Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions

Journal of the American Chemical Society

Volumn 130, Issue 23, 2008, Pages 7232-7234

  Sako, Yusuke ^a,b   Morimoto, Jumpei ^a,b   Murakami, Hiroshi ^a   Suga, Hiroaki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; TRANSFER RNA;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; CYCLOADDITION; DNA TEMPLATE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PEPTIDE SYNTHESIS; RIBOSOME;

ALANINE; ALKYNES; AMINO ACID SEQUENCE; AMINO ACIDS; AMINOBUTYRIC ACIDS; CODON; CYSTEINE; GLYCINE; PEPTIDES, CYCLIC; RIBOSOMES; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPLATES, GENETIC;

EID: 44949231370     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja800953c     Document Type: Article

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26. During the translation, the azide group of Aha, Anv, and Anl was very likely reduced by DTT and/or mercaptoethanol included in the translation buffer. See the following reference as an example of chemistry: Meinjohanns, E.; Meldal, M.; Jensen, T.; Werdelin, O.; GalliStampino, L.; Mouritsen, S.; Bock, K. J. Chem. Soc., Perkin Trans. 1 1997, 871-884.
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