Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle

Journal of Applied Physiology

Volumn 104, Issue 5, 2008, Pages 1436-1441

  Daussin, Frédéric N ^a,b   Zoll, Joffrey ^a,b,f   Ponsot, Elodie ^a,b   Dufour, Stéphane P ^a,b   Doutreleau, Stéphane ^a,b   Lonsdorfer, Evelyne ^a,b   Ventura Clapier, Renée ^c,d   Mettauer, Bertrand ^a,b,e   Piquard, François ^a,b   Geny, Bernard ^a,b   Richard, Ruddy ^a,b  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Universite Paris Sud   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e Civil Hospital   (France)

^f HÔPITAL CIVIL   (France)

Author keywords

Exercise training; Metabolism

Indexed keywords

CARBOHYDRATE; FATTY ACID;

ADAPTATION; ADULT; ARTICLE; ATHLETE; CARBOHYDRATE METABOLISM; ENDURANCE; EXERCISE; FATTY ACID OXIDATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; METABOLIC PARAMETERS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE BIOPSY; MUSCLE CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SKELETAL MUSCLE; TRAINING; VASTUS LATERALIS MUSCLE; CROSS-SECTIONAL STUDY; ELECTRON TRANSPORT; FITNESS; KINETICS; LUNG GAS EXCHANGE; MALE; METABOLISM; MUSCLE MITOCHONDRION; PHOSPHORYLATION; PHYSIOLOGY; SPORT;

ADAPTATION, PHYSIOLOGICAL; ADULT; CARBOHYDRATE METABOLISM; CROSS-SECTIONAL STUDIES; ELECTRON TRANSPORT; EXERCISE; FATTY ACIDS; FEMALE; HUMANS; KINETICS; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHOSPHORYLATION; PHYSICAL FITNESS; PULMONARY GAS EXCHANGE; SPORTS;

EID: 45149104369     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01135.2007     Document Type: Article

References (45)

1. Baldwin KM, Tipton CM. Work and metabolic patterns of fast and slow twitch skeletal muscle contracting in situ. Pflügers Arch 334: 345-356, 1972.
2. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60: 2020-2027, 1986.
3. Boon H, Jonkers RA, Koopman R, Blaak EE, Saris WH, Wagenmakers AJ, Vanl LJ. Substrate source use in older, trained males after decades of endurance training. Med Sci Sports Exerc 39: 2160-2170, 2007.
4. Brooks GA. Importance of the "crossover" concept in exercise metabolism. Clin Exp Pharmacol Physiol 24: 889-895, 1997.
5. Brooks GA, Donovan CM. Effect of endurance training on glucose kinetics during exercise. Am J Physiol Endocrinol Metab 244: E505-E512, 1983.
6. Brooks GA, Mercier J. Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept. J Appl Physiol 76: 2253-2261, 1994.
7. Carter SL, Rennie C, Tarnopolsky MA. Substrate utilization during endurance exercise in men and women after endurance training. Am J Physiol Endocrinol Metab 280: E898-E907, 2001.
8. Coggan AR. The glucose crossover concept is not an important new concept in exercise metabolism. Clin Exp Pharmacol Physiol 24: 896-900, 1997.
9. Coggan AR, Kohrt WM, Spina RJ, Bier DM, Holloszy JO. Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. J Appl Physiol 68: 990-996, 1990.
10. Coggan AR, Raguso CA, Williams BD, Sidossis LS, Gastaldelli A. Glucose kinetics during high-intensity exercise in endurance-trained and untrained humans. J Appl Physiol 78: 1203-1207, 1995.
11. Coyle EF, Coggan AR, Hopper MK, Walters TJ. Determinants of endurance in well-trained cyclists. J Appl Physiol 64: 2622-2630, 1988.
12. Fluck M. Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli. J Exp Biol 209: 2239-2248, 2006.
13. Gnaiger E, Lassnig B, Kuznetsov A, Rieger G, Margreiter R. Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol 201: 1129-1139, 1998.
14. Green HJ, Sutton JR, Wolfel EE, Reeves JT, Butterfield GE, Brooks GA. Altitude acclimatization and energy metabolic adaptations in skeletal muscle during exercise. J Appl Physiol 73: 2701-2708, 1992.
15. Hansen JE, Sue DY, Wasserman K. Predicted values for clinical exercise testing. Am Rev Respir Dis 129: S49-S55, 1984.
16. Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56: 831-838, 1984.
17. Hood DA, Irrcher I, Ljubicic V, Joseph AM. Coordination of metabolic plasticity in skeletal muscle. J Exp Biol 209: 2265-2275, 2006.
18. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc 35: 95-104, 2003.
19. Hoppeler H, Howald H, Conley K, Lindstedt SL, Claassen H, Vock P, Weibel ER. Endurance training in humans: aerobic capacity and structure of skeletal muscle. J Appl Physiol 59: 320-327, 1985.
20. Hurley BF, Nemeth PM, Martin WH 3rd, Hagberg JM, Dalsky GP, Holloszy JO. Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60: 562-567, 1986.
21. Jeukendrup AE, Mensink M, Saris WH, Wagenmakers AJ. Exogenous glucose oxidation during exercise in endurance-trained and untrained subjects. J Appl Physiol 82: 835-840, 1997.
22. Kjaer M, Farrell PA, Christensen NJ, Galbo H. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol 61: 1693-1700, 1986.
23. Klein S, Coyle EF, Wolfe RR. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Physiol Endocrinol Metab 267: E934-E940, 1994.
24. Kristiansen S, Gade J, Wojtaszewski JF, Kiens B, Richter EA. Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. J Appl Physiol 89: 1151-1158, 2000.
25. N'Guessan B, Zoll J, Ribera F, Ponsot E, Lampert E, Ventura-Clapier R, Veksler V, Mettauer B. Evaluation of quantitative and qualitative aspects of mitochondrial function in human skeletal and cardiac muscles. Mol Cell Biochem 256-257: 267-280, 2004.
26. O'Brien MJ, Viguie CA, Mazzeo RS, Brooks GA. Carbohydrate dependence during marathon running. Med Sci Sports Exerc 25: 1009-1017, 1993.
27. Ponsot E, Dufour SP, Zoll J, Doutrelau S, N'Guessan B, Geny B, Hoppeler H, Lampert E, Mettauer B, Ventura-Clapier R, Richard R. Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol 100: 1249-1257, 2006.
28. Ponsot E, Zoll J, N'Guessan B, Ribera F, Lampert E, Richard R, Veksler V, Ventura-Clapier R, Mettauer B. Mitochondrial tissue specificity of substrates utilization in rat cardiac and skeletal muscles. J Cell Physiol 203: 479-486, 2005.
29. Proctor DN, Sinning WE, Walro JM, Sieck GC, Lemon PW. Oxidative capacity of human muscle fiber types: effects of age and training status. J Appl Physiol 78: 2033-2038, 1995.
30. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol Endocrinol Metab 265: E380-E391, 1993.
31. Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T. Mitochondrial threshold effects. Biochem J 370: 751-762, 2003.
32. Rossignol R, Letellier T, Malgat M, Rocher C, Mazat JP. Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases. Biochem J 347: 45-53, 2000.
33. Sahlin K, Mogensen M, Bagger M, Fernstrom M, Pedersen PK. The potential for mitochondrial fat oxidation in human skeletal muscle influences whole body fat oxidation during low-intensity exercise. Am J Physiol Endocrinol Metab 292: E223-E230, 2007.
34. Schmitt B, Fluck M, Decombaz J, Kreis R, Boesch C, Wittwer M, Graber F, Vogt M, Howald H, Hoppeler H. Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes. Physiol Genomics 15: 148-157, 2003.
35. Sial S, Coggan AR, Hickner RC, Klein S. Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects. Am J Physiol Endocrinol Metab 274: E785-E790, 1998.
36. Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tarnopolsky SN, Devries MC, Hamadeh MJ. Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity. Am J Physiol Regul Integr Comp Physiol 292: R1271-R1278, 2007.
37. Tonkonogi M, Walsh B, Svensson M, Sahlin K. Mitochondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J Physiol 528: 379-388, 2000.
38. van Loon LJ, Greenhaff PL, Constantin-Teodosiu D, Saris WH, Wagenmakers AJ. The effects of increasing exercise intensity on muscle fuel utilisation in humans. J Physiol 536: 295-304, 2001.
39. van Loon LJ, Jeukendrup AE, Saris WH, Wagenmakers AJ. Effect of training status on fuel selection during submaximal exercise with glucose ingestion. J Appl Physiol 87: 1413-1420, 1999.
40. Walsh B, Tonkonogi M, Soderlund K, Hultman E, Saks V, Sahlin K. The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol 537: 971-978, 2001.
41. Wasserman K, Beaver WL, Whipp BJ. Gas exchange theory and the lactic acidosis (anaerobic) threshold. Circulation 81: II14 -II30, 1990.
42. Weston AR, Myburgh KH, Lindsay FH, Dennis SC, Noakes TD, Hawley JA. Skeletal muscle buffering capacity and endurance performance after high-intensity interval training by well-trained cyclists. Eur J Appl Physiol 75: 7-13, 1997.
43. Zoll J, Koulmann N, Bahi L, Ventura-Clapier R, Bigard AX. Quantitative and qualitative adaptation of skeletal muscle mitochondria to increased physical activity. J Cell Physiol 194: 186-193, 2003.
44. Zoll J, N'Guessan B, Ribera F, Lampert E, Fortin D, Veksler V, Bigard X, Geny B, Lonsdorfer J, Ventura-Clapier R, Mettauer B. Preserved response of mitochondrial function to short-term endurance training in skeletal muscle of heart transplant recipients. J Am Coll Cardiol 42: 126-132, 2003.
45. Zoll J, Sanchez H, N'Guessan B, Ribera F, Lampert E, Bigard X, Serrurier B, Fortin D, Geny B, Veksler V, Ventura-Clapier R, Mettauer B. Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle. J Physiol 543: 191-200, 2002.