Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation

Current Biology

Volumn 12, Issue 24, 2002, Pages 2136-2141

  Branford, William W ^a   Yost, H Joseph ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ANTISENSE OLIGONUCLEOTIDE; CERBERUS PROTEIN, XENOPUS; GOOSECOID PROTEIN; HOMEODOMAIN PROTEIN; LEFT RIGHT DETERMINATION FACTOR PROTEINS; LEFT-RIGHT DETERMINATION FACTOR PROTEINS; NDR2 PROTEIN, VERTEBRATE; NDR2 PROTEIN, XENOPUS; ONCOPROTEIN; PROTEIN; PROTEIN NODAL; REPRESSOR PROTEIN; SIGNAL PEPTIDE; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; XBRA PROTEIN, XENOPUS; XENOPUS PROTEIN; XNR3 PROTEIN, XENOPUS; ZEBRAFISH PROTEIN;

ANIMAL; ANIMAL EMBRYO; ARTICLE; DRUG EFFECT; EMBRYONIC STRUCTURES; GASTRULA; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; XENOPUS;

ACTIVINS; ANIMALS; EMBRYO, NONMAMMALIAN; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GOOSECOID PROTEIN; HOMEODOMAIN PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESODERM; OLIGONUCLEOTIDES, ANTISENSE; ORGANIZERS, EMBRYONIC; PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS; XENOPUS; XENOPUS PROTEINS; ZEBRAFISH PROTEINS;

ANIMALIA; CERBERUS; EUKARYOTA; VERTEBRATA;

EID: 0037164735     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01360-X     Document Type: Article

References (30)

1. Chen, Y., and Schier, A.F. (2001). The zebrafish Nodal signal Squint functions as a morphogen. Nature 411, 607-610.
2. Bisgrove, B.W., Essner, J.J., and Yost, H.J. (1999). Regulation of midline development by antagonism of lefty and nodal signaling. Development 126, 3253-3262.
3. Cheng, A.M., Thisse, B., Thisse, C., and Wright, C.V. (2000). The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in Xenopus. Development 127, 1049-1061.
4. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J., et al. (1999). Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298.
5. Branford, W.W., Essner, J.J., and Yost, H.J. (2000). Regulation of gut and heart left-right asymmetry by context-dependent interactions between Xenopus lefty and BMP4 signaling. Dev. Biol. 223, 291-306.
6. Jones, C.M., Kuehn, M.R., Hogan, B.L., Smith, J.C., and Wright, C.V. (1995). Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 3651-3662.
7. Aoki, T.O., Mathieu, J., Saint-Etienne, L., Rebagliati, M.R., Peyrieras, N., and Rosa, F.M. (2002). Regulation of nodal signaling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor. Dev. Biol. 241, 273-288.
8. Lustig, K.D., Kroll, K., Sun, E., Ramos, R., Elmendorf, H., and Kirschner, M.W. (1996). A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. Development 122, 3275-3282.
9. Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. (1998). Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev. Biol. 199, 261-272.
10. Takahashi, S., Yokota, C., Takano, K., Tanegashima, K., Onuma, Y., Goto, J., and Asashima, M. (2000). Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center. Development 127, 5319-5329.
11. Toyama, R., O'Connell, M.L., Wright, C.V., Kuehn, M.R., and Dawid, I.B. (1995). Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development 121, 383-391.
12. Keller, R.E., Danilchik, M., Gimlich, R., and Shih, J. (1985). The function and mechanism of convergent extension during gastrulation of Xenopus laevis. J. Embryol. Exp. Morphol. Suppl. 89, 185-209.
13. Keller, R., and Danilchik, M. (1988). Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis. Development 103, 193-209.
14. Onuma, Y., Takahashi, S., Yokota, C., and Asashima, M. (2002). Multiple nodal-related genes act coordinately in Xenopus embryogenesis. Dev. Biol. 241, 94-105.
15. Cho, K.W., Blumberg, B., Steinbeisser, H., and De Robertis, E.M. (1991). Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.
16. Kurth, T., and Hausen, P. (2000). Bottle cell formation in relation to mesodermal patterning in the Xenopus embryo. Mech. Dev. 97, 117-131.
17. Laurent, M.N., Blitz, I.L., Hashimoto, C., Rothbacher, U., and Cho, K.W. (1997). The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Development 124, 4905-4916.
18. Watabe, T., Kim, S., Candia, A., Rothbacher, U., Hashimoto, C., Inoue, K., and Cho, K.W. (1995). Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9, 3038-3050.
19. Smith, W.C., McKendry, R., Ribisi, S., Jr., and Harland, R.M. (1995). A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82, 37-46.
20. McKendry, R., Hsu, S.C., Harland, R.M., and Grosschedl, R. (1997). LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Dev. Biol. 192, 420-431.
21. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B., and De Robertis, E.M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
22. Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T., and De Robertis, E.M. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.
23. Artinger, M., Blitz, I., Inoue, K., Tran, U., and Cho, K.W. (1997). Interaction of goosecoid and brachyury in Xenopus mesoderm patterning. Mech. Dev. 65, 187-196.
24. Smith, J.C., Price, B.M., Green, J.B., Weigel, D., and Herrmann, B.G. (1991). Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79-87.
25. Joseph, E.M., and Melton, D.A. (1997). Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer. Dev. Biol. 184, 367-372.
26. Sasai, Y., Lu, B., Piccolo, S., and De Robertis, E.M. (1996). Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J. 15, 4547-4555.
27. Christian, J.L., McMahon, J.A., McMahon, A.P., and Moon, R.T. (1991). Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development 111, 1045-1055.
28. Tanegashima, K., Yokota, C., Takahashi, S., and Asashima, M. (2000). Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction. Mech. Dev. 99, 3-14.
29. Vodicka, M.A., and Gerhart, J.C. (1995). Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis. Development 121, 3505-3518.
30. Winklbauer, R., and Schurfeld, M. (1999). Vegetal rotation, a new gastrulation movement involved in the internalization of the mesoderm and endoderm in Xenopus. Development 126, 3703-3713.