Paternal contribution of HLA-G*0106 significantly increases risk for pre-eclampsia in multigravid pregnancies

Molecular Human Reproduction

Volumn 14, Issue 5, 2008, Pages 317-324

  Tan, Chia Yee ^a   Ho, Julia F V ^a   Chong, Yap Seng ^a   Loganath, Annamalai ^a   Chan, Yiong Huak ^a   Ravichandran, Jeganathan ^b   Lee, Caroline G ^a,c,d   Chong, Samuel S ^a,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b HOSPITAL SULTANAH AMINAH   (Malaysia)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Haplotype; HLA G; Placenta; Pre eclampsia; Pregnancy

Indexed keywords

HLA G ANTIGEN;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FETUS RISK; GENE FREQUENCY; GENE MAPPING; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALAYSIA; MULTIPLE PREGNANCY; MULTIPLEX POLYMERASE CHAIN REACTION; PREECLAMPSIA; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BASE SEQUENCE; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; FATHERS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GRAVIDITY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INFANT, NEWBORN; INHERITANCE PATTERNS; MALE; MATERNAL-FETAL EXCHANGE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS;

EID: 44949203413     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gan013     Document Type: Article

References (45)

1. Aldrich C, Verp MS, Walker MA, Ober C. A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation. J Reprod Immunol 2000;47:41-48.
2. Apps R, Gardner L, Sharkey AM, Holmes N, Moffett A. A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1. Eur J Immunol 2007;37 1924-1937.
3. Astin M, Scott JR, Worley RJ. Pre-eclampsia/eclampsia: A fatal father factor. Lancet 1981;2:533.
4. Bermingham J, Jenkins D, McCarthy T, O'Brien M. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochem Soc Trans 2000;28:215-219.
5. Campbell DM, MacGillivray I, Carr-Hill R. Pre-eclampsia in second pregnancy. Br J Obstet Gynaecol 1985;92:131-140.
6. Chesley LC, Annitto JE, Cosgrove RA. The familial factor in toxemia of pregnancy. Obstet Gynecol 1968;32:303-311.
7. Chumbley G, King A, Robertson K, Holmes N, Loke YW. Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 1994;155:312-322.
8. Cincotta RB, Brennecke SP. Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas. Int J Gynaecol Obstet 1998;60:23-27.
9. Clayton D. SNPHAP: A program for estimating frequencies of large haplotypes of SNPs (Version 1.3). 2002.
10. Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, McCluskey J. Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proc Natl Acad Sci USA 2005;102:3360-3365.
11. Colbern GT, Chiang MH, Main EK. Expression of the nonclassic histocompatibility antigen HLA-G by preeclamptic-placenta. Am J Obstet Gynecol 1994;170:1244-1250.
12. Dorling A, Monk NJ, Lechler RI. HLA-G inhibits the transendothelial migration of human NK cells. Eur J Immunol 2000;30:586-593.
13. Fons P, Chabot S, Cartwright JE, Lenfant F, L'Faqihi F, Giustiniani J, Herault JP, Gueguen G, Bono F, Savi P et al. Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells. Blood 2006; 108:2608-2615.
14. Fuzzi B, Rizzo R, Criscuoli L, Noci I, Melchiorri L, Scarselli B, Bencini E, Menicucci A, Baricordi OR. HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy. Eur J Immunol 2002;32:311-315.
15. Gerretsen G, Huisjes HJ, Elema JD. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol 1981;88:876-881.
16. Hackmon R, Koifman A, Hyobo H, Glickman H, Sheiner E, Geraghty DE. Reduced third-trimester levels of soluble human leukocyte antigen G protein in severe preeclampsia. Am J Obstet Gynecol 2007;197 255e1-255e5.
17. Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curer LB, Catalano PM, Morris CD. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol 2000;95:24-28.
18. Hnat MD, Sibai BM, Caritis S, Hauth J, Lindheimer MD, MacPherson C, VanDarsten JP, Landon M, Miodovnik M, Paul R et al. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol 2002; 186:422-426.
19. Humphrey KE, Harrison GA, Cooper DW, Wilton AN, Brennecke SP, Trudinger BJ. HLA-G deletion polymorphism and pre-eclampsia/eclampsia. Br J Obstet Gynaecol 1995;102:707-710.
20. Hunt JS, Pace JL, Morales PJ, Ober C. Immumogenicity of the soluble isoforms of HLA-G. Mol Hum Reprod 2003;9:729-735.
21. Hviid TV, Christiansen OB, Johansen JK, Hviid UR, Lundegaard C, Moller C, Morling N. Characterization of a new HLA-G allele encoding a nonconservative amino acid substitution in the alpha3 domain (exon 4) and its relevance to certain complications in pregnancy. Immunogenetics 2001;53:48-53.
22. Hylenius S, Andersen AM, Melbye M, Hviid TV. Association between HLA-G genotype and risk of pre-eclampsia: A case-control study using family triads. Mol Hum Reprod 2004;10:237-246.
23. King A, Boocock C, Sharkey AM, Gardner L, Beretta A, Siccardi AG, Loke YW. Evidence for the expression of HLAA-C class I mRNA and protein by human first trimester trophoblast. J Immunol 1996;156 2068-2076.
24. Le Bouteiller P, Legrand-Abravanel F, Solier C. Soluble HLA-G1 at the matemo-foetal interface - a review. Placenta 2003a;24(Suppl A):S10-S15.
25. Le Bouteiller P, Pizzato N, Barakonyi A, Solier C. HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol 2003b;59 219-234.
26. Le Bouteiller P, Fons P, Herault JP, Bono F, Chabot S, Cartwright JE, Bensussan A. Soluble HLA-G and control of angiogenesis. J Reprod Immunol 2007;76:17-22.
27. Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A et al. Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 2001;86:1823-1834.
28. Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM. Fetal and maternal contributions to risk of pre-eclampsia: Population based study. BMJ 1998;316:1343-1347.
29. Lin A, Yan WH, Dai MZ, Chen XJ, Li BL, Chen BG, Fan LA. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens 2006;68:311-316.
30. Livingston JC, Maxwell BD. Preeclampsia: Theories and speculations. Wien Klin Wochenschr 2003;115:145-148.
31. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning, A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
32. Ness RB, Roberts JM. Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications. Am J Obstet Gynecol 1996;175:1365-1370.
33. O'Brien M, McCarthy T, Jenkins D, Paul P, Dausset J, Carosella ED, Moreau P. Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: Possible role of the HLA-G gene in susceptibility to the disease. Cell Mol Life Sci 2001;58 1943-1949.
34. Ober C, Aldrich C, Rosinsky B, Robertson A, Walker MA, Willadsen S, Verp MS, Geraghty DE, Hunt JS. HLA-G1 protein expression is not essential for fetal survival. Placenta 1998;19:127-132.
35. Robillard PY, Hulsey TC, Perianin J, Janky E, Miri EH, Papiernik E. Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception. Lancet 1994;344:973-975.
36. Rousseau P, Le Discorde M, Mouillot G, Marcou C, Carosella ED, Moreau P. The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol 2003;64 1005-1010.
37. Saftlas AF, Levine RJ, Klebanoff MA, Martz KL, Ewell MG, Morris CD, Sibai BM. Abortion, changed paternity, and risk of preeclampsia in nulliparous women. Am J Epidemiol 2003;157:1108-1114.
38. Shiroishi M, Kuroki K, Ose T, Rasubala L, Shiratori I, Arase H, Tsumoto K, Kumagai I, Kohda D, Maenaka K. Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. J Biol Chem 2006a;281:10439-10447.
39. Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K. Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Proc Natl Acad Sci USA 2006b;103 16412-16417.
40. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003;102:181-192.
41. Smith GN, Walker M, Tessier JL, Millar KG. Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol 1997;177:455-458.
42. Trupin LS, Simon LP, Eskenazi B. Change in paternity: A risk factor for preeclampsia in multiparas. Epidemiology 1996;7:240-244.
43. Wang JX, Knottnerus AM, Schuit G, Norman RJ, Chan A, Dekker GA. Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia. Lancet 2002;359:673-674.
44. Yie SM, Li LH, Li YM, Librach C. HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia. Am J Obstet Gynecol 2004;191:525-529.
45. Yie SM, Balakier H, Motamedi G, Librach CL. Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate. Fertil Steril 2005;83:30-36.