Mutation of the α2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine

Journal of Neuroscience

Volumn 22, Issue 19, 2002, Pages 8771-8777

  Franowicz, Jenna S ^a   Kessler, Lynn E ^a   Dailey Borja, Catherine M ^a   Kobilka, Brian K ^b   Limbird, Lee E ^c   Arnsten, Amy F T ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenoceptor subtype; Attention deficit hyperactivity disorder; Delayed alternation; Mice; Neuropsychiatric disorder; Norepinephrine; Prefrontal cortex

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; GUANFACINE; ALPHA 2 ADRENERGIC RECEPTOR; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BRAIN FUNCTION; BRAIN INJURY; COGNITION; CONTROLLED STUDY; DRUG TARGETING; GENE MUTATION; KNOCKOUT MOUSE; LEARNING; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; POINT MUTATION; POSTSYNAPTIC MEMBRANE; PREFRONTAL CORTEX; PRIORITY JOURNAL; TASK PERFORMANCE; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MALE; MOUSE MUTANT; PHYSIOLOGY; SHORT TERM MEMORY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BEHAVIOR, ANIMAL; COGNITION; GUANFACINE; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; POINT MUTATION; PREFRONTAL CORTEX; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0036771838     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-19-08771.2002     Document Type: Article

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