2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: A new class of P-glycoprotein-mediated drug efflux inhibitors

Medicinal Chemistry

Volumn 4, Issue 3, 2008, Pages 194-205

  Carta, Antonio ^a   Piras, Sandra ^a   Paglietti, Giuseppe ^a   Pricl, Sabrina ^b   La Colla, Paolo ^c   Busonera, Bernardetta ^c   Loddo, Roberta ^c  

^a Dipartimento Farmaco Chimico Tossicologico   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

2(3) Aryl thio(oxy) methylquinoxalines; Antipoliferative activity; Doxorubicin; Etoposide; MRP pump; Multidrug resistance; P glycoprotein inhibitors; Vincristine

Indexed keywords

2 ARYLTHIOMETHYL 3 BENZYLOXY 6 TRIFLUOROMETHYLQUINOXALINE DERIVATIVE; 2,3 BIS(ARYLOXYMETHYL) 6 TRIFLUOROMETHYLQUINOXALINE DERIVATIVE; 3 ARYLTHIOMETHYL 1 BENZYL 7 TRIFLUOROMETHYLQUINOXALIN 2 ONE DERIVATIVE; 3 ARYLTHIOMETHYL 1,6 DIMETHYLQUINOXALIN 2 ONE DERIVATIVE; ARYLPHENOXYMETHYLQUINOXALINE DERIVATIVE; DOXORUBICIN; ETOPOSIDE; FUSED CARBON NITROGEN HETEROCYCLE; GLYCOPROTEIN P INHIBITOR; QUINOXALINE DERIVATIVE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; P-GLYCOPROTEIN; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 45149097944     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608784325197     Document Type: Article

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