during follow-up.
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41
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HLA typing associated with hepatitis B e antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan
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