Definitive endoderm: A key step in coaxing human embryonic stem cells into transplantable β-cells

Biochemical Society Transactions

Volumn 36, Issue 3, 2008, Pages 272-275

  Semb, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

cell; Cell therapy; Definitive endoderm; Human embryonic stem cell; Islet transplantation; Pancreatic development

Indexed keywords

CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL THERAPY; CELL TRANSPLANTATION; CELL TYPE; CONFERENCE PAPER; EMBRYONIC STEM CELL; ENDODERM; FETUS DEVELOPMENT; GASTROINTESTINAL TRACT; HUMAN; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MESODERM; NONHUMAN; ONTOGENY; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTIVINS; ANIMALS; EMBRYONIC STEM CELLS; ENDODERM; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 45249096927     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360272     Document Type: Conference Paper

References (26)

1. Shapiro, A.M., Lakey, J.R., Ryan, E.A., Korbutt, G.S., Toth, E., Warnock, G.L., Kneteman, N.M. and Rajotte, R.V. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 27, 230-238
2. Grapin-Botton, A. and Constam, D. (2007) Evolution of the mechanisms and molecular control of endoderm formation. Mech. Dev. 124, 253-278
3. Zorn, A.M. and Wells, J.M. (2007) Molecular basis of vertebrate endoderm development. Int. Rev. Cytol. 259, 49-111
4. Kubo, A., Shinozaki, K., Shannon, J.M., Kouskoff, V., Kennedy, M., Woo, S., Fehling, H.J. and Keller, G. (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131, 1651-1662
5. Dyson, S. and Gurdon, J.B. (1998) The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93, 557-568
6. Gurdon, J.B., Harger, P., Mitchell, A. and Lemaire, P. (1994) Activin signalling and response to a morphogen gradient. Nature 371, 487-492
7. Latinkic, B.V., Umbhauer, M., Neal, K.A., Lerchner, W., Smith, J.C. and Cunliffe, V. (1997) The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev. 11, 3265-3276
8. Wilson, P.A. and Melton, O.A. (1994) Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4, 676-686
9. Gadue, P., Huber, T.L., Paddison, P.J. and Keller, G.M. (2006) Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103, 16806-16811
10. Tada, S., Era, T., Furusawa, C., Sakurai, H., Nishikawa, S., Kinoshita, M., Nakao, K., Chiba, T. and Nishikawa, S. (2005) Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 132, 4363-4374
11. Yasunaga, M., Tada, S., Torikai-Nishikawa, S., Nakano, Y., Okada, M., Jakt, L.M., Nishikawa, S., Chiba, T., Era, T. and Nishikawa, S. (2005) Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat. Biotechnol. 23, 1542-1550
12. D'Amour, K.A., Agulnick, A.D., Eliazer, S., Kelly, O.G., Kroon, E. and Baetge, E.E. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23, 1534-1541
13. D'Amour, K.A., Bang, A.G., Eliazer, S., Kelly, O.G., Agulnick, A.D., Smart, N.G., Moorman, M.A., Kroon, E., Carpenter, M.K. and Baetge, E.E. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24, 1392-1401
14. Gouon-Evans, V., Boussemart, L., Gadue, P., Nierhoff, D., Koehler, C.I., Kubo, A., Shafritz, D.A. and Keller, G. (2006) BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat. Biotechnol. 24, 1402-1411
15. Loebel, D.A. and Tam, P.P. (2005) A gut feeling. Nat. Biotechnol. 23, 1491-1492
16. Shen, M.M. (2007) Nodal signaling: developmental roles and regulation. Development 134, 1023-1034
17. Besser, D. (2004) Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. J. Biol. Chem. 279, 45076-45084
18. Chen, C. and Shen, M.M. (2004) Two modes by which Lefty proteins inhibit nodal signaling. Curr. Biol. 14, 618-624
19. Cheng, S.K., Olale, F., Brivanlou, A.H. and Schier, A.F. (2004) Lefty blocks a subset of TGFβ signals by antagonizing EGF-CFC coreceptors. PLoS Biol. 2, E30
20. Branford, W.W. and Yost, H.J. (2002) Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation. Curr. Biol. 12, 2136-2141
21. Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W. and Stemple, D.L. (2002) Lefty antagonism of Squint is essential for normal gastrulation. Curr. Biol. 12, 2129-2135
22. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J. et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298
23. Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E.M. (1999) The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710
24. Silva, A.C., Filipe, M., Kuerner, K.M., Steinbeisser, H. and Belo, J.A. (2003) Endogenous Cerberus activity is required for anterior head specification in Xenopus. Development 130, 4943-4953
25. Marques, S., Borges, A.C., Silva, A.C., Freitas, S., Cordenonsi, M. and Belo, J.A. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 18, 2342-2347
26. Perea-Gomez, A., Vella, F.D., Shawlot, W., Oulad-Abdelghani, M., Chazaud, C., Meno, C., Pfister, V., Chen, L., Robertson, E., Hamada, H. et al. (2002) Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev. Cell 3, 745-756