Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects

Chest

Volumn 110, Issue 1, 1996, Pages 263-270

  Jagielo, Paul J ^a   Thorne, Peter S ^a   Watt, Janet L ^a   Frees, Kathy L ^a   Quinn, Timothy J ^a   Schwartz, David A ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

airflow obstruction; airway inflammation; endotoxin; grain dust; inhalation

Indexed keywords

CYTOKINE; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; COUGHING; DYSPNEA; FORCED EXPIRATORY VOLUME; GRAIN DUST; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; LUNG LAVAGE; NORMAL HUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SPUTUM; SYMPTOMATOLOGY;

EID: 0029977853     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.110.1.263     Document Type: Article

References (33)

1. doPico GA, Reddan W, Flaherty D, et al. Respiratory abnormalities among grain handlers: a clinical, physiologic, and immunologic study. Am Rev Respir Dis 1977; 115:915-27
2. Chan-Yeung M, Schulzer M, MacLean L, et al. Epidemiologic health survey of grain elevator workers in British Columbia. Am Rev Respir Dis 1980; 121:329-38
3. Dosman JA, Cotton DJ, Graham BL, et al. Chronic bronchitis and decreased forced expiratory flow rates in lifetime nonsmoking, grain workers. Am Rev Respir Dis 1980; 121:11-6
4. Chan-Yeung M, Schulzer M, MacLean L, et al. A follow-up study of the grain elevator workers in the port of Vancouver. Arch Environ Health 1981; 36:75-81
5. doPico GA, Reddan W, Anderson S, et al. Acute effects of grain dust exposure during a work shift. Am Rev Respir Dis 1983; 128:399-404
6. doPico GA, Reddan W, Tsiatis A, et al. Epidemiologic study of clinical and physiologic parameters in grain handlers of northern United States. Am Rev Respir Dis 1984; 130:759-65
7. Mink JT, Gerrard JW, Cockcroft DW, et al. Increased bronchial reactivity to inhaled histamine in nonsmoking grain workers with normal lung function. Chest 1980; 77:28-31
8. Huy T, Schipper KD, Chan-Yeung M, et al. Grain dust and lung function: dose-response relationships. Am Rev Respir Dis 1991; 144:1314-21
9. 1 in grain handlers. Am Rev Respir Dis 1985; 132:814-17
10. Clapp WD, Becker S, Quay J, et al. Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract. Am J Respir Crit Care Med 1994; 150:611-17
11. DeLucca AJ II, Godshall MA, Palmgren MS. Gram-negative bacterial endotoxins in grain elevator dusts. Am Ind Hyg Assoc J 1984; 45:336-39
12. Rylander R, Bake BK, Fischer JJ, et al. Pulmonary function and symptoms after inhalation of endotoxin. Am Rev Respir Dis 1989; 140:981-86
13. Michel O, Ginanni R, Bon BL, et al. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 1992; 146:352-57
14. Schmidt LE, Thorne PS, Watt JL, et al. Is an abbreviated bronchial challenge with histamine valid? Chest 1992; 101: 141-45
15. Chai H, Farr RS, Froehlich LA, et al. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975; 56:323-27
16. Clapp WD, Thorne PS, Frees KL, et al. The acute effects of inhalation of grain dust extract and endotoxin on upper and lower airways. Chest 1993; 104:825-30
17. Lundholm M, Palmgren U, Malmberg P. Exposure to endotoxin in the farm environment. Am J Ind Med 1986; 10:314-15
18. Rask-Andersen A, Malmberg P, Lundholm M. Endotoxin levels in farming: absence of symptoms despite high exposure levels. Br J Ind Med 1989; 46:412-16
19. American Thoracic Society Statement. Snowbird workshop on standardization of spirometry. Am Rev Respir Dis 1979; 119:831-38
20. American Thoracic Society. Statement: summary and recommendations of a workshop on the investigative use of bronchoscopy and bronchoalveolar lavage in asthmatics. Am Rev Respir Dis 1985; 132:180-82
21. Leeper-Woodford SK, Carey PD, Byrne K, et al. Tumor necrosis factor: alpha and beta subunits appear in circulation during onset of sepsis-induced lung injury. Am Rev Respir Dis 1991; 143:1076-82
22. Brenner CA, Tain AW, Neslon PA, et al. Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNA's from small numbers of cells. Biotechniques 1989; 7:1096-1100
23. Ponte P, Ng SY, Engel J, et al. Evolutionary conservation in the untranslated regions of the actin mRNAs: DNA sequence of the human beta-actin cDNA. Nucleic Acids Res 1984; 12:1684-96
24. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86:9717-21
25. Matsushima K, Morishita K, Yoshimura T, et al. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin-1 and tumor necrosis factor. J Exp Med 1988; 167: 1883-93
26. Rosner B. Fundamentals of biostatistics. 3rd ed. Boston: PWS-Kent Publishing, 1990
27. Schwartz DA, Thorne PS, Jagielo PJ, et al. Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract. Am J Physiol 1994; 267:L609-17
28. Jakab CJ, Hmieleski RR, Zarba A, et al. Respiratory aflatoxicosis: suppression of pulmonary and systemic host defenses in rats and mice. Toxicol Appl Pharmacol 1994; 125:198-205
29. Skea DL, McAvoy D, Broder I. Grain dust contains a tannin-like material which fixes complement. Environ Res 1988; 46:181-89
30. Olenchock SA, Lewis DM, Mull JC. Composition of extracts of airborne grain dusts: lectins and lymphocyte mitogens. Environ Health Perspect 1986; 66:119-23
31. Fogelmark B, Sjostrand M, Rylander R. Pulmonary inflammation induced by repeated inhalations of β(1,3)-D-glucan and endotoxin. Int J Exp Pathol 1994; 75:85-90
32. Schwartz DA, Thorne PS, Yagla SJ, et al. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med 1995; 152:603-08
33. Jagielo PJ, Thorne PS, Kern JA, et al. The role of endotoxin in grain dust induced lung inflammation in mice. Am J Physiol 1996 (in press)