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Volumn , Issue , 2008, Pages

Anticancer properties of PPARα - Effects on cellular metabolism and inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; BEZAFIBRATE; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN;

EID: 45249117703     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2008/930705     Document Type: Review
Times cited : (54)

References (87)
  • 1
    • 11444255268 scopus 로고
    • On respiratory impairment in cancer cells
    • Weinhouse S., Warburg O., Burk D., Schade A. L., On respiratory impairment in cancer cells Science 1956 124 3215 267 272
    • (1956) Science , vol.124 , Issue.3215 , pp. 267-272
    • Weinhouse, S.1    Warburg, O.2    Burk, D.3    Schade, A.L.4
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O., On the origin of cancer cells Science 1956 123 3191 309 314
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 3
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K., Mathew R., Beaudoin B., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 2006 10 1 51 64
    • (2006) Cancer Cell , vol.10 , Issue.1 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 5
    • 34447618831 scopus 로고    scopus 로고
    • PPARs and their metabolic modulation: New mechanisms for transcriptional regulation?
    • Ahmed W., Ziouzenkova O., Brown J., PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? Journal of Internal Medicine 2007 262 2 184 198
    • (2007) Journal of Internal Medicine , vol.262 , Issue.2 , pp. 184-198
    • Ahmed, W.1    Ziouzenkova, O.2    Brown, J.3
  • 6
    • 0036773047 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPAR α) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart
    • Finck B. N., Kelly D. P., Peroxisome proliferator-activated receptor α (PPAR α) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart Journal of Molecular and Cellular Cardiology 2002 34 10 1249 1257
    • (2002) Journal of Molecular and Cellular Cardiology , vol.34 , Issue.10 , pp. 1249-1257
    • Finck, B.N.1    Kelly, D.P.2
  • 7
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman B. M., Chen J., Evans R. M., Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δProceedings of the National Academy of Sciences of the United States of America 1997 94 9 4312 4317
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.9 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 9
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle P. J., Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years Diabetes/Metabolism Reviews 1998 14 4 263 283
    • (1998) Diabetes/Metabolism Reviews , vol.14 , Issue.4 , pp. 263-283
    • Randle, P.J.1
  • 11
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal β -oxidation and peroxisome proliferator-activated receptor α: aan adaptive metabolic system
    • Reddy J. K., Hashimoto T., Peroxisomal β -oxidation and peroxisome proliferator-activated receptor α: an adaptive metabolic system Annual Review of Nutrition 2001 21 193 230
    • (2001) Annual Review of Nutrition , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 13
    • 33745149291 scopus 로고    scopus 로고
    • P53 regulates mitochondrial respiration
    • Matoba S., Kang J.-G., Patino W. D., p53 regulates mitochondrial respiration Science 2006 312 5780 1650 1653
    • (2006) Science , vol.312 , Issue.5780 , pp. 1650-1653
    • Matoba, S.1    Kang, J.-G.2    Patino, W.D.3
  • 17
    • 0037459358 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) α and PPAR β / δ, but not PPAR γ, modulate the expression of genes involved in cardiac lipid metabolism
    • Gilde A. J., van der Lee K. A. J. M., Willemsen P. H. M., Peroxisome proliferator-activated receptor (PPAR) α and PPAR β / δ, but not PPAR γ, modulate the expression of genes involved in cardiac lipid metabolism Circulation Research 2003 92 5 518 524
    • (2003) Circulation Research , vol.92 , Issue.5 , pp. 518-524
    • Gilde, A.J.1    Van Der Lee, K.A.J.M.2    Willemsen, P.H.M.3
  • 19
    • 0035085845 scopus 로고    scopus 로고
    • Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor α in the adult rodent heart
    • Young M. E., Patil S., Ying J., Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor α in the adult rodent heart The FASEB Journal 2001 15 3 833 845
    • (2001) The FASEB Journal , vol.15 , Issue.3 , pp. 833-845
    • Young, M.E.1    Patil, S.2    Ying, J.3
  • 21
    • 2442485899 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 2 in THP1 monocytes inhibits β 2 integrin-mediated firm adhesion and transendothelial migration
    • Ryu J.-W., Hong K. H., Maeng J. H., Overexpression of uncoupling protein 2 in THP1 monocytes inhibits β 2 integrin-mediated firm adhesion and transendothelial migration Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 5 864 870
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.5 , pp. 864-870
    • Ryu, J.-W.1    Hong, K.H.2    Maeng, J.H.3
  • 22
    • 6044220129 scopus 로고    scopus 로고
    • Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor- α -regulated gene in cardiac and skeletal muscle
    • Stavinoha M. A., RaySpellicy J. W., Essop M. F., Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor- α -regulated gene in cardiac and skeletal muscle American Journal of Physiology 2004 287 5 E888 E895
    • (2004) American Journal of Physiology , vol.287 , Issue.5
    • Stavinoha, M.A.1    Rayspellicy, J.W.2    Essop, M.F.3
  • 28
    • 34547113520 scopus 로고    scopus 로고
    • Role of oxidative stress in cardiac dysfunction of PPAR α - // - Mice
    • Guellich A., Damy T., Lecarpentier Y., Role of oxidative stress in cardiac dysfunction of PPAR α-/-mice American Journal of Physiology 2007 293 1 H93 H102
    • (2007) American Journal of Physiology , vol.293 , Issue.1
    • Guellich, A.1    Damy, T.2    Lecarpentier, Y.3
  • 30
    • 0042429210 scopus 로고    scopus 로고
    • Fatty acid synthase expression defines distinct molecular signatures in prostate cancer
    • Rossi S., Graner E., Febbo P., Fatty acid synthase expression defines distinct molecular signatures in prostate cancer Molecular Cancer Research 2003 1 10 707 715
    • (2003) Molecular Cancer Research , vol.1 , Issue.10 , pp. 707-715
    • Rossi, S.1    Graner, E.2    Febbo, P.3
  • 33
    • 0034650757 scopus 로고    scopus 로고
    • Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer E. S., Thupari J., Han W. F., Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Research 2000 60 2 213 218
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3
  • 43
    • 0028113617 scopus 로고
    • Epidemiology of colorectal cancer revisited: Are serum triglycerides and/or plasma glucose associated with risk?
    • McKeown-Eyssen G., Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiology Biomarkers & Prevention 1994 3 8 687 695
    • (1994) Cancer Epidemiology Biomarkers & Prevention , vol.3 , Issue.8 , pp. 687-695
    • McKeown-Eyssen, G.1
  • 45
    • 20544449673 scopus 로고    scopus 로고
    • The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β -oxidation
    • Buzzai M., Bauer D. E., Jones R. G., The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β -oxidation Oncogene 2005 24 26 4165 4173
    • (2005) Oncogene , vol.24 , Issue.26 , pp. 4165-4173
    • Buzzai, M.1    Bauer, D.E.2    Jones, R.G.3
  • 46
    • 20844449238 scopus 로고    scopus 로고
    • AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    • Jones R. G., Plas D. R., Kubek S., AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Molecular Cell 2005 18 3 283 293
    • (2005) Molecular Cell , vol.18 , Issue.3 , pp. 283-293
    • Jones, R.G.1    Plas, D.R.2    Kubek, S.3
  • 47
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • Buzzai M., Jones R. G., Amaravadi R. K., Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth Cancer Research 2007 67 14 6745 6752
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 48
    • 29244436681 scopus 로고    scopus 로고
    • AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPAR α and PGC-1
    • Lee W. J., Kim M., Park H.-S., AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPAR α and PGC-1 Biochemical and Biophysical Research Communications 2006 340 1 291 295
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.1 , pp. 291-295
    • Lee, W.J.1    Kim, M.2    Park, H.-S.3
  • 50
    • 2542561169 scopus 로고    scopus 로고
    • Akt stimulates aerobic glycolysis in cancer cells
    • Elstrom R. L., Bauer D. E., Buzzai M., Akt stimulates aerobic glycolysis in cancer cells Cancer Research 2004 64 11 3892 3899
    • (2004) Cancer Research , vol.64 , Issue.11 , pp. 3892-3899
    • Elstrom, R.L.1    Bauer, D.E.2    Buzzai, M.3
  • 53
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A., Zwartkruis F. J. T., Nobukuni T., Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 Molecular Cell 2003 11 6 1457 1466
    • (2003) Molecular Cell , vol.11 , Issue.6 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.T.2    Nobukuni, T.3
  • 62
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X., Yu J., Bhagat G., Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene Journal of Clinical Investigation 2003 112 12 1809 1820
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 64
    • 33947495259 scopus 로고    scopus 로고
    • Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
    • Iwamaru A., Kondo Y., Iwado E., Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells Oncogene 2007 26 13 1840 1851
    • (2007) Oncogene , vol.26 , Issue.13 , pp. 1840-1851
    • Iwamaru, A.1    Kondo, Y.2    Iwado, E.3
  • 66
    • 37549005069 scopus 로고    scopus 로고
    • Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin
    • Jin Q., Feng L., Behrens C., Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin Cancer Research 2007 67 24 11630 11639
    • (2007) Cancer Research , vol.67 , Issue.24 , pp. 11630-11639
    • Jin, Q.1    Feng, L.2    Behrens, C.3
  • 71
    • 0032565868 scopus 로고    scopus 로고
    • Activation of human aortic smooth-muscle cells is inhibited by PPAR α but not by PPAR γ activators
    • Staels B., Koenig W., Habib A., Activation of human aortic smooth-muscle cells is inhibited by PPAR α but not by PPAR γ activators Nature 1998 393 6687 790 793
    • (1998) Nature , vol.393 , Issue.6687 , pp. 790-793
    • Staels, B.1    Koenig, W.2    Habib, A.3
  • 81
    • 34250333058 scopus 로고    scopus 로고
    • NF- κ B inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia
    • Fabre C., Carvalho G., Tasdemir E., NF- κ B inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia Oncogene 2007 26 28 4071 4083
    • (2007) Oncogene , vol.26 , Issue.28 , pp. 4071-4083
    • Fabre, C.1    Carvalho, G.2    Tasdemir, E.3
  • 85
    • 38549095046 scopus 로고    scopus 로고
    • PPAR α deficiency in inflammatory cells suppresses tumor growth
    • Kaipainen A., Kieran M. W., Huang S., PPAR α deficiency in inflammatory cells suppresses tumor growth PLoS ONE 2007 2 2 e260
    • (2007) PLoS ONE , vol.2 , Issue.2 , pp. 260
    • Kaipainen, A.1    Kieran, M.W.2    Huang, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.