Plasma levels of tumor necrosis factor-alpha (TNF-α) are essentially dependent on visceral fat amount in type 2 diabetic patients

Diabetes and Metabolism

Volumn 26, Issue 3, 2000, Pages 178-182

  Bertin, E ^b   Nguyen, P ^a   Guenounou, M ^a   Durlach, V ^c   Potron, G ^a   Leutenegger, M ^c  

^a Cytokines Explor Unit Hôpital   (France)

^b REIMS UNIVERSITY HOSPITAL   (France)

^c NONE

Author keywords

Diabetes; Human; TNF ; Visceral adipose tissue

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; ORAL ANTIDIABETIC AGENT; SULFONYLUREA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY FAT; BODY MASS; CARDIOVASCULAR RISK; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TREATMENT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; VISCERA;

ADIPOSE TISSUE; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; COHORT STUDIES; DENSITOMETRY, X-RAY; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRANCE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MIDDLE AGED; REGRESSION ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA; VISCERA;

EID: 0033920370     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science, 1996, 271, 665-668.
2. Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-alpha induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT-4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem, 1997, 272, 971-976.
3. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α : direct role in obesity-linked insulin resistance. Science, 1993, 259, 87-91.
4. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature, 1997, 389, 610-614.
5. Ventre J, Doebber T, Wu M, et al. Targeted disruption of the tumor necrosis factor-α gene. Metabolic consequences in obese and non-obese mice. Diabetes, 1997, 46, 1526-1531.
6. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest, 1995, 95, 2111-2119.
7. Hofmann C, Lorenz K, Braithwaite SS, et al. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994, 134, 264-270.
8. Yamakawa T, Tanaka S, Yamakawa Y, et al. Augmented production of tumor necrosis factor-alpha in obese mice. Clin Immunol Immunopathol, 1995, 75, 51-56.
9. Pfeiffer A, Janott J, Möhlig M, et al. Circulating tumor necrosis factor alpha is elevated in male but not in female patients with type II diabetes mellitus. Harm Metab Res, 1997, 29, 111-114.
10. Winkler G, Salamon F, Salamon D, Speer G, Simon K, Cseh K. Elevated serum tumor necrosis factor-alpha levels can contribute to the insulin resistance in type II (non-insulin-dependent) diabetes and in obesity. Diabetologia, 1998, 41, 860-862.
11. Katsuki A, Sumida Y, Murashima S, et al. Serum levels of tumor necrosis factor-α are increased in obese patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab, 1998, 83, 859-862.
12. Morohoshi M, Fujisawa K, Uchimura I, Numano F. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Diabetes, 1996, 45, 954-959.
13. Lohman TG. Dual Energy X-ray Absorptiometry. In : Roche AF, Heymsfield SB, Lohman TG, eds. « Human Body Composition ». vol 4. Champaign IL. Human Kinetics, 1996, 63-78.
14. Borkan GA, Gerzof SG, Robbins AH. Assessment of abdominal fat content by computed tomography. Am J Clin Nutr, 1982, 36, 172-177.
15. WHO document : Measuring obesity - classification and description of anthropometric data. Copenhagen : WHO Regional Office for Europe. Nutrition Unit. # EUR/ICP/NUT 125, 1988.
16. Kroder G, Bossenmainer B, Kellerer M, et al. Tumor necrosis factor-α and hyperglycemia-induced insulin resistance, evidence for different mechanisms and different effects on insulin signaling. J Clin Invest, 1996, 97, 1471-1477.
17. Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev, 1994, 74, 761-811.
18. Montague CT, Prins JB, Sanders L, et al. Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes, 1998, 47, 1384-1391.
19. Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha in vivo. J Clin Endocrinol Metab, 1997, 82, 4196-4200.
20. Samad F, Yamamoto K, Loskutoff DJ. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest. 1996, 97, 37-46.
21. Urata Y, Yamamoto H, Goto S, et al. Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1 beta and tumor necrosis factor-alpha in mouse endothelial cells. J Biol Chem, 1996, 271, 15146-15152.
22. Feingold KR, Soued M, Adi S, et al. Tumor necrosis factor-increased hepatic very-low-density lipoprotein production and increased serum triglyceride levels in diabetic rats. Diabetes, 1990, 39, 1569-1574.
23. Feingold KR, Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes, 1992, 41 (suppl.), 97-101.