Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 5 37-5, 1998, Pages

  Sial, Shahid ^b   Coggan, Andrew R ^b   Hickner, Robert C ^b   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Aging; Free fatty acids; Glucose; Glycerol; Stable isotopes

Indexed keywords

CARBOHYDRATE; FAT; FATTY ACID; GLUCOSE; GLYCEROL;

AGED; ARTICLE; BODY COMPOSITION; CALORIMETRY; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FATTY ACID METABOLISM; FEMALE; GLUCOSE METABOLISM; HUMAN; LIPID METABOLISM; LIPOLYSIS; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRAINING;

EID: 0031803389     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.5.e785     Document Type: Article

References (37)

1. Andersen, P., and J. Henriksson. Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise. J. Physiol. (Lond.) 270: 677-690, 1977.
2. Carraro, F., C. A. Stuart, W. H. Hartl, J. I. Rosenblatt, and R. R. Wolfe. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E470-E476, 1990.
3. Coggan, A. R., W. M. Kohrt, R. J. Spina, D. M. Bier, and J. O. Holloszy. Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. J. Appl. Physiol. 68: 990-996, 1990.
4. Coggan, A. R., R. J. Spina, D. S. King, M. A. Rogers, M. Brown, P. M. Nemeth, and J. O. Holloszy. Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J. Appl. Physiol. 72: 1780-1786, 1992.
5. Coggan, A. R., R. J. Spina, D. S. King, M. A. Rogers, M. Brown, P. M. Nemeth, and J. O. Holloszy. Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women. J. Gerontol. 47: B71-B76, 1992.
6. Coggan, A. R., R. J. Spina, W. M. Kohrt, and J. O. Holloszy. Effect of prolonged exercise on muscle citrate concentration before and after endurance training in men. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E215-E220, 1993.
7. Coyle, E. F., A. E. Jeukendrup, A. J. M. Wagenmakers, and W. H. M. Saris. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E268-E275, 1997.
8. Frayn, K. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
9. Goran, M. I., and E. T. Poehlman, Endurance training does not enhance total energy expenditure in healthy elderly persons. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E950-E957, 1992.
10. Hagberg, J. M., S. J. Montain, W. H. I. Martin, and A. A. Ehsani. Effect of exercise training in 60- to 69-year-old persons with essential hypertension. Am. J. Cardiol. 64: 348-353, 1991.
11. Hales, C. N., and P. J. Randle. Immunoassay of insulin with insulin antibody precipitate. Biochem. J. 88: 137-146, 1963.
12. Holloszy, J. O., and E. F. Coyle. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 56: 831-838, 1984.
13. Hurley, B. F., P. M. Nemeth, W. H. Martin III, J. M. Hagberg, G. P. Dalsky, and J. O. Holloszy. Muscle triglyceride utlization during exercise: effect of training. J. Appl. Physiol. 60: 562-567, 1986.
14. Hussain, M. N., and C. R. Benedict. Radioenzymatic microassay for simultaneous estimations of dopamine, norepinephrine, and epinephrine in plasma, urine, and tissues. Clin. Chem. 31: 1861-1864, 1985.
15. Jansson, E., and L. Kaijser. Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. J. Appl. Physiol. 62: 999-1005, 1987.
16. Kiens, B., S. Kristiansen, P. Jensen, E. A. Richter, and L. P. Turcotte. Membrane associated fatty acid binding protein (FAB-Ppm) in human skeletal muscle is increased by endurance training. Biochem. Biophys. Res. Commun. 231: 463-465, 1997.
17. Kiens, B., and H. Lithell. Lipoprotein metabolism influenced by training-induced changes in human skeletal muscle. J. Clin. Invest. 83: 558-564, 1988.
18. Klein, S., E. F. Coyle, and R. R. Wolfe. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E934-E940, 1994.
19. Klein, S., Y. Sakurai, J. A. Romjin, and R. M. Carroll. Progressive alterations in lipid and glucose metabolism during short-term fasting in humans. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E801-E806, 1993.
20. Klein, S., J. M. Weber, E. F. Coyle, and R. R. Wolfe. Effect of endurance training on glycerol kinetics during strenuous exercise in humans. Metabolism 45: 357-361, 1996.
21. 2max to training in 60-71 yr olds. J. Appl. Physiol. 71: 2004-2011, 1991.
22. Kohrt, W. M., K. A. Obert, and J. O. Holloszy. Exercise training improves fat distribution patterns in 60- to 70-year-old men and women. J. Gerontol. 47: M99-M105, 1992.
23. Martin, W. H. I., G. P. Dalsky, B. F. Hurley, D. E. Mathews, D. M. Bier, J. M. Hagberg, M. A. Rogers, D. S. King, and J. O. Holloszy. Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E708-E714, 1993.
24. McDonald-Gibson, R. G., and M. Young. The use of an automatic solids injection system for quantitative determination of plasma long chain non-esterified fatty acids by gas-lipid chromatography. Clin. Chim. Acta 53: 117-126, 1974.
25. McGuire, E. A. H., J. H. Helderman, J. D. Tobin, R. Andres, and M. Berman. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J. Appl. Physiol. 41: 565-573, 1976.
26. Meredith, C. N., W. R. Frontera, E. C. Fisher, V. A. Hughes, J. C. Herland, J. Edwards, and W. J. Evans. Peripheral effects of endurance training in young and old subjects. J. Appl. Physiol. 66: 2844-2849, 1989.
27. Molé, P. A., L. B. Oscai, and J. O. Holloszy. Adaptation of muscle to exercise. Increase in levels of palmityl CoA synthetase, carnitine palmityltransferase, and palmityl CoA dehydrogenase, and in the capacity to oxidize fatty acids. J. Clin. Invest. 50: 2323-2330, 1971.
28. Olsson, A. G., B. Eklund, L. Kaijser, and L. A. Carlson. Extraction of endogenous plasma triglycerides by the working human forearm muscle in the fasting state. Scand. J. Clin. Lab. Invest. 35: 231-236, 1975.
29. Phillips, S. M., H. J. Green, M. A. Tarnopolsky, G. J. F. Heigenhauser, and S. M. Grant. Progressive effect of endurance training on metabolic adaptations in working skeletal muscle. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E265-E272, 1996.
30. Phillips, S. M., H. J. Green, M. A. Tarnapolsky, G. J. F. Heigenhauser, R. E. Hill, and S. M. Grant. Effects of training duration on substrate turnover and oxidation during exercise. J. Appl. Physiol. 81: 2182-2191, 1996.
31. Poehlman, E. T., A. W. Gardner, P. J. Arciero, M. I. Goran, and J. Calles-Escandon. Effects of endurance training on total fat oxidation in elderly persons. J. Appl. Physiol. 76: 2281-2287, 1994.
32. Proctor, D. N., W. E. Sinning, J. M. Walro, G. C. Sieck, and P. W. R. Lemon. Oxidative capacity of human muscle fiber types: effects of age and training status. J. Appl. Physiol. 78: 2033-2038, 1995.
33. Schwartz, R. S., W. P. Shuman, V. Larson, K. C. Cain, G. W. Fellingham, J. C. Beard, S. E. Kahn, J. R. Stratton, M. D. Cerqueira, and I. B. Abrass. The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 40: 545-551, 1991.
34. Sial, S., A. R. Coggan, R. Carroll, J. Goodwin, and S. Klein. Fat and carbohydrate metabolism during exercise in elderly and young subjects. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E983-E989, 1996.
35. Sidossis, L. S., A. Gastaldelli, S. Klein, and R. R. Wolfe. Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E1065-E1070, 1997.
36. Spina, R. J., T. Ogawa, W. M. Kohrt, W. H. Martin III, J. O. Holloszy, and A. A. Ehsani. Differences in cardiovascular adaptations to endurance exercise training between older men and women. J. Appl. Physiol. 75: 849-855, 1993.
37. Steele, R. Influence of glucose loading and of injected insulin on hepatic glucose output. Ann. NY Acad. Sci. 82: 420-430, 1959.