Erythropoietin and the endothelium - A promising link?

European Journal of Clinical Investigation

Volumn 38, Issue 7, 2008, Pages 457-461

  Fliser, D ^a   Bahlmann, F H ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

AKT activation; Erythropoietin (EPO); Nitric oxide; Vascular protection

Indexed keywords

ACETYLCHOLINE; ERYTHROPOIETIN; NITRIC OXIDE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PROTECTIVE AGENT; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN;

CARDIOVASCULAR SYSTEM; CELL REGENERATION; DRUG MECHANISM; ENDOTHELIUM; ENZYME ACTIVATION; HUMAN; ISCHEMIA; MEDICINE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REVIEW; TISSUE INJURY;

CELL DIFFERENTIATION; ENDOTHELIAL CELLS; ENDOTHELIUM; ERYTHROPOIETIN; HUMANS; NITRIC OXIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; VASCULAR DISEASES;

EID: 45149116201     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.01968.x     Document Type: Review

References (34)

1. Goldman SA, Nedergaard M. Erythropoietin strikes a new cord. Nat Med 2002 8 : 785 7.
2. Frank SJ. Receptor dimerization in GH and erythropoietin action - it takes two to tango, but how? Endocrinology 2000 143 : 2 10.
3. Seubert N, Royer Y, Staerk J, Kubatzky KF, Moucadel V, Krishnakumar S et al. Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell 2003 12 : 1239 50.
4. Jubinsky PT, Krijanovski OI, Nathan DG, Tavernier J, Sieff CA. The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood 1997 90 : 1867 73.
5. Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci USA 2004 101 : 14907 12.
6. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993 74 : 227 36.
7. Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X (L) induction. Cell 1999 98 : 181 91.
8. Wojchowski DM, Gregory RC, Miller CP, Pandit AK, Pircher TJ. Signal transduction in the erythropoietin receptor system. Exp Cell Res 1999 253 : 143 56.
9. Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997 88 : 435 7.
10. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y et al. AKT phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997 : 91.
11. Bao H, Jacobs-Helber SM, Lawson AE, Penta K, Wickrema A, Sawyer ST. Protein kinase B (c-AKT), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). Blood 1999 93 : 3757 73.
12. Beleslin-Cokic BB, Cokic VPYuX, Weksler BB, Schechter AN, Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood 2004 104 : 2073 80.
13. d'Uscio LV, Smith LA, Santhanam AV, Richardson D, Nath KA, Katusic ZS. Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin. Hypertension 2007 49 : 1142 8.
14. Bahlman FH, Kielstein JT, Haller H, Fliser D. Erythropietin and progression of CKD. Kidney Int Suppl 2007 107 : S21 5.
15. Juul SE, Yachnis AT, Christensen RD. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus. Early Hum Dev 1998 52 : 235 49.
16. Kertesz N, Wu J, Chen TH, Sucov HM, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol 2004 276 : 101 10.
17. Anagnostou A, Lee ES, Kessimian N, Levinson R, Steiner M. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 1990 87 : 5978 82.
18. Carlini RG, Alonzo EJ, Dominguez J, Blanca I, Weisinger JR, Rothstein M et al. Effect of recombinant human erythropoietin on endothelial cell apoptosis. Kidney Int 1999 55 : 546 53.
19. Chong ZZ, Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of AKT1 and mitochondrial modulation of cysteine proteases. Circulation 2002 106 : 2973 9.
20. Carlini RG, Reyes AA, Rothstein M. Recombinant human erythropoietin stimulates angiogenesis in vitro. Kidney Int 1995 47 : 740 5.
21. Ribatti D, Presta M, Vacca A, Ria R, Giuliani R, Dell'Era P et al. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood 1999 93 : 2627 36.
22. Bahlmann FH, Song R, Boehm SM, Mengel M, von Wasielewski R, Lindschau C et al. Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial AKT and attenuates progressive organ failure. Circulation 2004 100 : 1006 12.
23. Bahlmann FH, De Groot K, Spandau JM, Landry AL, Hertel B, Duckert T et al. Erythropoietin regulates endothelial progenitor cells. Blood 2004 103 : 921 6.
24. Bahlmann FH, deGroot K, Duckert T, Niemczyk E, Bahlmann E, Boehm SM et al. Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin. Kidney Int 2003 64 : 1648 52.
25. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999 85 : 221 8.
26. Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG. Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension 2005 46 : 7 18.
27. Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C et al. Erythropoietin is a potent physiological stimulus for endothelial progenitor cell mobilization. Blood 2003 102 : 1340 6.
28. Urao N, Okigaki M, Yamada H, Aadachi Y, Matsuno K, Matsui A et al. Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via AKT-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Circ Res 2006 98 : 1405 13.
29. Westenbrink BD, Lipsic E, van der Meer P, van der Harst P, Oeseburg H, Du Marchie Sarvaas GJ et al. Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization. Eur Heart J 2007 28 : 2018 27.
30. Sorrentino SA, Bahlmann FH, Besler C, Müller M, Schulz S, Kirchhoff N et al. Oxidant stress impairs in vivo re-endothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: Restoration by peroxisome proliferator-activator receptor-gama agonist rosiglitazone. Circulation 2007 116 : 163 73.
31. Fuste B, Serradell M, Escolar G, Cases A, Mazzara R, Castillo R et al. Erythropoietin triggers a signalling pathway in endothelial cells and increases the thrombogenicity of their extracellular matrices in vitro. Thromb Haemost 2002 88 : 678 8.
32. Lindenblatt N, Menger MD, Klar E, Vollmar B. Darbepoetin-alpha does not promote microvascular thrombus formation in mice: role of eNOS-dependent protection through platelet and endothelial cell deactivation. Arterioscler Thromb Vasc Biol 2007 27 : 1191 8.
33. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 2004 305 : 239 42.
34. Coleman TR, Westenfelder C, Tögel FE, Yang Y, Hu Z, Swenson L et al. Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities. Proc Natl Acad Sci USA 2006 103 : 5965 70.