Investigation of Fiber-Optic Probe Designs for Optical Spectroscopic Diagnosis of Epithelial Pre-Cancers

Lasers in Surgery and Medicine

Volumn 34, Issue 1, 2004, Pages 25-38

  Skala, Melissa C ^a   Palmer, Gregory M ^a   Zhu, Changfang ^a   Liu, Quan ^a   Vrotsos, Kristin M ^a   Marshek Stone, Crystal L ^a   Gendron Fitzpatrick, Annette ^b   Ramanujam, Nirmala ^a  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Diffuse reflectance; Dysplasia; Epithelium; Fiber optic; Fluorescence; Hamster; In vivo; Monte Carlo; Pre cancer; Spectroscopy

Indexed keywords

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEEK POUCH; CONTROLLED STUDY; DIFFUSE REFLECTANCE SPECTROSCOPY; EPITHELIUM DYSPLASIA; EPITHELIUM PRECANCER; FIBER OPTICS; FLUORESCENCE SPECTROSCOPY; HAMSTER; ILLUMINATION; IN VIVO STUDY; INSTRUMENTATION; MALE; MONTE CARLO METHOD; NONHUMAN; OPTICAL SPECTROSCOPY; PRECANCER; PRIORITY JOURNAL; SPECTROSCOPY; SQUAMOUS EPITHELIUM;

ALGORITHMS; ANIMALS; CRICETINAE; EPITHELIUM; EQUIPMENT DESIGN; FIBER OPTICS; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, FLUORESCENCE;

EID: 0346502257     PISSN: 01968092     EISSN: None     Source Type: Journal    
DOI: 10.1002/lsm.10239     Document Type: Article

References (38)

1. Pfefer TJ, Matchette LS, Ross AM, Ediger MN. Selective detection of fluorophore layers in turbid media: The role of fiber-optic probe design. Opt Lett 2003;28(2):120-122.
2. Ramanujam N. Fluorescence spectroscopy of neoplastic and non-neoplastic tissues. Neoplasia 2000;2(1-2):89-117.
3. Ramanujam N. Fluorescence spectroscopy in vivo. In: Meyers R, editor. Encyclopedia of analytical chemistry. Chichester: John Wiley & Sons Ltd. 2000:20-56.
4. Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, Richards-Kortum R. Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia. Photochem Photobiol 2001;73(6):636-641.
5. Pavlova I, Sokolov K, Drezek R, Malpica A, Follen M, Richards-Kortum R. Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy. Photochem Photobiol 2003;77(5):550-555.
6. Ramanujam N, Kortum RR, Thomsen S, Jansen AM, Follen M, Chance B. Low temperature fluorescence imaging of freeze-trapped human cervical tissues. Opt Exp 2001;8:335-343.
7. Gill EM, Malpica A, Alford RE, Nath AR, Follen M, Richards-Kortum RR, Ramanujam N. Relationship between collagen autofluorescence of the human cervix and menopausal status. Photochem Photobiol 2003;77(6):653-658.
8. Brookner CK, Follen M, Boiko I, Galvan J, Thomsen S, Malpica A, Suzuki S, Lotan R, Richards-Kortum R. Autofluorescence patterns in short-term cultures of normal cervical tissue. Photochem Photobiol 2000;71(6):730-736.
9. Utzinger U, Richards-Kortum RR. Fiber optic probes for biomedical optical spectroscopy. J Biomed Opt 2003;8(1): 121-147.
10. Keijzer M, Richards-Kortum R, Jacques S, Feld MS. Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta. Appl Opt 1989;28(20):4286-4292.
11. Avrillier S, Tinet E, Ettori D, Tualle JM, Gelebart B. Influence of the emission-reception geometry in laser-induced fluorescence spectra from turbid media. Appl Opt 1998;37(13):2781-2787.
12. Jianan Q, MacAulay C, Lam S, Palcic B. Laser-induced fluorescence spectroscopy at endoscopy: Tissue optics, Monte Carlo modeling, and in vivo measurements. Opt Eng 1995;34:3334-3343.
13. Pfefer TJ, Schomacker KT, Ediger MN, Nishioka NS. Light propagation in tissue during fluorescence spectroscopy with single-fiber probes. IEEE J Quantum Electron 2001;7(6): 1004-1012.
14. Pfefer TJ, Schomacker KT, Ediger MN, Nishioka NS. Multiple-fiber probe design for fluorescence spectroscopy in tissue. Appl Opt 2002;41(22):4712-4721.
15. Pogue BW, Hasan T. Fluorophore quantitation in tissue-simulating media with confocal detection. IEEE J Quantum Electron 1996;2(4):959-964.
16. Zhu C, Liu Q, Ramanujam N. Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: A Monte Carlo simulation. J Biomed Opt 2003;8(2):237-247.
17. Palmer GM, Marshek CL, Vrotsos KM, Ramanujam N. Optimal methods for fluorescence and diffuse reflectance measurements of tissue biopsy samples. Lasers Surg Med 2002;30(3):191-200.
18. van der Breggen EW, Rem A, Christian M, Yang C, Calhoun K, Sterenborg H, Motamedi M. Spectroscopic detection of oral and skin tissue transformation in a model for squamous cell carcinoma: Autofluorescence versus systemic aminolevulinic acid-induced fluorescence. IEEE J Quantum Electron 1996; QE2(4):997-1007.
19. Andrejevic S, Savary JF, Fontolliet C, Monnier P, van Den Bergh H. 7,12-dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: Evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract. Int J Exp Pathol 1996;77(1): 7-14.
20. Balasubramanian S, Elangovan V, Govindasamy S. Fluorescence spectroscopic identification of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Carcinogenesis 1995;16(10):2461-2465.
21. Chen CT, Chiang HK, Chow SN, Wang CY, Lee YS, Tsai JC, Chiang CP. Autofluorescence in normal and malignant human oral tissues and in DMBA-induced hamster buccal pouch carcinogenesis. J Oral Pathol Med 1998;27(10):470-474.
22. Coghlan L, Utzinger U, Drezek R, Heintzelman D, Zuluaga A, Brookner C, Richards-Kortum R, Gimenez-Conti I, Follen M. Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: Results from an animal model. Opt Exp 2000;7(12):436-446.
23. Coghlan L, Utzinger U, Richards-Kortum R, Brookner C, Zuluaga A, Gimenez-Conti I, Follen M. Fluorescence spectroscopy of epithelial tissue throughout the dysplasia-carcinoma sequence in an animal model: Spectroscopic changes precede morphologic changes. Lasers Surg Med 2001;29(1):1-10.
24. Dhingra JK, Zhang X, McMillan K, Kabani S, Manoharan R, Itzkan I, Feld MS, Shapshay SM. Diagnosis of head and neck precancerous lesions in an animal model using fluorescence spectroscopy. Laryngoscope 1998;108(4 Pt 1):471-475.
25. Kluftinger AM, Davis NL, Quenville NF, Lam S, Hung J, Palcic B. Detection of squamous cell cancer and precancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model. Surg Oncol 1992;1(2):183-188.
26. Dillon WR, Goldstein M. Multivariate analysis: Methods and applications. New York: Wiley 1984.
27. Devore J. Probability and statistics for engineering and the sciences. Pacific Grove: Duxbury 2000.
28. Burges C. A tutorial on support vector machines for pattern recognition. Data mining and knowledge discovery 1998;2:121-167.
29. Gunn S. Support vector machines for classification and regression. Southampton: University of Southampton 1998.
30. Thorsten J. SVM light support vector machine version 5.00. 5.00. Dortmund: University of Dortmund 2002.
31. Liu Q, Zhu C, Ramanujam N. Experimental validation of Monte Carlo modeling of fluorescence in tissues in the UV-visible spectrum. J Biomed Opt 2003;8(2):223-236.
32. Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M, Richards-Kortum R. Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications. J Biomed Opt 2001;6(4):385-396.
33. White FH, Gohari K, Smith CJ. Histological and ultrastructural morphology of 7,12 dimethylbenz (alpha)-anthracene carcinogenesis in hamster cheek pouch epithelium. Diagn Histopathol 1981;4(4):307-333.
34. Lin S, Wang L, Jacques SL, Tittel FK. Measurement of tissue optical properties by the use of oblique-incidence optical fiber reflectometry. Appl Opt 1997;36(1):136-143.
35. Marquez G, Wang LV. White light oblique incidence reflectometer for measuring absorption and reduced scattering spectra of tissue-like turbid media. Opt Exp 1997;1(13): 454-460.
36. Liu Q, Ramanujam N. Relationship between depth of a target in a turbid medium and fluorescence measured by a variable-aperture method. Opt Lett 2002;27:104-106.
37. Hull EL, Nichols MG, Foster TH. Localization of luminescent inhomogeneities in turbid media with spatially resolved measurements of cw diffuse luminescence emittance. Appl Opt 1998;37(13):2755-2765.
38. Hyde DE, Farrell TJ, Patterson MS, Wilson BC. A diffusion theory model of spatially resolved fluorescence from depth-dependent fluorophore concentrations. Phys Med Biol 2001;46(2):369-383.