Advances in studies on antiviral activities of flavonoids

Chinese Traditional and Herbal Drugs

Volumn 39, Issue 4, 2008, Pages 623-627

  Gong, Jin Yan ^a   Zhang, Ying ^a   Wu, Xiao Qin ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Antiviral activities; Flavonoids; Pharmacological effect

Indexed keywords

AGATHISFLAVONE; ALKANNA ORIENTALIS EXTRACT; AMENTOFLAVONE; ANTIVIRUS AGENT; CARDAMONIN; ERMANIN; FLAVONE DERIVATIVE; FLAVONOID; GARCINIA MULTIFLORA EXTRACT; GLABRANIN; HINOKIFLAVONE; INTEGRASE INHIBITOR; ISOKAEMPFERIDE; JACEIDIN; KAEMPFEROL 3 RHAMNOSIDE; LEACHIANONE G; MORALBANONE; MORELLOFLAVONE; PENDULETIN; PINOSTROBIN; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; RHUS SUCCEDANEA EXTRACT; ROBUSTAFLAVONE; SAMARANGENIN B; THALASSIOLIN A; THALASSIOLIN B; THALASSIOLIN C3; THEVATIA PERUVIANA EXTRACT; UNINDEXED DRUG;

ALKANNA ORIENTALIS; ANTIVIRAL ACTIVITY; CONTROLLED STUDY; DRUG STRUCTURE; GARCINIA; GARCINIA MULTIFLORA; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 1; MEDICINAL PLANT; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; RHUS SUCCEDANEA; STRUCTURE ACTIVITY RELATION; THEVATIA PERUVIANA;

EID: 45149133477     PISSN: 02532670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Chinese source.
2. Chinese source.
3. Chinese source.
4. Chinese source.
5. Reutrakul V, Krachannchaenn C, Tuchinda P. Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera [J]. Tetrahedon, 2004, 60 (7): 1517-1523.
6. Chinese source.
7. Tewtrakul S, Nakamura N, Hattori M, et al. Flavanone and flavonol glycosides from the leaves of Thevetia peruviana and their HIV-1 reverse transcriptase and HIV-1 integrase inhibitory activities [J]. Chem Pharm Bull, 2002, 50 (5): 630-635.
8. Lin Y M, Anderson H, Flavin M T, et al. In vitro and-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora [J]. J Nat Prod, 1997, 60 (9): 884-888.
9. Lee J S, Kim H J, Lee Y S. A new anti-HIV flavonoid from glucoronide from Chrysanthemum morifolium [J]. Planta Med, 2003, 69(9): 859-861.
10. Rowley D C, Hansen M S T, Rhodes D, et al. Thalassiolins A - C: new marine-derived inhibitors of HIV cDNA integrase [J]. Bioorg Med Chem, 2002, 10: 3619-3625.
11. Chinese source.
12. Kim H J, Woo E R, Shin C G, et al. A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase [J]. J Nat Prod, 1998, 61(1): 145-148.
13. Li B Q, Fu T, Yan Y D, et al. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry [J]. Biochem Biophys Res Commun, 2000, 276(2): 534-538.
14. Cushnie T P T, Lamb A J. Antimicrobial activity of flavonoids [J]. Int J Antimicorb AG, 2005, 26 (5): 343-356.
15. Chinese source.
16. Chinese source.
17. Li Y L, Ma S C, Yang Y T, et al. Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge [J]. J Ethnopharm, 2002, 79(3): 365-368.
18. Chinese source.
19. Lin Y M, Flavin M T, Schure R, et al. Antiviral activities of biflavonoids [J]. Planta Med, 1999, 65(2): 120-125.
20. Cai S Q, Wang R F, Yang X W, et al. Antiviral flavonoid-type C-glycosides from the flowers of Trollius chinensis [J]. Chem Biodivers, 2006, 3(3): 343-348.
21. Chinese source.
22. ElSohly H N, ElFeraly F S, Joshi A S. Antiviral flavonoids from Alkanna orientalis [J]. Planta Med, 1997, 63 (4): 384.
23. Tait S, Salvati A L, Desideri N. Antiviral activity of substituted homoisoflavonoids on enteroviruses 3 [J]. Antivir Res, 2006, 72: 252-255.
24. Chinese source.
25. Chinese source.
26. de Almeida A R, Miranda M M F S, Simoni I C, et al. Flavonol monoglycosides isolated from the antiviral fractions of Persea Americana (Lauraceae) leaf infusion [J]. Phytother Res, 1998, 12(8): 562-567.
27. Amaral A C F, Kuster R M, Gongalves J L S. Antiviral investigation of the flavonoids of Chamaesyce thymifolia [J]. Fitoterapia, 1999, 70: 293-295.
28. Chiang L C, Chiang W, Liu M C, et al. In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids [J]. J Antimicrob Chemother, 2003, 52(2): 194-198.
29. Chinese source.
30. Du J, He Z D, Jiang R W, et al. Antiviral flavonoids from the root bark of Morus alba L. [J]. Phytochemistry, 2003, 62(8): 1235-1238.
31. Chinese source.
32. Chinese source.
33. Lyu S Y, Rhim J Y, Park W B. Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro [J]. Arch Pharm Res, 2005, 28 (11): 1293-1301.
34. Lin L C, Kuo Y C, Chou C J. Anti-herpes simplex virus type-1 flavonoids and a new flavanone from the root of Limonium sinense [J]. Planta Med, 2000, 66(4): 333-336.
35. Chinese source.
36. Ma S C, But P P H, Ooi V E C, et al. Antiviral amentoflavone from Selaginella sinensis [J]. Biol Pharm Bull, 2001, 24(3): 311-312.
37. Ma S C, Du J, But P P H, et al. Anriviral Chinese medicinal herbs against respiratory syncytial virus [J]. J Ethnopharmacol, 2002, 79(2): 205-211.
38. Chinese source.
39. Wei F, Ma S C, Ma L Y, et al. Antiviral flavonoids from the seeds of Aesculus chinensis [J]. J Nat Prod, 2004, 67 (4): 650-653.
40. Lin Y M, Zembower D E, Flavin M T. Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro [J]. Bioorg Med Chem Lett, 1997, 7(17): 2325-2328.
41. Huang R L, Chen C C, Huang H L, et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis [J]. Planta Med, 2000, 66(8): 694-698.
42. Sanchez I, Gomez-Garibay F, Taboada J, et al. Antiviral effect of flavonoids on the dengue virus [J]. Phytother Res, 2000, 14(2): 89-92.
43. Kiat T S, Pippen R, Yusof R, et al. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of finger-root, Boesengergia rotunda (L.) towards dengus-2 virus NS3 protease [J]. Bioorg Med Chem Lett, 2006, 16(12): 3337-3340.
44. Peiris J S, Chu C M, Cheng V C, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study [J]. Lancet, 2003, 361(9371): 1767-1772.
45. Semple, S, Nobbs S F, Pyke S M, et al. Antiviral flavonoid from Pterocaulon sphacelatum, an Australian aboriginal medicine [J]. J Ethnopharmacol, 1999, 68(1-3): 283-288.
46. Naira M P N, Kandaswamib C, Mahajana S, et al. The flavonoid, quercetin, differentially regulates Th-1 (INFγ) and Th-2 (IL-4) cytokine gene expression by normal peripheral blood mononuclear cells [J]. Bba-Mol Cell Res, 2002, 1593(1): 29-36.
47. Lee W J, Shim J Y, Zhu B T. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids [J]. Mol Pharmacol, 2005, 68(4): 1018-1030.
48. Evers D L, Chao C F, Wang X, et al. Human cytomegalovirus-inhibitory flavonoids: Studies on antiviral activity and mechanism of action [J]. Antivir Res, 2005, 68: 124-134.
49. Chinese source.