Both IKKα and IKKβ are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-κB activity-independent manner

Experimental Cell Research

Volumn 314, Issue 11-12, 2008, Pages 2187-2198

  Song, Lun ^a,b   Li, Jingxia ^a   Hu, Meiru ^b   Huang, Chuanshu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

AP 1; Arsenite; Cell death; IKK; NF B

Indexed keywords

ACTIVATION PROTEIN 1; ARSENIC TRIOXIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P50; PROTEIN SUBUNIT; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR; ARSENOUS ACID DERIVATIVE; CELL CYCLE PROTEIN; CHUK PROTEIN, MOUSE; GADD45A PROTEIN, MOUSE; I KAPPA B KINASE; IKBKB PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ARSENITES; CELL CYCLE PROTEINS; CELLS, CULTURED; ENZYME ACTIVATION; FIBROBLASTS; I-KAPPA B KINASE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NUCLEAR PROTEINS; PROTEIN SUBUNITS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1;

EID: 45049087065     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.04.002     Document Type: Article

References (30)

1. Shaulian E., and Karin M. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4 (2002) E131-E136
2. Eferl R., and Wagner E.F. AP-1: A double-edged sword in tumorigenesis. Nat. Rev., Cancer 3 (2003) 859-868
3. Shaulian E., and Karin M. AP-1 in cell proliferation and survival. Oncogene 20 (2001) 2390-2400
4. Kolbus A., Herr I., Schreiber M., Debatin K.-M., Wagner E.F., and Angel P. c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol. Cell. Biol. 20 (2000) 575-582
5. Kasibhatla S., Brunner T., Genestier L., Echeverri F., Mahboubi A., and Green uD.R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-[kappa]B and AP-1. Mol. Cell 1 (1998) 543-551
6. Liao W.-T., Chang K.-L., Yu C.-L., Chen G.-S., Chang L.W., and Yu H.-S. Arsenic induces human keratinocyte apoptosis by the FAS//FAS ligand pathway, which correlates with alterations in nuclear factor-[kappa]B and activator protein-1 activity. J. Investig. Dermatol. 122 (2004) 125-129
7. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
8. Gruda M.C., Kovary K., Metz R., and Bravo R. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity. Oncogene 9 (1994) 2537-2547
9. Hill C.S., Wynne J., and Treisman R. Serum-regulated transcription by serum response factor (Srf)-a novel role for the DNA binding domain. EMBO J. 13 (1994) 5421-5432
10. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270 (1995) 16483-16486
11. Meyerson M., Counter C.M., Eaton E.N., Ellisen L.W., Steiner P., Caddle S.D., Ziaugra L., Beijersbergen R.L., Davidoff M.J., Liu Q., Bacchetti S., Haber D.A., and Weinberg R.A. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90 (1997) 785-795
12. Ghosh S., and Karin M. Missing pieces in the NF-[kappa]B puzzle. Cell 109 (2002) S81-S96
13. Hayden M.S., and Ghosh S. Signaling to NF-{kappa}B. Genes Dev. 18 (2004) 2195-2224
14. Arsura M., Panta G.R., Bilyeu J.D., Cavin L.G., Sovak M.A., Oliver A.A., Factor V., Heuchel R., Mercurio F., Thorgeirsson S.S., and Sonenshein G.E. Transient activation of NF-kB through a TAK1/IKK kinase pathway by TGF-1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22 (2003) 412-425
15. Krappmann D., Wegener E., Sunami Y., Esen M., Thiel A., Mordmuller B., and Scheidereit C. The I{kappa}B kinase complex and NF-{kappa}B act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol. Cell. Biol. 24 (2004) 6488-6500
16. Bode A.M., and Dong Z. The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit. Rev. Oncol./Hematol. 42 (2002) 5-24
17. Wu Y., Xiao S., and Zhu X.-D. MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol. 14 (2007) 832-840
18. Ouyang W., Ma Q., Li J., Zhang D., Liu Z.-g., Rustgi A.K., and Huang C. Cyclin D1 induction through I{kappa}B kinase {beta}/nuclear factor-{kappa}B pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes. Cancer Res. 65 (2005) 9287-9293
19. Yangchao Chen, M. C. L., H. Y., H. W., A.-Q. Z., J. Y., C.-k. H., G. K. L., M.-l. H., J. S., and H.-f. K. Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology 46 (2007) 200-208
20. Drobna Z., Jaspers I., Thomas D.J., and Styblo M. Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J. (2002) 02-0287fje
21. Song L., Li J., Zhang D., Liu Z.-g., Ye J., Zhan Q., Shen H.M., Whiteman M., and Huang C. IKK{beta} programs to turn on the GADD45{alpha}-MKK4-JNK apoptotic cascade specifically via p50 NF-{kappa}B in arsenite response. J. Cell Biol. 175 (2006) 607-617
22. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., and Lin A. Inhibition of JNK activation through NF-[kappa]B target genes. Nature 414 (2001) 313-317
23. Song L., Li J., Ye J., Yu G., Ding J., Zhang D., Ouyang W., Dong Z., Kim S.O., and Huang C. p85a acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol. Cell. Biol. 27 (2007) 2713-2731
24. Wu Z., W. J., Jacinto E., and Karin M. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol. Cell. Biol. 17 (1997) 7407-7416
25. Lin A., M. A., Martinetto H., Claret F.X., Lange-Carterm C., Mercurio F., Johnson G.L., and Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268 (1995) 286-290
26. Zarubin T., and Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15 (2005) 11-18
27. Huang C., Ma W.-Y., Li J., Goranson A., and Dong Z. Requirement of Erk, but not JNK, for Arsenite-induced Cell Transformation (1999)
28. Song H., Ki S.H., Kim S.G., and Moon A. Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells. Cancer Res. 66 (2006) 10487-10496
29. Wang X., and Studzinski G.P. The requirement for and changing composition of the activating protein-1 transcription factor during differentiation of human leukemia HL60 cells induced by 1,25-dihydroxyvitamin D3. Cancer Res. 66 (2006) 4402-4409
30. Adiseshaiah P., Papaiahgari S.R., Vuong H., Kalvakolanu D.V., and Reddy S.P. Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. J. Biol. Chem. 278 (2003) 47423-47433