ZNF23 induces apoptosis in human ovarian cancer cells

Cancer Letters

Volumn 266, Issue 2, 2008, Pages 135-143

  Huang, Chuanxin ^a   Yang, Shenglian ^a   Ge, Ruiliang ^b   Sun, Hongwei ^b   Shen, Feng ^b   Wang, Yizheng ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl XL; ZNF23

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; PROTEIN BCL XL; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 23;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL GROWTH; CELL NUCLEUS; CELL SURVIVAL; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION;

APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OVARIAN NEOPLASMS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 45049083955     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.02.059     Document Type: Article

References (21)

1. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
2. Abedini M.R., Qiu Q., Yan X., and Tsang B.K. Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro. Oncogene 23 (2004) 6997-7004
3. Wolf B.B., Schuler M., Li W., Eggers-Sedlet B., Lee W., Tailor P., Fitzgerald P., Mills G.B., and Green D.R. Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. J. Biol. Chem. 276 (2001) 34244-34251
4. Shayesteh L., Lu Y., Kuo W.L., Baldocchi R., Godfrey T., Collins C., Pinkel D., Powell B., Mills G.B., and Gray J.W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat. Genet. 21 (1999) 99-102
5. Schimmer A.D. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 64 (2004) 7183-7190
6. Ding H.F., and Fisher D.E. Induction of apoptosis in cancer: new therapeutic opportunities. Ann. Med. 34 (2002) 451-469
7. Urrutia R. KRAB-containing zinc-finger repressor proteins. Genome Biol. 4 (2003) 231
8. Tommerup N., and Vissing H. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27 (1995) 259-264
9. Huang C., Jia Y., Yang S., Chen B., Sun H., Shen F., and Wang Y. Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313 (2007) 254-263
10. Pervin S., Singh R., Gau C.L., Edamatsu H., Tamanoi F., and Chaudhuri G. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res. 61 (2001) 4701-4706
11. Opipari Jr. A.W., Tan L., Boitano A.E., Sorenson D.R., Aurora A., and Liu J.R. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res. 64 (2004) 696-703
12. Cossarizza A., Baccarani-Contri M., Kalashnikova G., and Franceschi C. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem. Biophys. Res. Commun. 197 (1993) 40-45
13. Heiskanen K.M., Bhat M.B., Wang H.W., Ma J., and Nieminen A.L. Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J. Biol. Chem. 274 (1999) 5654-5658
14. Zhu H., Guo W., Zhang L., Davis J.J., Teraishi F., Wu S., Cao X., Daniel J., Smythe W.R., and Fang B. Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells. Mol. Cancer Ther. 4 (2005) 451-456
15. Boatright K.M., and Salvesen G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15 (2003) 725-731
16. Adams J.M., and Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26 (2001) 61-66
17. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
18. Evan G.I., and Vousden K.H. Proliferation, cell cycle and apoptosis in cancer. Nature 411 (2001) 342-348
19. Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., and Thompson C.B. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74 (1993) 597-608
20. Danial N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
21. Shoemaker A.R., Oleksijew A., Bauch J., Belli B.A., Borre T., Bruncko M., Deckwirth T., Frost D.J., Jarvis K., Joseph M.K., Marsh K., McClellan W., Nellans H., Ng S., Nimmer P., O'Connor J.M., Oltersdorf T., Qing W., Shen W., Stavropoulos J., Tahir S.K., Wang B., Warner R., Zhang H., Fesik S.W., Rosenberg S.H., and Elmore S.W. A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res. 66 (2006) 8731-8739