Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2

Biochemical Pharmacology

Volumn 76, Issue 1, 2008, Pages 120-127

  Sun, Cheng ^a   Zhou, Jia ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Glucose utilization; HDAC2; Insulin sensitivity; Trichostatin A

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 2; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INSULIN; MICE; PHOSPHORYLATION; RECEPTOR, INSULIN; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 45049085648     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.04.004     Document Type: Article

References (32)

1. Wild S., Roglic G., Green A., Sicree R., and King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27 (2004) 1047-1053
2. Yach D., Stuckler D., and Brownell K.D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 12 (2006) 62-66
3. Satiel A.R., and Kahn C.R. Insulin signaling and the regulation o glucose and lipid metabolism. Nature 414 (2001) 799-806
4. Saltiel A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104 (2001) 517-529
5. Mokdad A.H., Ford E.S., Bowman B.A., Dietz W.H., Vinicor F., Bales V.S., et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289 (2003) 76-79
6. Otoguro K., Oiwa R., Iwai Y., Tanaka H., and Omura S. Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of Trichostatin A. J Antibiot 41 (1998) 461-468
7. Yoshida M., Kijima M., Akita M., and Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by Trichostatin A. J Biol Chem 265 (1990) 17174-17179
8. Hoshikawa Y., Kwon H.J., Yoshida M., Horinouchi S., and Beppu T. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 (1994) 189-197
9. Chen T., Sun H., Lu J., Zhao Y., Tao D., Li X., et al. Histone acetylation is involved in hsp 70 gene transcription regulatin in Drosophila melanogaster. Arch Biochem Biophys 15 (2002) 171-176
10. Aoyagi S., and Archer T.K. Dynamic histone acetylation/deacetylation with progesterone receptor-mediated transcription. Mol Endocrinol 21 (2007) 843-856
11. Mei S., Ho A.D., and Mahlknecht U. Role of histone inhibitors in the treatment of cancer. Int J Oncol 25 (2004) 1509-1519
12. Larsen L., Tonnesen M., Ronn S.G., Storling J., Jorgensen S., Mascagni P., et al. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia 50 (2007) 779-789
13. Tayaramma T., Ma B., Rohde M., and Mayer H. Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Stem Cells 24 (2006) 2858-2867
14. Kaiser C., and James S.R. Acetylation of insulin receptor substrat-1 is permissive for tyrosine phosphorylaton. BMC Biol 2 (2004) 23
15. Wang J., Zhai Q., Chen Y., Lin E., Gu W., McBurney M.W., et al. A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol 170 (2005) 349-355
16. 2-terminal kinase activation. Biochem Pharmacol 75 (2007) 1393-1401
17. Sun C., Zhang F., Ge X.J., Yan T.T., Chen X.M., Shi X.L., et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 6 (2007) 307-319
18. Lazar D.F., Wiese R.J., Brady M.J., Mastick C.C., Waters S.B., Yamauchi K., et al. Mitogen-activated protein kinase inhibition dose not block the stimulation of glucose utilization by insulin. J Biol Chem 270 (1995) 20801-20807
19. DeFronzo R.A., Jocot E., Jequier E., Wahren J., and Felber J.P. The effect of insulin on the disposal of intravenous glucose. Diabetes 30 (1981) 1000-1007
20. Yaspelkis B.B., Singh M.K., Krisan A.D., Collins D.E., Kwong C.C., Bermard J.R., et al. Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sci 74 (2004) 1801-1816
21. Doi M., Yamaoka I., Fukunaga T., and Nakayama M. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes. Biochem Biophys Res Commun 312 (2005) 1111-1117
22. Hoy A.J., Bruce C.R., Cederberg A., Tumer N., James D.E., Cooney G.J., et al. Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. Am J Physiol Endocrinol Metab 293 (2007) E1358-E1364
23. Doi M., Yamaoka I., Nakayama M., Mochizuki S., Sugahara K., and Yoshizawa F. Isoleucine, a blood glucose-lowering amino acid, increase glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr 135 (2005) 2103-2108
24. Kumar N., and Dey C.S. Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells. Biochem Pharmacol 65 (2003) 249-257
25. Bisht B., Goel H.L., and Dey C.S. Focal adhesion kinase regulates insulin resistance in skeletal muscle. Diabetologia 50 (2007) 1058-1069
26. Lo Y.T., Tzeng T.F., and Liu I.M. Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells. Horm Metab Res 39 (2007) 173-178
27. Chiasson J.L., and Rabasa-Lhoret R. Prevention of type 2 diabetes: insulin resistance and beta-cell function. Diabetes 53 (2004) S34-S38
28. Shulman R.G., Bloch G., and Rothman D.L. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proc Natl Acad Sci USA 92 (1995) 8535-8542
29. Jung S.H., Ha Y.J., Shim E.K., Choi S.Y., Jin J.L., Yun-Choi H.S., et al. Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. Biochem J 403 (2007) 243-250
30. Weigert C., Hennige A.M., Brodbeck K., Haring H.U., and Schleicher E.D. Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am J Physiol Endocrinol Metab 289 (2005) E251-E257
31. Roach P.J. Glycogen synthase and glycogen synthase kinases. Curr Top Cell Regul 20 (1981) 45-105
32. Sekhavat A., Sun J.M., and Davie J.R. Competitive inhibition of histone deacetylase activity by Trichostatin A and butyrate. Biochem Cell Biol 85 (2007) 751-758