Experimental evaluation of angularly variable fiber geometry for targeting depth-resolved reflectance from layered epithelial tissue phantoms

Journal of Biomedical Optics

Volumn 12, Issue 4, 2007, Pages

  Wang, Adrien ^a   Nammalavar, Vengadesan ^a   Drezek, Rebekah ^a  

^a Rice University   (United States)

Author keywords

Epithelial dysplasia; Fiber optic probes; Phantom; Reflectance spectroscopy

Indexed keywords

FIBER OPTICS; GEOMETRY; MORPHOLOGY; OPTICAL PROPERTIES; REFLECTION; TISSUE;

EPITHELIAL DYSPLASIA; REFLECTANCE SPECTROSCOPY;

BIOMEDICAL ENGINEERING;

ANISOTROPY; ARTICLE; CYTOLOGY; EPITHELIUM; EVALUATION; FEMALE; HUMAN; IMAGE QUALITY; INSTRUMENTATION; METHODOLOGY; PHOTOMETRY; PHYSIOLOGY; SPECTROFLUOROMETRY; ULTRASTRUCTURE; UTERINE CERVIX;

ANISOTROPY; CERVIX UTERI; EPITHELIUM; FEMALE; HUMANS; PHANTOMS, IMAGING; PHOTOMETRY; SPECTROMETRY, FLUORESCENCE;

EID: 35948991491     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.2769331     Document Type: Article

References (39)

1. I. Bigio and J. R. Mourant, "Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy," Phys. Med. Biol. 42, 803-814 (1997). (Pubitemid 27263501)
2. K. Sokolov, R. Drezek, K. Gossage, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology," Opt. Express 5 (13), 302-317 (1999).
3. R. Drezek, R. Richards-Kortum, M. Brewer, M. Feld, C. Pitris, A. Ferenczy, M. Faupel, and M. Follen, "Optical imaging of the cervix," 2nd Intl. Conf. Cervical Cancer, pp. 2015-2027 (2003). (Pubitemid 37310210)
4. A. Wax, J. W. Pythila, R. N. Graf, R. Nines, C. W. Boone, R. R. Dasari, M. S. Feld, V. E. Steele, and G. D. Stoner, "Prospective grading of neoplastic change in rat esophagus epithelium using angleresolved low-coherence interferometry," J. Biomed. Opt. 10 (5), 051604 (2005).
5. J. Mourant, T. Fuselier, J. Boyer, T. Johnson, and I. Bigio, "Prediction and measurements of scattering and absorption over broad wavelength range in tissue phantoms," Appl. Opt. 36, 949-957 (1997). (Pubitemid 127638552)
6. S. Avrillier, E. Tinet, D. Ettori, J. Tualle, and B. Gelebart, "Influence of emission-reception geometry in laser-induced fluorescence spectra from turbid media," Appl. Opt. 37, 2781-2787 (1998). (Pubitemid 128657590)
7. G. Kumar and J. Schmitt, "Optimal probe geometry for near-infrared spectroscopy of biological tissue," Appl. Opt. 36, 2286-2293 (1997). (Pubitemid 127625418)
8. T. J. Pfefer, L. Matchette, and R. Drezek, "Influence of illumination collection geometry on fluorescence spectroscopy in multi-layered tissue," Med. Biol. Eng. Comput. 42, 669-673 (2004). (Pubitemid 39386948)
9. T. J. Pfefer, K. Schomacker, M. Ediger, and N. Nishioka, "Multiple fiber probe design for fluorescence spectroscopy in tissue," Appl. Opt. 41, 4712-4720 (2002).
10. C. Zhu, Q. Liu, and N. Ramanujam, "Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: a Monte Carlo simulation," J. Biomed. Opt. 8 (2), 237-247 (2003).
11. T. J. Pfefer, L. Matchette, A. Ross, and M. Ediger, "Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design," Opt. Lett. 28, 120-122 (2003).
12. L. Quan and N. Ramanujam, "Relationship between depth of a target in a turbid medium and fluorescence measured by a variable-aperture method," Opt. Lett. 27, 102-106 (2002).
13. J. Mourant, J. Boyer, A. Hielscher, and I. Bigio, "Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations," Opt. Lett. 21, 546-548 (1996). (Pubitemid 126572793)
14. T. Papaioannou, N. Preyer, Q. Fang, A. Brightwell, M. Carnohan, G. Cottone, R. Ross, L. Jones, and L. Marcu, "Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media, an experimental and computational study at 337 nm," Appl. Opt. 43, 2846-2860 (2004).
15. D. Arifler, R. Schwarz, S. Chang, and R. Richards-Kortum, "Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and stroma," Appl. Opt. 44(20), 4291-305 (2005). (Pubitemid 41048351)
16. L. Nieman, A. Myakov, J. Aaron, and K. Sokolov, "Optical sectioning using a fiber probe with an angled illumination-collection geometry: evaluation in engineered tissue phantoms," Appl. Opt. 43(6), 1308-1319 (2004).
17. A. Wang, J. Bender, J. Pfefer, U. Utzinger, and R. A. Drezek, "Depth-sensitive reflectance measurements using obliquely oriented fiber probes," J. Biomed. Opt. 10(4), 044017 (2005).
18. M. Skala, G. Palmer, C. Zhu, Q. Liu, K. Vrotsos, C. Marshek-Stone, A. Gendron-Fitzpatrick, and N. Ramanujam, "Investigation of fiberoptic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers," Lasers Surg. Med. 34, 25-38 (2004). (Pubitemid 38101757)
19. C. K. Brookner, M. Follen, I. Boiko, J. Galvan, S. Thomsen, A. Malpica, S. Suzuki, R. Lota, and R. Richards-Kortum, "Autofluorescence patterns in short-term cultures of normal cervical tissue," Photochem. Photobiol. 71, 730-736 (2000).
20. C. Sato, M. Shimada, Y. Yamada, and Y. Hoshi, "Extraction of depthdependent signals from time-resolved reflectance in layered turbid media," J. Biomed. Opt. 10(6), 064008 (2005).
21. T. Collier, P. Shen, B. de Pradier, K. B. Sung, and R. Richards-Kortum, "Near real time confocal microscopy of amelanotic tissue: dynamics of aceto-whitening enable nuclear segmentation," Opt. Express 6(2), 40-48 (2000).
22. S. Chang, D. Arifler, R. Drezek, M. Follen, and R. Richards-Kortum, "Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements," J. Biomed. Opt. 9(3), 511-522 (2004).
23. G. Palmer and N. Ramanujam, "A Monte Carlo based inverse model for calculating tissue optical properties, part I: Theory and validation on synthetic phantoms," Appl. Opt. 45(5), 1062-1071 (2006).
24. K. Gossage, C. Smith, E. Kanter, L. Hariri, A. Stone, J. Rodriguez, S. Williams, and J. Barton, "Texture analysis of speckle in optical coherence tomography images of tissue phantoms," Phys. Med. Biol. 51, 1563-1575 (2006). (Pubitemid 43332355)
25. V. Backman, V. Gopal, M. Kalashnikov, K. Badizadegan, R. Gurjar, A. Wax, I. Georgakoudi, M. Mueller, C. Boone, R. Dasari, and M. Feld, "Measuring cellular structure at submicrometer scale with light scattering spectroscopy," IEEE J. Quantum Electron. 7(6), 887-893 (2001). (Pubitemid 34191804)
26. V. Backman, M. Wallace, L. Perelman, J. Arendt, R. Gurjar, M. Muller, Q. Zhang, G. Zonios, E. Kline, T. McGillican, S. Shapshay, T. Valdez, K. Badizadegan, J. Crawford, M. Fitzmaurice, S. Kabani, H. Levin, M. Seiler, R. Dasari, I. Itzkan, J. Van Dam, and M. Feld, "Detection of preinvasive cancer cells," Nature (London) 406, 35-36 (2000). (Pubitemid 30460198)
27. V. Backman, R. Gurjar, K. Badizadegan, I. Itzkan, R. Dasari, L. Perelman, and M. Feld, "Polarized light scattering spectroscopy for quantitative measurements of epithelial cellular structures in situ," IEEE J. Quantum Electron. 5, 1019-1026 (1999). (Pubitemid 30544900)
28. R. Gurjar, V. Backman, L. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. Dasari, and M. Feld, "Imaging human epithelial properties with polarized light-scattering spectroscopy," Nat. Med. 7(11), 1245-1248 (2001). (Pubitemid 33063781)
29. K. J. Heppner, L. M. Matrisian, R. A. Jensen, and W. H. Rodgers, "Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response," Am. J. Pathol. 149, 273-282 (1996). (Pubitemid 26230998)
30. W. C. Parks, Matrix Metalloproteinases Academic, San Diego, CA (1998).
31. I. Pavlova, K. Sokolov, R. Drezek, A. Malpica, M. Follen, and R. Richards-Kortum, "Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy," Photochem. Photobiol. 77, 550-555 (2003).
32. I. Georgakoudi, E. Sheets, M. Müller, V. Backman, C. Crum, K. Badizadegan, R. Dasari, and M. Feld, "Trimodal spectroscopy for the detection and characterization of cervical percancers in vivo," Am. J. Obstet. Gynecol. 186, 374-382 (2002). (Pubitemid 34234144)
33. M. Müller, T. Valdez, I. Georgakoudi, V. Backman, C. Fuentes, S. Kabani, N. Laver, Z. Wang, C. Boone, R. Dasari, S. Shapshay, and M. Feld, "Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma," Cancer 97, 1681-1692 (2003). (Pubitemid 36350711)
34. A. Amelink, M. Bard, S. Burgers, and T. Sterenborg, " Singlescattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media," Appl. Opt. 42(19), 4095-4101 (2003).
35. A. Amelink and T. Sterenborg, "Measurement of the local optical properties of turbid media by differential path-length spectroscopy," Appl. Opt. 43(15), 3048-3054 (2004).
36. D. Arifler, C. MacAulay, M. Follen, and R. Richards-Kortum, "Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements," J. Biomed. Opt. 11(6), 064027 (2006).
37. Q. Liu and N. Ramanujam, "Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media," Opt. Lett. 29(17), 2034-2036 (2004).
38. R. Schwarz, D. Arifler, S. Chang, I. Pavlova, I. Hussain, V. Mack, B. Knight, R. Richards-Kortum, and A. Gillenwater, "Ball lens coupled fiber-optic probe for depth resolved spectroscopy of epithelial tissue," Opt. Lett. 30(10), 1159-1161 (2005). (Pubitemid 40795093)
39. A. Wang, V. Nammalvar, and R. Drezek, "Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations," J. Biomed. Opt. 12, 044013 (2007).