The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss

Neuropsychopharmacology

Volumn 33, Issue 8, 2008, Pages 1980-1991

  Bardgett, Mark E ^a   Points, Megan ^a   Ramsey Faulkner, Christian ^a   Topmiller, Jeff ^a   Roflow, John ^a   McDaniel, Travis ^a   Lamontagne, Timberly ^a   Griffith, Molly S ^a  

^a NORTHERN KENTUCKY UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Hippocampus; NMDA; Norepinephrine; Schizophrenia; Spatial memory

Indexed keywords

CLONIDINE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; SODIUM CHLORIDE;

ACCURACY; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARM; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; EXCITOTOXICITY; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TASK PERFORMANCE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ATTENTION; CLONIDINE; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; N-METHYLASPARTATE; PSYCHOMOTOR PERFORMANCE; RATS; RATS, LONG-EVANS; REINFORCEMENT SCHEDULE; SPACE PERCEPTION;

EID: 45149118508     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301580     Document Type: Article

References (63)

1. Acquas E, Wilson C, Fibiger HC (1998). Pharmacology of sensory stimulation-evoked increases in frontal cortical acetylcholine release. Neuroscience 85: 73-83.
2. Adams B, Moghaddam B (1998). Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J Neurosci 18: 5545-5554.
3. Ammassari-Teule M, Maho C, Sara SJ (1991). Clonidine reverses spatial learning deficits and reinstates theta frequencies in rats with partial fornix section. Behav Brain Res 45: 1-8.
4. Arnsten AF (2004). Adrenergic targets for the treatment of cognitive deficits in schizophrenia. Psychopharmacology 174: 25-31.
5. Arnsten AF, Goldman-Rakic PS (1985). Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230: 1273-1276.
6. Arnsten AF, Goldman-Rakic PS (1990). Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging 11: 583-590.
7. Aultman JM, Moghaddam B (2001). Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task. Psychopharmacology 153: 353-364.
8. Aura J, Riekkinen Jr P (1999). Blockade of NMDA receptors located at the dorsomedial prefrontal cortex impairs spatial working memory in rats. Neuroreport 10: 243-248.
9. Bardgett ME, Baum KT, O'Connell SM, Lee NM, Hon JC (2006a). Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage. Neuropharmacology 51: 1156-1162.
10. Bardgett ME, Boeckman R, Krochmal D, Fernando H, Ahrens R, Csernansky JG (2003). NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice. Brain Res Bull 60: 131-142.
11. Bardgett ME, Griffith MS, Foltz RF, Hopkins JA, Massie CM, O'Connell SM (2006b). The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage. Neurobiol Learn Mem 85: 86-94.
12. Bernaerts P, Lamberty Y, Tirelli E (2004). Histamine H3 antagonist thioperamide dose-dependently enhances memory consolidation and reverses amnesia induced by dizocilpine or scopolamine in a one-trial inhibitory avoidance task in mice. Behav Brain Res 154: 211-219.
13. Boehm S (1999). Presynaptic alpha2-adrenoceptors control excitatory, but not inhibitory, transmission at rat hippocampal synapses. J Physiol 519: 439-449.
14. Csernansky JG, Csernansky CA, Kogelman L, Montgomery EM, Bardgett ME (1998). Progressive neurodegeneration after intracerebroventricular kainic acid administration in rats: implications for schizophrenia? Biol Psychiatry 44: 1143-1150.
15. Csernansky JG, Martin M, Shah R, Bertchume A, Colvin J, Dong H (2005). Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology 30: 2135-2143.
16. Csernansky JG, Wang L, Joshi S, Miller JP, Gado M, Kido D et al (2000). Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type. Neurology 55: 1636-1643.
17. Dudchenko PA (2001). How do animals actually solve the T maze? Behav Neurosci 115: 850-860.
18. Floresco SB, Geyer MA, Gold LH, Grace AA (2005). Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia. Schizophr Bull 31: 888-894.
19. Franowicz JS, Arnsten AF (2002). Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype. Psychopharmacology 162: 304-312.
20. Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF (2002). Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22: 8771-8777.
21. Friedman JI, Adler DN, Temporini HD, Kemether E, Harvey PD, White L et al (2001). Guanfacine treatment of cognitive impairment in schizophrenia. Neuropsychopharmacology 25: 402-409.
22. Green MF, Olivier B, Crawley JN, Penn DL, Silverstein S (2005). Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conference. Schizophr Bull 31: 882-887.
23. Grundman M, Sencakova D, Jack Jr CR, Petersen RC, Kim HT, Schultz A et al (2002). Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial. J Mol Neurosci 19: 23-27.
24. Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI et al (2000). Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry 57: 769-775.
25. Heckers S (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 11: 520-528.
26. Hyman SE, Fenton WS (2003). What are the right targets for psychopharmacology? Science 299: 350-351.
27. Isaac JT, Ashby M, McBain CJ (2007). The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron 54: 859-871.
28. Jackson ME, Homayoun H, Moghaddam B (2004). NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proc Natl Acad Sci 101: 8467-8472.
29. Jacobs PS, Taylor BM, Bardgett ME (2000). Maturation of locomotor and Fos responses to the NMDA antagonists, PCP and MK-801. Dev Brain Res 122: 91-95.
30. Jellish WS, Murdoch J, Kindel G, Zhang X, White FA (2005). The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. Exp Brain Res 167: 526-534.
31. Jentsch JD, Anzivino LA (2004). A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats. Psychopharmacology 175: 76-83.
32. Kamisaki Y, Hamahashi T, Hamada T, Maeda K, Itoh T (1992). Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions. Eur J Pharmacol 217: 57-63.
33. Kawahara H, Kawahara Y, Westerink BH (2001). The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis. Eur J Pharmacol 418: 177-186.
34. Keseberg U, Schmidt WJ (1993). Tetrahydroaminoacridine attenuates dizocilpine-induced behavioural changes. Behav Brain Res 53: 113-118.
35. Kesner RP, Rogers J (2004). An analysis of independence and interactions of brain substrates that subserve multiple attributes, memory systems, and underlying processes. Neurobiol Learn Mem 82: 199-215.
36. Kim SH, Price MT, Olney JW, Farber NB (1999). Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and alpha2-adrenergic agonists. Mol Psychiatry 4: 344-352.
37. Kohler S, Black SE, Sinden M, Szekely C, Kidron D, Parker JL et al (1998). Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. Neuropsychologia 36: 901-914.
38. Kretschmer BD, Fink S (1999). Spatial learning deficit after NMDA receptor blockade and state-dependency. Behav Pharmacol 10: 423-428.
39. Lewis DA, Moghaddam B (2006). Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol 63: 1372-1376.
40. Li BM, Mao ZM, Wang M, Mei ZT (1999). Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology 21: 601-610.
41. Liu P, Bilkey DK (1999). The effect of excitotoxic lesions centered on the perirhinal cortex in two versions of the radial arm maze task. Behav Neurosci 113: 672-682.
42. Marcus MM, Jardemark KE, Wadenberg ML, Langlois X, Hertel P, Svensson TH (2005). Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat. Int J Neuropsychopharmacol 8: 315-327.
43. Marrs W, Kuperman J, Avedian T, Roth RH, Jentsch JD (2005). Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology 30: 1500-1510.
44. McCann DJ, Rabin RA, Winter JC (1987). Interactions of clonidine with phencyclidine and ketamine: studies of radial maze performance and righting reflex in rats. Pharmacol Biochem Behav 26: 23-28.
45. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA et al (1999). MRI anatomy of schizophrenia. Biol Psychiatry 45: 1099-1119.
46. Moghaddam B, Adams B, Verma A, Daly D (1997). Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17: 2921-2927.
47. Moghaddam B, Adams BW (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281: 1349-1352.
48. National Research Council (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press: Washington DC.
49. Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK, Hershey T et al (1999). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology 20: 106-118.
50. O'Donnell P, Lewis BL, Weinberger DR, Lipska BK (2002). Neonatal hippocampal damage alters electrophysiological properties of prefrontal cortical neurons in adult rats. Cereb Cortex 12: 975-982.
51. Ogren SO, Goldstein M (1994). Phencyclidine- and dizocilpine-induced hyperlocomotion are differentially mediated. Neuropsychopharmacology 11: 167-177.
52. Olney JW, Farber NB (1995). Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 998-1007.
53. Olney JW, Wozniak DF, Farber NB (1998). Glutamate receptor dysfunction and Alzheimer's disease. Restor Neurol Neurosci 13: 75-83.
54. Paxinos G, Watson C (1986). The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press: Sydney.
55. Riekkinen M, Laakso MP, Jakala P (1999). Clonidine impairs sustained attention and memory in Alzheimer's disease. Neuroscience 92: 975-982.
56. Riekkinen Jr P, Riekkinen M (1999). THA improves word priming and clonidine enhances fluency and working memory in Alzheimer's disease. Neuropsychopharmacology 20: 357-364.
57. Roe DL, Bardgett ME, Csernansky CA, Csernansky JG (1998). Induction of fos protein by antipsychotic drugs in rat brain following kainic acid-induced limbic-cortical neuronal loss. Psychopharmacology 138: 151-158.
58. Sacchetti G, Bernini M, Gobbi M, Parini S, Pirona L, Mennini T et al (2001). Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 363: 66-72.
59. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996). Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci 93: 3908-3913.
60. Sirvio J, Riekkinen Jr P, Vajanto I, Koivisto E, Riekkinen PJ (1991). The effects of guanfacine, alpha-2 agonist, on the performance of young and aged rats in spatial navigation task. Behav Neural Biol 56: 101-107.
61. Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A et al (2007). Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 129: 397-410.
62. Yoshihara T, Ichitani Y (2004). Hippocampal N-methyl-D-aspartate receptor-mediated encoding and retrieval processes in spatial working memory: delay-interposed radial maze performance in rats. Neuroscience 129: 1-10.
63. Zhang HT, Huang Y, Suvarna NU, Deng C, Crissman AM, Hopper AT et al (2005). Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology 179: 613-619.