Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis: Implications on reflectance-based diagnosis of epithelial precancer

Journal of Biomedical Optics

Volumn 13, Issue 3, 2008, Pages

  Kortun, Cemre ^a   Hijazi, Yasser R ^b   Arifler, Dizem ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b EASTERN MEDITERRANEAN UNIVERSITY   (Turkey)

Author keywords

epithelial precancer; fiber optic probes; finite difference time domain modeling; Monte Carlo modeling; phase function; reflectance spectroscopy

Indexed keywords

EPITHELIAL PRECANCER; FIBER OPTIC PROBES; FINITE-DIFFERENCE TIME-DOMAIN MODELING; MONTE CARLO MODELING; PHASE FUNCTIONS; REFLECTANCE SPECTROSCOPY;

FINITE DIFFERENCE TIME DOMAIN METHOD; HISTOLOGY; MONTE CARLO METHODS; OPTICAL PROPERTIES; PHOTONS; PROBES; REFLECTION; SCATTERING; SPECTROSCOPY; TISSUE;

TIME DOMAIN ANALYSIS;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; HUMAN; METHODOLOGY; MONTE CARLO METHOD; NEOPLASM; PHOTOMETRY; PHOTON; PRECANCER; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ALGORITHMS; COMPUTER SIMULATION; DIAGNOSIS, COMPUTER-ASSISTED; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; NEOPLASMS, GLANDULAR AND EPITHELIAL; PHOTOMETRY; PHOTONS; PRECANCEROUS CONDITIONS; SENSITIVITY AND SPECIFICITY;

EID: 44949184059     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.2939405     Document Type: Article

References (52)

1. R., Drezek, K., Sokolov, U., Utzinger, I., Boiko, A., Malpica, M., Follen, and R., Richards-Kortum, " Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications, ", J. Biomed. Opt., 6 (4), 385-396 (2001). jbo JBOPFO 1083-3668 10.1117/1.1413209
2. I. V., Meglinski and S. J., Matcher, " Computer simulation of the skin reflectance spectra, ", Comput. Methods Programs Biomed., 70, 179-186 (2003). cmb CMPBEX 0169-2607 10.1016/S0169-2607(02)00099-8
3. D., Hidovic-Rowe and E., Claridge, " Modelling and validation of spectral reflectance for the colon, ", Phys. Med. Biol., 50, 1071-1093 (2005). pme PHMBA7 0031-9155 10.1088/0031-9155/50/6/003
4. J., Swartling, J., Svensson, D., Bengtsson, K., Terike, and S., Andersson-Engels, " Fluorescence spectra provide information on the depth of fluorescent lesions in tissue, ", Appl. Opt., 44, 1934-1941 (2005). apo APOPAI 0003-6935 10.1364/AO.44.001934
5. D., Arifler, C., MacAulay, M., Follen, and R., Richards-Kortum, " Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements, ", J. Biomed. Opt., 11, 064027 (2006). jbo JBOPFO 1083-3668 10.1117/1.2398932
6. T. J., Pfefer, K. T., Schomacker, M. N., Ediger, and N. S., Nishioka, " Light propagation in tissue during fluorescence spectroscopy with single-fiber probes, ", IEEE J. Sel. Top. Quantum Electron., 7, 1004-1012 (2001). isq IJSQEN 1077-260X 10.1109/2944.983306
7. T. J., Pfefer, K. T., Schomacker, M. N., Ediger, and N. S., Nishioka, " Multiple-fiber probe design for fluorescence spectroscopy in tissue, ", Appl. Opt., 41, 4712-4721 (2002). apo APOPAI 0003-6935 10.1364/AO.41.004712
8. C., Zhu, Q., Liu, and N., Ramanujam, " Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: a Monte Carlo simulation, ", J. Biomed. Opt., 8 (2), 237-247 (2003). jbo JBOPFO 1083-3668 10.1117/1.1559058
9. M. C., Skala, G. M., Palmer, C., Zhu, Q., Liu, K. M., Vrotsos, C. L., Marshek-Stone, A., Gendron-Fitzpatrick, and N., Ramanujam, " Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers, ", Lasers Surg. Med., 34, 25-38 (2004). lsm LSMEDI 0196-8092 10.1002/lsm.10239
10. D., Arifler, R. A., Schwarz, S. K., Chang, and R., Richards-Kortum, " Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and stroma, ", Appl. Opt., 44, 4291-4305 (2005). apo APOPAI 0003-6935 10.1364/AO.44.004291
11. T. J., Pfefer, A., Agrawal, and R. A., Drezek, " Oblique-incidence illumination and collection for depth-selective fluorescence spectroscopy, ", J. Biomed. Opt., 10, 044016 (2005). jbo JBOPFO 1083-3668 10.1117/1.1989308
12. A. M. J., Wang, J. E., Bender, J., Pfefer, U., Utzinger, and R. A., Drezek, " Depth-sensitive reflectance measurements using obliquely oriented fiber probes, ", J. Biomed. Opt., 10, 044017 (2005). jbo JBOPFO 1083-3668 10.1117/1.1989335
13. C., Zhu, G. M., Palmer, T. M., Breslin, F., Xu, and N., Ramanujam, " Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer, ", J. Biomed. Opt., 10, 024032 (2005). jbo JBOPFO 1083-3668 10.1117/1.1897398
14. A., Wang, V., Nammalavar, and R., Drezek, " Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations, ", J. Biomed. Opt., 12, 044012 (2007). jbo JBOPFO 1083-3668 10.1117/1.2769328
15. L., Wang, S. L., Jacques, and L., Zheng, " MCML - Monte Carlo modeling of light transport in multi-layered tissues, ", Comput. Methods Programs Biomed., 47, 131-146 (1995). cmb CMPBEX 0169-2607 10.1016/0169-2607(95) 01640-F
16. F., Bevilacqua and C., Depeursinge, " Monte Carlo study of diffuse reflectance at source-detector separations close to one transport mean free path, ", J. Opt. Soc. Am. A, 16, 2935-2945 (1999). joa JOAOD6 0740-3232
17. A., Kienle, F. K., Forster, and R., Hibst, " Influence of the phase function on determination of the optical properties of biological tissue by spatially resolved reflectance, ", Opt. Lett., 26, 1571-1573 (2001). opl OPLEDP 0146-9592 10.1364/OL.26.001571
18. H., Tian, Y., Liu, and L., Wang, " Influence of the third-order parameter on diffuse reflectance at small source-detector separations, ", Opt. Lett., 31, 933-935 (2006). opl OPLEDP 0146-9592
19. J. R., Mourant, J., Boyer, A. H., Hielscher, and I. J., Bigio, " Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations, ", Opt. Lett., 21, 546-548 (1996). opl OPLEDP 0146-9592
20. M., Canpolat and J. R., Mourant, " High-angle scattering events strongly affect light collection in clinically relevant measurement geometries for light transport through tissue, ", Phys. Med. Biol., 45, 1127-1140 (2000). pme PHMBA7 0031-9155 10.1088/0031-9155/45/5/304
21. A., Taflove and S. C., Hagness, Computational Electrodynamics: The Finite-Difference Time-Domain Method, Artech House, Norwood, MA (2005).
22. A., Dunn and R., Richards-Kortum, " Three-dimensional computation of light scattering from cells, ", IEEE J. Sel. Top. Quantum Electron., 2, 898-905 (1996). isq IJSQEN 1077-260X 10.1109/2944.577313
23. R., Drezek, A., Dunn, and R., Richards-Kortum, " Light scattering from cells: finite-difference time-domain simulations and goniometric measurements, ", Appl. Opt., 38, 3651-3661 (1999). apo APOPAI 0003-6935 10.1364/AO.38.003651
24. R., Drezek, A., Dunn, and R., Richards-Kortum, " A pulsed finite-difference time-domain (FDTD) method for calculating light scattering from biological cells over broad wavelength ranges, ", Opt. Express, 6, 147-157 (2000). 8mi OPEXFF 1094-4087
25. N. N., Boustany, R., Drezek, and N. V., Thakor, " Calcium-induced alterations in mitochondrial morphology quantified in situ with optical scatter imaging, ", Biophys. J., 83, 1691-1700 (2002). bio BIOJAU 0006-3495
26. R., Drezek, M., Guillaud, T., Collier, I., Boiko, A., Malpica, C., MacAulay, M., Follen, and R., Richards-Kortum, " Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture, ", J. Biomed. Opt., 8 (1), 7-16 (2003). jbo JBOPFO 1083-3668 10.1117/1.1528950
27. D., Arifler, M., Guillaud, A., Carraro, A., Malpica, M., Follen, and R., Richards-Kortum, " Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition, ", J. Biomed. Opt., 8 (3), 484-494 (2003). jbo JBOPFO 1083-3668 10.1117/1.1578640
28. J., He, A., Karlsson, J., Swartling, and S., Andersson-Engels, " Light scattering by multiple red blood cells, ", J. Opt. Soc. Am. A, 21, 1953-1961 (2004). joa JOAOD6 0740-3232
29. C., Liu, C., Capjack, and W., Rozmus, " 3-D simulation of light scattering from biological cells and cell differentiation, ", J. Biomed. Opt., 10, 014007 (2005). jbo JBOPFO 1083-3668 10.1117/1.1854681
30. X., Li, A., Taflove, and V., Backman, " Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures, ", IEEE J. Sel. Top. Quantum Electron., 11, 759-765 (2005). isq IJSQEN 1077-260X 10.1109/JSTQE.2005.857691
31. R. S., Brock, X., Hu, D. A., Weidner, J., Mourant, and J. Q., Lu, " Effect of detailed cell structure on light scattering distribution: FDTD study of a B-cell with 3D structure constructed from confocal images, ", J. Quant. Spectrosc. Radiat. Transf., 102, 25-36 (2006). jqs JQSRAE 0022-4073 10.1016/j.jqsrt.2006.02.075
32. L. G., Koss, Diagnostic Cytology and Its Histopathologic Bases, Lippincott, Philadelphia, PA (1992).
33. U., Utzinger and R., Richards-Kortum, " Fiber optic probes for biomedical optical spectroscopy, ", J. Biomed. Opt., 8 (1), 121-147 (2003). jbo JBOPFO 1083-3668 10.1117/1.1528207
34. L., Nieman, A., Myakov, J., Aaron, and K., Sokolov, " Optical sectioning using a fiber probe with an angled illumination-collection geometry: evaluation in engineered tissue phantoms, ", Appl. Opt., 43, 1308-1319 (2004). apo APOPAI 0003-6935 10.1364/AO.43.001308
35. A., Wang, V., Nammalavar, and R., Drezek, " Experimental evaluation of angularly variable fiber geometry for targeting depth-resolved reflectance from layered epithelial tissue phantoms, ", J. Biomed. Opt., 12, 044011 (2007). jbo JBOPFO 1083-3668 10.1117/1.2769331
36. J. R., Mourant, T. J., Bocklage, T. M., Powers, H. M., Greene, K. L., Bullock, L. R., Marr-Lyon, M. H., Dorin, A. G., Waxman, M. M., Zsemlye, and H. O., Smith, " In vivo, light scattering measurements for detection of precancerous conditions of the cervix, ", Gynecol. Oncol., 105, 439-445 (2007). 4t4 GYNOA3 0090-8258
37. T., Binzoni, T. S., Leung, A. H., Gandjbakhche, D., Rüfenacht, and D. T., Delpy, " Comment on 'The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics', ", Phys. Med. Biol., 51, L39-L41 (2006). pme PHMBA7 0031-9155
38. J., Banks, J. S., Carson, II, B. L., Nelson, and D. M., Nicol, Discrete-Event System Simulation, Pearson Prentice Hall, Englewood Cliffs, NJ (2005).
39. P., Thueler, I., Charvet, F., Bevilacqua, M. St., Ghislain, G., Ory, P., Marquet, P., Meda, B., Vermeulen, and C., Depeursinge, " In vivo, endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties, ", J. Biomed. Opt., 8 (3), 495-503 (2003). jbo JBOPFO 1083-3668 10.1117/1.1578494
40. E., Berrocal, D. L., Sedarsky, M. E., Paciaroni, I. V., Meglinski, and M. A., Linne, " Laser light scattering in turbid media - Part I: Experimental and simulated results for the spatial intensity distribution, ", Opt. Express, 15, 10649-10665 (2007). 8mi OPEXFF 1094-4087 10.1364/OE.15.010649
41. J. M., Schmitt and G., Kumar, " Turbulent nature of refractive-index variations in biological tissue, ", Opt. Lett., 21, 1310-1312 (1996). opl OPLEDP 0146-9592
42. H., Fang, M., Ollero, E., Vitkin, L. M., Kimerer, P. B., Cipolloni, M. M., Zaman, S. D., Freedman, I. J., Bigio, I., Itzkan, E. B., Hanlon, and L. T., Perelman, " Noninvasive sizing of subcellular organelles with light scattering spectroscopy, ", IEEE J. Sel. Top. Quantum Electron., 9, 267-276 (2003). isq IJSQEN 1077-260X 10.1109/JSTQE.2003.812515
43. J. D., Wilson, C. E., Bigelow, D. J., Calkins, and T. H., Foster, " Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling, ", Biophys. J., 88, 2929-2938 (2005). bio BIOJAU 0006-3495 10.1529/biophysj.104.054528
44. M., Xu and R. R., Alfano, " Fractal mechanisms of light scattering in biological tissue and cells, ", Opt. Lett., 30, 3051-3053 (2005). opl OPLEDP 0146-9592 10.1364/OL.30.003051
45. B., Beauvoit, T., Kitai, and B., Chance, " Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach, ", Biophys. J., 67, 2501-2510 (1994). bio BIOJAU 0006-3495
46. J. D., Wilson, W. J., Cottrell, and T. H., Foster, " Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes, ", J. Biomed. Opt., 12, 014010 (2007). jbo JBOPFO 1083-3668 10.1117/1.2437765
47. D. C., Walker, B. H., Brown, A. D., Blackett, J., Tidy, and R. H., Smallwood, " A study of the morphological parameters of cervical squamous epithelium, ", Physiol. Meas, 24, 121-135 (2003). 3nk ZZZZZZ 0967-3334
48. S. T., Flock, B. C., Wilson, and M. S., Patterson, " Total attenuation coefficients and phase functions of tissues and phantom materials at, 633nm, ", Med. Phys., 14, 835-841 (1987). mph MPHYA6 0094-2405 10.1118/1.596010
49. J. R., Mourant, T. M., Johnson, V., Doddi, and J. P., Freyer, " Angular dependent light scattering from multicellular spheroids, ", J. Biomed. Opt., 7 (1), 93-99 (2002). jbo JBOPFO 1083-3668 10.1117/1.1427053
50. M. I., Mishchenko, L., Liu, D. W., Mackowski, B., Cairns, and G., Videen, " Multiple scattering by random particulate media: exact 3D results, ", Opt. Express, 15, 2822-2836 (2007). 8mi OPEXFF 1094-4087 10.1364/OE.15.002822
51. J., Ramachandran, T. M., Powers, S., Carpenter, A., Garcia-Lopez, J. P., Freyer, and J. R., Mourant, " Light scattering and microarchitectural differences between tumorigenic and non-tumorigenic cell models of tissue, ", Opt. Express, 15, 4039-4053 (2007). 8mi OPEXFF 1094-4087 10.1364/OE.15.004039
52. D., Arifler, I., Pavlova, A., Gillenwater, and R., Richards-Kortum, " Light scattering from collagen fiber networks: micro-optical properties of normal and neoplastic stroma, ", Biophys. J., 92, 3260-3274 (2007). bio BIOJAU 0006-3495