Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury

Critical Care Medicine

Volumn 36, Issue 6, 2008, Pages 1873-1879

  Boost, Kim A ^a   Hoegl, Sandra ^a   Dolfen, Andrea ^a   Czerwonka, Holger ^a   Scheiermann, Patrick ^a   Zwissler, Bernhard ^a   Hofstetter, Christian ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Inhalation; Interleukin 1 ; Levosimendan; Macrophage inflammatory protein 1; Rat; Ventilator induced lung injury

Indexed keywords

AUTACOID; GELATIN; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; LEVOSIMENDAN; MACROPHAGE INFLAMMATORY PROTEIN 2; NITRIC OXIDE; SOLVENT; CARBON DIOXIDE; CARDIOTONIC AGENT; CYTOKINE; HYDRAZONE DERIVATIVE; MACROPHAGE INFLAMMATORY PROTEIN; OXYGEN; PYRIDAZINE DERIVATIVE; SIMENDAN; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL EVALUATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS EXCHANGE; HEART RIGHT VENTRICLE FAILURE; HYPERTRANSLUCENT LUNG; HYPOXIC LUNG VASOCONSTRICTION; INTENSIVE CARE; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; LUNG LAVAGE; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; MEDIATOR; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SURVIVAL TIME; UNIVERSITY HOSPITAL; VENTILATOR; ZYMOGRAPHY; ACID BASE BALANCE; ANIMAL; BLOOD; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; SURVIVAL RATE; VASCULARIZATION; VENTILATOR ASSOCIATED PNEUMONIA; WISTAR RAT;

ACID-BASE EQUILIBRIUM; ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CARBON DIOXIDE; CARDIOTONIC AGENTS; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDRAZONES; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENOUS; INTERLEUKIN-1BETA; LUNG; MACROPHAGE INFLAMMATORY PROTEINS; MACROPHAGES, ALVEOLAR; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; OXYGEN; PNEUMONIA, VENTILATOR-ASSOCIATED; PYRIDAZINES; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; SURVIVAL RATE; VASODILATOR AGENTS;

EID: 45149117353     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181743e63     Document Type: Article

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