Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells

Leukemia

Volumn 22, Issue 6, 2008, Pages 1258-1262

  Kong, G ^a   Wang, D ^a   Wang, H ^a   Wu, J ^a   Bielawski, J ^b   Konopleva, M ^c   Andreeff, M ^c   Ruvolo, P P ^d   Maurer, B J ^a,e  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 IMIDAZOLIDE; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; CASPASE 3; CASPASE 8; CASPASE 9; CERAMIDE; CYTOTOXIC AGENT; FENRETINIDE; METHYL 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OATE; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN; THERMOZYMOCIDIN; TRITERPENOID;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CELL SURVIVAL; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MONOTHERAPY; OXYGEN TENSION; PRIORITY JOURNAL;

EID: 45149097642     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2405023     Document Type: Article

References (8)

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