Endometrial structural and inflammatory changes with exogenous progestogens

Trends in Endocrinology and Metabolism

Volumn 19, Issue 5, 2008, Pages 167-174

  Hickey, Martha ^a   Salamonsen, Lois A ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMADINONE ACETATE; CYPROTERONE ACETATE; DEMEGESTONE; DESOGESTREL; DIENOGEST; DYDROGESTERONE; ELCOMETRINE; ETONOGESTREL; ETYNODIOL DIACETATE; GESTAGEN; GESTODENE; LEVONORGESTREL; LYNESTRENOL; MEDROGESTONE; MEGESTROL ACETATE; NANDROLONE; NANDROLONE DERIVATIVE; NOMEGESTROL ACETATE; NORETHISTERONE; NORETHISTERONE ACETATE; NORETYNODREL; NORGESTIMATE; NORGESTREL; PREGNANE DERIVATIVE; PROGESTERONE; PROGESTERONE DERIVATIVE; PROMEGESTONE; SPIRONOLACTONE; TRIMEGESTONE; UNINDEXED DRUG;

BLOOD CLOT; CELL SUBPOPULATION; CONTRACEPTION; DRUG MECHANISM; DRUG MEGADOSE; ENDOMETRIUM; GENE EXPRESSION; HEMOSTASIS; HUMAN; HYPOXIA; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; LOW DRUG DOSE; MENSTRUATION; MENSTRUATION DISORDER; MICROARRAY ANALYSIS; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; UTERUS BLEEDING;

ANTI-INFLAMMATORY AGENTS; CONTRACEPTIVE AGENTS, FEMALE; ENDOMETRITIS; ENDOMETRIUM; EPITHELIUM; FEMALE; HUMANS; PROGESTINS; UTERINE HEMORRHAGE;

EID: 45349086823     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2008.02.007     Document Type: Review

References (85)

1. Salamonsen L.A., and Jones R.L. Endometrial remodelling. In: Meyer J. (Ed). Encylopedia of Hormones (2003), Academic Press 504-512
2. Slayden O.D., and Brenner R.M. A critical period of progesterone withdrawal precedes menstruation in macaques. Reprod. Biol. Endocrinol. 4 (2006) S6
3. Giudice L.C. Application of functional genomics to primate endometrium: insights into biological processes. Reprod. Biol. Endocrinol. 4 (2006) S4
4. Catalano R.D., et al. Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol. Hum. Reprod. 13 (2007) 641-654
5. Christiaens G.C. Hemostasis in menstrual endometrium. Eur. J. Obstet. Gynecol. Reprod. Biol. 70 (1996) 19-20
6. Lockwood C.J., et al. Effects of thrombin on steroid-modulated cultured endometrial stromal cell fibrinolytic potential. J. Clin. Endocrinol. Metab. 81 (1996) 107-112
7. Salamonsen L.A., et al. Endometrial endothelin: regulator of uterine bleeding and endometrial repair. Clin. Exp. Pharmacol. Physiol. 26 (1999) 154-157
8. Ludwig H., and Spornitz U.M. Microarchitecture of the human endometrium by scanning electron microscopy: menstrual desquamation and remodeling. Ann. N. Y. Acad. Sci. 622 (1991) 28-46
9. Dignass A.U. Mechanisms and modulation of intestinal epithelial repair. Inflamm. Bowel Dis. 7 (2001) 68-77
10. Kaitu'u-Lino T.J., et al. Neutrophil depletion retards endometrial repair in a mouse model. Cell Tissue Res. 328 (2007) 197-206
11. Salamonsen L.A. The menstrual and estrous cycles. In: Aplin J., et al. (Ed). The Endometrium: Molecular, Cellular and Clinical Perspectives. 2nd edn (2006), Informa UK 25-45
12. Moore K.A., and Lemischka I.R. Stem cells and their niches. Science 311 (2006) 1880-1885
13. Shostak S. (Re)defining stem cells. Bioessays 28 (2006) 301-308
14. Li L., and Xie T. Stem cell niche: structure and function. Annu. Rev. Cell Dev. Biol. 21 (2005) 605-631
15. Gargett C.E. Uterine stem cells: what is the evidence?. Hum. Reprod. Update 13 (2007) 87-101
16. Hickey M., and Fraser I.S. A functional model for progestogen-induced breakthrough bleeding. Hum. Reprod. 15 (2000) 1-6
17. Hickey M., et al. Superficial endometrial vascular fragility in Norplant users and in women with ovulatory dysfunctional uterine bleeding. Hum. Reprod. 15 (2000) 1509-1514
18. Silverberg S.G., et al. Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Pathol. 5 (1986) 235-241
19. Marsh M.M., et al. Immunolocalization of endothelin and neutral endopeptidase in the endometrium of users of subdermally implanted levonorgestrel (Norplant). Hum. Reprod. 10 (1995) 2584-2589
20. Vincent A.J., et al. Endometrial breakdown in women using Norplant is associated with migratory cells expressing matrix metalloproteinase-9 (gelatinase B). Hum. Reprod. 14 (1999) 807-815
21. Critchley H.O., et al. Progestin receptor isoforms and prostaglandin dehydrogenase in the endometrium of women using a levonorgestrel-releasing intrauterine system. Hum. Reprod. 13 (1998) 1210-1217
22. Critchley H.O., et al. Immunohistochemical sex steroid receptor distribution in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle. Hum. Reprod. 8 (1993) 1632-1639
23. Macpherson A.M., et al. The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium. Hum. Reprod. 14 (1999) 3080-3087
24. Sereepapong W., et al. Endometrial progesterone and estrogen receptors and bleeding disturbances in depot medroxyprogesterone acetate users. Hum. Reprod. 19 (2004) 547-552
25. Bartelmez G.W. Menstruation. Physiol. Rev. 17 (1937) 28-72
26. Markee J.E. Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib. Embryol. 28 (1940) 219-308
27. Hourihan H.M., et al. A morphometric study of the effect of oral norethisterone or levonorgestrel on endometrial blood vessels. Contraception 34 (1986) 603-612
28. Hourihan H.M., et al. Endometrial vascular features prior to and following exposure to levonorgestrel. Contraception 43 (1991) 375-385
29. Johannisson E. Effects on the endometrium, endo- and exocervix following the use of local progestogen-releasing delivery systems. Contraception 42 (1990) 403-421
30. Song J.Y., et al. The effect of high-dose medium- and long- term progestogen exposure on endometrial vessels. Hum. Reprod. 10 (1995) 797-800
31. Guttinger A., and Critchley H.O. Endometrial effects of intrauterine levonorgestrel. Contraception 75 (2007) S93-S98
32. Hickey M., et al. Endometrial vasculature in Norplant users: preliminary results from a hysteroscopic study. Hum. Reprod. 11 (1996) 35-44
33. Hickey M., et al. Precise measurements of intrauterine vascular structures at hysteroscopy in menorrhagia and during Norplant use. Hum. Reprod. 13 (1998) 3190-3196
34. Lockwood C.J., et al. The role of tissue factor in regulating endometrial haemostasis: implications for progestin-only contraception. Hum. Reprod. 15 (2000) 144-151
35. Runic R., et al. Effects of norplant on endometrial tissue factor expression and blood vessel structure. J. Clin. Endocrinol. Metab. 85 (2000) 3853-3859
36. Stephanie R., et al. Endometrial vessel maturation in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time. Hum. Reprod. 22 (2007) 3084-3091
37. Hickey M., et al. A longitudinal study of changes in endometrial microvascular density in Norplant implant users. Contraception 59 (1999) 123-129
38. Rogers P.A., et al. Perivascular smooth muscle alpha-actin is reduced in the endometrium of women with progestin-only contraceptive breakthrough bleeding. Hum. Reprod. 15 (2000) 78-84
39. Ahluwalia A., et al. Modulation of uterine artery resistance to blood flow by the oral contraceptive pill. Adv. Contracept. 13 (1997) 47-54
40. Fraser I.S., et al. Endometrial blood flow measured by xenon 133 clearance in women with normal menstrual cycles and dysfunctional uterine bleeding. Am. J. Obstet. Gynecol. 156 (1987) 158-166
41. Hickey M., et al. The measurement of endometrial perfusion in norplant users: a pilot study. Hum. Reprod. 15 (2000) 1086-1091
42. Hickey M., et al. Long-term progestin-only contraceptives result in reduced endometrial blood flow and oxidative stress. J. Clin. Endocrinol. Metab. 91 (2006) 3633-3638
43. Ali M.H., et al. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. Am. J. Physiol. 277 (1999) L1057-L1065
44. Popovici R.M., et al. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J. Clin. Endocrinol. Metab. 84 (1999) 2245-2248
45. Sharkey A.M., et al. Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia. J. Clin. Endocrinol. Metab. 85 (2000) 402-409
46. Krikun G., et al. Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation. Biochem. Biophys. Res. Commun. 275 (2000) 159-163
47. Maisonpierre P.C., et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277 (1997) 55-60
48. Bulger E.M., and Maier R.V. Antioxidants in critical illness. Arch. Surg. 136 (2001) 1201-1207
49. Ondiveeran H.K., and Fox-Robichaud A. New developments in the treatment of ischemia/reperfusion injury. Curr. Opin. Investig. Drugs 2 (2001) 783-791
50. Krikun G., et al. Abnormal uterine bleeding during progestin-only contraception may result from free radical-induced alterations in angiopoietin expression. Am. J. Pathol. 161 (2002) 979-986
51. Moller B., et al. Expression of vascular endothelial growth factors and their receptors in human endometrium from women experiencing abnormal bleeding patterns after prolonged use of a levonorgestrel-releasing intrauterine system. Hum. Reprod. 20 (2005) 1410-1417
52. Roopa B.A., et al. The effect of a levonorgestrel-releasing intrauterine system on angiogenic growth factors in the endometrium. Hum. Reprod. 18 (2003) 1809-1819
53. Lockwood C.J., et al. Angiogenic factors and the endometrium following long term progestin only contraception. Histol. Histopathol. 19 (2004) 167-172
54. Jones R.L., et al. Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations. Hum. Reprod. 20 (2005) 2724-2735
55. Peloggia A., et al. Endometrial chemokines, uterine natural killer cells and mast cells in long-term users of the levonorgestrel-releasing intrauterine system. Hum. Reprod. 21 (2006) 1129-1134
56. Li R., et al. Doxycycline alters the expression of matrix metalloproteases in the endometrial cells exposed to ovarian steroids and pro-inflammatory cytokine. J. Reprod. Immunol. 73 (2007) 118-129
57. Hannan N.J., and Salamonsen L.A. Role of chemokines in the endometrium and in embryo implantation. Curr. Opin. Obstet. Gynecol. 19 (2007) 266-272
58. Bulmer J.N., et al. Leukocytes and resident blood cells in endometrium. Ann. N. Y. Acad. Sci. 622 (1991) 57-68
59. Song J.Y., et al. Effects of high dose progestogens on white cells and necrosis in human endometrium. Hum. Reprod. 11 (1996) 1713-1718
60. Clark D.A., et al. Endometrial lymphomyeloid cells in abnormal uterine bleeding due to levonorgestrel (Norplant). Hum. Reprod. 11 (1996) 1438-1444
61. Vincent A.J., and Salamonsen L.A. The role of matrix metalloproteinases and leukocytes in abnormal uterine bleeding associated with progestin-only contraceptives. Hum. Reprod. 15 (2000) 135-143
62. Morison N.B., et al. The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women. Reproduction 133 (2007) 309-321
63. Vincent A.J., et al. Matrix metalloproteinase-1 and -3 and mast cells are present in the endometrium of women using progestin-only contraceptives. Hum. Reprod. 15 (2000) 123-130
64. Salamonsen L.A., et al. Leukocyte networks and human endometrial remodelling. J. Reprod. Immunol. 57 (2002) 95-108
65. Zhang J., and Salamonsen L.A. In vivo evidence for active matrix metalloproteinases in human endometrium supports their role in tissue breakdown at menstruation. J. Clin. Endocrinol. Metab. 87 (2002) 2346-2351
66. Skinner J.L., et al. Regulation of matrix metalloproteinase-9 in endometrium during the menstrual cycle and following administration of intrauterine levonorgestrel. Hum. Reprod. 14 (1999) 793-799
67. Galant C., et al. Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding. Am. J. Pathol. 165 (2004) 83-94
68. Oliveira-Ribeiro M., et al. Correlation between endometrial histology, microvascular density and calibre, matrix metalloproteinase-3 and bleeding pattern in women using a levonorgestrel-releasing intrauterine system. Hum. Reprod. 19 (2004) 1778-1784
69. Galant C., et al. Temporal and spatial association of matrix metalloproteinases with focal endometrial breakdown and bleeding upon progestin-only contraception. J. Clin. Endocrinol. Metab. 85 (2000) 4827-4834
70. Abdel-Aleem, H. et al. (2007) Treatment of vaginal bleeding irregularities induced by progestin only contraceptives. Cochrane Database Syst. Rev. (4), CD003449
71. Archer D.F., et al. Management of irregular uterine bleeding and spotting associated with Norplant. Hum. Reprod. 11 Suppl. 2 (1996) 24-30
72. Kaewrudee S., et al. The effect of mefenamic acid on controlling irregular uterine bleeding secondary to Norplant use. Contraception 60 (1999) 25-30
73. Witjaksono J., et al. Oestrogen treatment for increased bleeding in Norplant users: preliminary results. Hum. Reprod. 11 Suppl. 2 (1996) 109-114
74. Glasier A.F., et al. Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant: a pilot study. Fertil. Steril. 77 (2002) 366-372
75. Cheng L., et al. Once a month administration of mifepristone improves bleeding patterns in women using subdermal contraceptive implants releasing levonorgestrel. Hum. Reprod. 15 (2000) 1969-1972
76. Jain J.K., et al. Mifepristone for the prevention of breakthrough bleeding in new starters of depo-medroxyprogesterone acetate. Steroids 68 (2003) 1115-1119
77. Massai M.R., et al. Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant implant users. Contraception 70 (2004) 47-54
78. Weisberg E., et al. A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon. Hum. Reprod. 21 (2006) 295-302
79. Kaitu'u T.J., et al. Matrix metalloproteinases in endometrial breakdown and repair: functional significance in a mouse model. Biol. Reprod. 73 (2005) 672-680
80. Li R., et al. Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: implication in irregular uterine bleeding. Hum. Reprod. 21 (2006) 2555-2563
81. Morison, N.B. et al. (2007) Mifepristone treatment halts Implanon-associated breakthrough bleeding by enhancing endometrial repair. In Proc. 38th Annual Conference of the Society for Reproductive Biology, 72
82. Cleland J., et al. Family planning: the unfinished agenda. Lancet 368 (2006) 1810-1827
83. Schindler A.E., et al. Classification and pharmacology of progestins. Maturitas 46 (2003) S7-S16
84. Elshafie M.A., and Ewies A.A. Transdermal natural progesterone cream for postmenopausal women: inconsistent data and complex pharmacokinetics. J. Obstet. Gynaecol. 27 (2007) 655-659
85. Salamonsen L.A. Tissue injury and repair in the female human reproductive tract. Reproduction 125 (2003) 301-311