Caspase-3 gene transfected with LIGHT gene: Can it be used for therapy of human hepatocellular carcinoma?

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 4, 2008, Pages 470-474

  Lu, Yun ^a   Wu, Li Qun ^a   Wang, Shou Guang ^a   Lv, Zhen Hua ^a   Han, Bing ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Caspase 3; Hepatocellular carcinoma; HepG2 cell; LIGHT gene; Transfection

Indexed keywords

CASPASE 3; LIPOSOME;

ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGHT GENE; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN SECRETION;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENETIC TECHNIQUES; HUMANS; LIVER NEOPLASMS; MODELS, GENETIC; PLASMIDS; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14;

ESCHERICHIA COLI;

EID: 44949200384     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.094     Document Type: Article

References (23)

1. Michielsen PP, Francque SM, van Dongen JL. Viral hepatitis and hepatocellular carcinoma. World J Surg Oncol 2005;3:27.
2. Volbracht C, Leist M, Kolb SA, Nicotera P. Apoptosis in caspase-inhibited neurons. Mol Med 2001;7:36-48.
3. Weber GF, Menko AS. The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation. J Biol Chem 2005;280:22135-45.
4. Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, et al. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 2004;11:550-63.
5. Chen JC, Lu KW, Lee JH, Yeh CC, Chung JG. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res 2006;26:4313-26.
6. Kondoh Y, Kawada T, Urade R. Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1). Biochim Biophys Acta 2007;1771:500-5.
7. Singh SV, Zeng Y, Xiao D, Vogel VG, Nelson JB, Dhir R, et al. Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol Cancer Ther 2005;4:1747-54.
8. Malet G, Martin AG, Orzaez M, Vicent MJ, Masip I, Sanclimens G, et al. Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis. Cell Death Differ 2006;13:1523-32.
9. Atapattu DN, Czuprynski CJ. Mannheimia haemolytica leukotoxin induces apoptosis of bovine lymphoblastoid cells (BL-3) via a caspase-9-dependent mitochondrial pathway. Infect Immun 2005;73:5504-13.
10. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996;85:817-27.
11. Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem 1998;273:7783-6.
12. Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell 1999;96:615-24.
13. Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC. LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochem Biophys Res Commun 2007;359:379-84.
14. Chen MC, Hsu TL, Luh TY, Hsieh SL. Overexpression of bcl-2 enhances LIGHT- and interferon-gamma-mediated apoptosis in Hep3BT2 cells. J Biol Chem 2000;275:38794-801.
15. Brick DJ, Burke RD, Minkley AA, Upton C. Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis. J Gen Virol 2000;81:1087-97.
16. Matsui H, Hikichi Y, Tsuji I, Yamada T, Shintani Y. LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. J Biol Chem 2002;277:50054-61.
17. Danbara N, Yuri T, Tsujita-Kyutoku M, Tsukamoto R, Uehara N, Tsubura A. Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. Anticancer Res 2005;25:2269-76.
18. Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, et al. Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. Exp Mol Med 2005;37:276-81.
19. Yang LJ, Wang WL. Preparation of monoclonal antibody against apoptosis-associated antigens of hepatoma cells by subtractive immunization. World J Gastroenterol 2002;8:808-14.
20. Peng YC, Kuo HS, Tsai HD, Yang YP, Lin YL. The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2. Bioorg Med Chem 2006;14:263-72.
21. Baltzer A, Svanborg C, Jaggi R. Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin. Cell Mol Life Sci 2004;61:1221-8.
22. Pettmann B, Henderson CE. Neuronal cell death. Neuron. 1998;20:633-47.
23. Nuñez G, Benedict MA, Hu Y, Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene 1998;17:3237-45.